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Australian Laureate Fellowships - Grant ID: FL110100196
Funder
Australian Research Council
Funding Amount
$2,638,208.00
Summary
New dimensions in organic bionics. The advent of the next generation of medical bionic devices is critically dependent on advances in multifunctional organic materials that, like living systems, provide spatial and temporal control. These advances will provide a platform to revolutionise medical treatments such as nerve and muscle regeneration, with impact on neural prosthetics.
Australian Laureate Fellowships - Grant ID: FL180100072
Funder
Australian Research Council
Funding Amount
$3,460,832.00
Summary
Causes and consequence of human trait variation. This project aims to exploit the availability of Big Data from the genomics revolution to understand the relationship between the genome, the environment and complex human traits. New statistical methods and user-friendly software tools will be developed and applied to datasets on millions of individuals to generate new knowledge on human life history variation and healthy ageing. This project will position Australia to benefit from rapid advances ....Causes and consequence of human trait variation. This project aims to exploit the availability of Big Data from the genomics revolution to understand the relationship between the genome, the environment and complex human traits. New statistical methods and user-friendly software tools will be developed and applied to datasets on millions of individuals to generate new knowledge on human life history variation and healthy ageing. This project will position Australia to benefit from rapid advances in genomic technologies, to build and sustain critical capacity in statistical genetics, and better understand the causes and consequence of individual differences in human traits from genetic and environmental factors across the entire human lifespan.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL200100096
Funder
Australian Research Council
Funding Amount
$3,367,940.00
Summary
Mapping the genetic and lifestyle landscape of Healthy Ageing. This project aims to dissect how genes interact with the environment to control healthy ageing using a multidisciplinary approach combining state-of-the-art omics technologies, metabolic and ageing phenotyping and genetic analysis and a highly diverse model system. The project is expected to establish fundamental new understanding of the ageing process by identifying genes that regulate ageing either alone or in response to diet; by ....Mapping the genetic and lifestyle landscape of Healthy Ageing. This project aims to dissect how genes interact with the environment to control healthy ageing using a multidisciplinary approach combining state-of-the-art omics technologies, metabolic and ageing phenotyping and genetic analysis and a highly diverse model system. The project is expected to establish fundamental new understanding of the ageing process by identifying genes that regulate ageing either alone or in response to diet; by defining the mechanism by which such genes control ageing and by identifying biomarkers that predict different ageing outcomes. This knowledge will contribute to future strategies based on genetic testing and biomarkers to optimise healthy ageing in humans. Read moreRead less
Australian Laureate Fellowships - Grant ID: FL220100185
Funder
Australian Research Council
Funding Amount
$3,269,608.00
Summary
Nanostructured Silicon-Based Wearable and Implantable Biosensors. The aim is to gain a deep understanding of the interface between nanostructured-silicon-based nanomaterials and biological systems, to develop a new generation of biosensor technologies applied on and in the body. Using innovative nanofabrication techniques, the team will integrate porous silicon nanomaterials with highly controllable optical and electrochemical properties into wearable and implantable biosensors for detecting bio ....Nanostructured Silicon-Based Wearable and Implantable Biosensors. The aim is to gain a deep understanding of the interface between nanostructured-silicon-based nanomaterials and biological systems, to develop a new generation of biosensor technologies applied on and in the body. Using innovative nanofabrication techniques, the team will integrate porous silicon nanomaterials with highly controllable optical and electrochemical properties into wearable and implantable biosensors for detecting bioanalytes directly and continuously in interstitial fluid, sweat, and blood; critically, they will be capable of long-term monitoring. The outcomes are expected to enable development of downstream applications across medical diagnostics, sports sciences, workplace testing as well as defence and space technologies.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL160100139
Funder
Australian Research Council
Funding Amount
$2,965,538.00
Summary
Outside-In: Strain stiffening as a key to cell control. Outside-In: Strain stiffening as a key to cell control. This research project aims to unravel the highly complex mechanical behaviour of the extracellular matrix, and develop a whole new class of sophisticated and responsive extracellular matrix (ECM) materials. In any multicellular organism, the ECM provides cells with essential mechanical (such as strain stiffening) and biochemical support. The ECM is also critical for biological processe ....Outside-In: Strain stiffening as a key to cell control. Outside-In: Strain stiffening as a key to cell control. This research project aims to unravel the highly complex mechanical behaviour of the extracellular matrix, and develop a whole new class of sophisticated and responsive extracellular matrix (ECM) materials. In any multicellular organism, the ECM provides cells with essential mechanical (such as strain stiffening) and biochemical support. The ECM is also critical for biological processes inside the cell, including proliferation, differentiation and migration. Exactly how the physical and chemical properties of ECMs on the outside of the cell modify the behaviour of a cell on the inside remains unclear. Outcomes would include a blueprint for synthetic ECMs, pushing the boundaries of materials development in the biological and life sciences.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL0992334
Funder
Australian Research Council
Funding Amount
$2,321,000.00
Summary
An Empirical Model of Aboriginal Mental Health. The poor health, academic, and mental health functioning of Aboriginal children is one of Australia's major public health problems. This project will identify the specific factors that lead to these problems and provide an evidence base to shape future empirically-informed interventions to reduce violence and mental health problems in Aboriginal communities. This project directly addresses the National Research Priority of Strengthening Australia ....An Empirical Model of Aboriginal Mental Health. The poor health, academic, and mental health functioning of Aboriginal children is one of Australia's major public health problems. This project will identify the specific factors that lead to these problems and provide an evidence base to shape future empirically-informed interventions to reduce violence and mental health problems in Aboriginal communities. This project directly addresses the National Research Priority of Strengthening Australia's Social and Economic Fabric and a Healthy Start to Life by establishing the empirical platform to shape future policies for enhancing the mental health of Aboriginal youth.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL170100160
Funder
Australian Research Council
Funding Amount
$2,568,846.00
Summary
A philosophy of medicine for the 21st century. This project aims to develop a new theory of health and disease to accommodate developments in contemporary biology such as the ‘developmental origins of health and disease’, the role of the microbiome in physiology, and the fact that our bodies are sites of evolutionary conflict between multiple genomes, particularly in early life. Present science does not fit with common-sense ideas about the identity and the goals of living systems and the projec ....A philosophy of medicine for the 21st century. This project aims to develop a new theory of health and disease to accommodate developments in contemporary biology such as the ‘developmental origins of health and disease’, the role of the microbiome in physiology, and the fact that our bodies are sites of evolutionary conflict between multiple genomes, particularly in early life. Present science does not fit with common-sense ideas about the identity and the goals of living systems and the project expects to generate a close collaboration between philosophers and biomedical scientists so that new ideas about health and disease can be fed back into proof-of-principle projects for innovative new approaches to the study of health and disease. The project will conduct methodologically innovative research in the philosophy of medicine, working in close collaboration with biomedical scientists to confront the transformational discoveries about the nature of living systems that have been made in the first years of the current century and to actively shape new forms of enquiry into health that reflect those discoveries. It will make the discipline of philosophy an active participant in the creation of integrative biomedical research.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL0992138
Funder
Australian Research Council
Funding Amount
$3,100,000.00
Summary
Towards antibacterials without resistance. Innovative automation technologies will be used to create and investigate a revolutionary new approach to disable pathogenic superbugs, bacteria resistant to multiple antibiotics. The chemicals created and proteins evaluated in this research program will advance fundamental knowledge about the molecular weapons that bacteria produce to cause disease; deliver social and economic benefits to Australia through the development of potential new antibacterial ....Towards antibacterials without resistance. Innovative automation technologies will be used to create and investigate a revolutionary new approach to disable pathogenic superbugs, bacteria resistant to multiple antibiotics. The chemicals created and proteins evaluated in this research program will advance fundamental knowledge about the molecular weapons that bacteria produce to cause disease; deliver social and economic benefits to Australia through the development of potential new antibacterial treatments; contribute to Australia's continued international leading role in drug discovery research; enhance international links and attract industry investment in Australia; and provide a stimulating research training environment to inspire and motivate the next generation of scientists.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL0992247
Funder
Australian Research Council
Funding Amount
$2,988,295.00
Summary
Advances at the frontiers of subatomic physics and cross-disciplinary applications of the associated techniques. The candidate is an international scientific leader, in terms of his own research, his responsibilities within the United States Department of Energy (DoE) and his role as Chair of the International Union of Pure and Applied Physics (IUPAP) Working Group on International Cooperation in Nuclear Physics. His return to South Australia to establish a major new research centre in the physi ....Advances at the frontiers of subatomic physics and cross-disciplinary applications of the associated techniques. The candidate is an international scientific leader, in terms of his own research, his responsibilities within the United States Department of Energy (DoE) and his role as Chair of the International Union of Pure and Applied Physics (IUPAP) Working Group on International Cooperation in Nuclear Physics. His return to South Australia to establish a major new research centre in the physical sciences will dramatically enhance the State's reputation in science and engineering, an essential component of its contribution to the nation's defence. It will underline Australia's commitment to contribute its share to advancing fundamental science. The involvement of senior researchers from fields as diverse as applied optics and mathematical biology will ensure that the opportunities for cross-disciplinary research are fully exploited.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL170100167
Funder
Australian Research Council
Funding Amount
$2,295,215.00
Summary
Differentiating the cognitive basis of unproductive versus productive worry. This project aims to delineate the individual differences in cognitive functioning that distinguish between the tendency to experience unproductive versus productive worry. For some people, worry severely compromises well-being, while for others worry yields significant benefits by fostering preparatory behaviours that protect against misfortune. Using innovative and compelling hypotheses, as well as laboratory and fiel ....Differentiating the cognitive basis of unproductive versus productive worry. This project aims to delineate the individual differences in cognitive functioning that distinguish between the tendency to experience unproductive versus productive worry. For some people, worry severely compromises well-being, while for others worry yields significant benefits by fostering preparatory behaviours that protect against misfortune. Using innovative and compelling hypotheses, as well as laboratory and fieldwork approaches, this project will deliver the capacity to assess, predict, and explain the individual differences in unproductive and productive worrying that underpin variability in resilient responding to situations in which adaptive action can mitigate real-world risk. This project will have major scientific impact, generating influential publications concerning the cognitive distinctions between productive and unproductive worry that will position Australia as a global leader in this field.Read moreRead less