The Australian Research Data Commons (ARDC) invites you to participate in a short survey about your
interaction with the ARDC and use of our national research infrastructure and services. The survey will take
approximately 5 minutes and is anonymous. It’s open to anyone who uses our digital research infrastructure
services including Reasearch Link Australia.
We will use the information you provide to improve the national research infrastructure and services we
deliver and to report on user satisfaction to the Australian Government’s National Collaborative Research
Infrastructure Strategy (NCRIS) program.
Please take a few minutes to provide your input. The survey closes COB Friday 29 May 2026.
Complete the 5 min survey now by clicking on the link below.
From causative genes to establishing therapies for patients with neuromuscular diseases. A major focus of this project will be pursuing multiple therapeutic approaches for a class of skeletal muscle diseases, which are most often severe and lethal within the first year of life. It will also hunt down the defective genes in human patients with other neuromuscular diseases and explore how these cause disease.
Accessing the therapeutic potential of carbon monoxide. Despite carbon monoxide being regarded as the ”silent killer”, it is now established that this molecule has beneficial effects for a number of conditions and pathologies, including inflammation, organ transplant rejection, bacterial infection, acute liver failure and as an aid in cancer therapies. This project proposes to explore the photochemistry of rhenium-containing species to discover more efficient carbon monoxide delivery agents. By ....Accessing the therapeutic potential of carbon monoxide. Despite carbon monoxide being regarded as the ”silent killer”, it is now established that this molecule has beneficial effects for a number of conditions and pathologies, including inflammation, organ transplant rejection, bacterial infection, acute liver failure and as an aid in cancer therapies. This project proposes to explore the photochemistry of rhenium-containing species to discover more efficient carbon monoxide delivery agents. By combining synthetic chemistry, photochemistry and cellular biology it is anticipated that this multidisciplinary research programme will advance the area of carbon monoxide therapies by preparing safer agents for the targeted and controlled delivery of carbon monoxide.Read moreRead less
Genetic networks controlling lymphocyte differentiation. White blood cells are produced in the bone marrow from a rare stem cell. This research aims to understand how a handful of master-regulator genes act in the stem cells to produce the white blood cells that are required for our immune response to microbes, vaccination and to prevent cancer.
Immuno-epidemiological insights into the development of immunity to malaria and drug resistance. This project aims to better understand the maintenance and acquisition of immunity to malaria in high risk groups. It will also attempt to elucidate how immunity can interfere with the therapeutic efficacy of antimalarials, especially in the assessment of emerging drug resistance. The over-riding hypothesis is that differences in malaria transmission will lead to differential acquisition of immunity ....Immuno-epidemiological insights into the development of immunity to malaria and drug resistance. This project aims to better understand the maintenance and acquisition of immunity to malaria in high risk groups. It will also attempt to elucidate how immunity can interfere with the therapeutic efficacy of antimalarials, especially in the assessment of emerging drug resistance. The over-riding hypothesis is that differences in malaria transmission will lead to differential acquisition of immunity and efficacy of malaria interventions within and between populations. Understanding immunity to malaria is pivotal to develop new interventions, to understand the effectiveness of current malaria treatment and control programs to reduce the global burden of malarial disease.Read moreRead less
Mechanisms of human immunodeficiency virus entry into cells. This project will develop an understanding of how human immunodeficiency virus (HIV) evolves in people to become better able to infect, and hence destroy, cells of the immune system. It is expected that new knowledge into how HIV alters the way it interacts with these cells will reveal insights for the design of vaccines, drugs and new diagnostic tests.
DNA end resection: from basic mechanisms to genome editing. The project aims to understand processes underlying genome editing, a bioengineering process that introduces specific mutations into genomic DNA. Homologous recombination and nonhomologous end-joining pathways play a crucial role in repairing broken DNA strands, which are a toxic form of DNA damage. The proteins that function in the repair process have been recently identified, but it remains unclear how they function on a mechanistic l ....DNA end resection: from basic mechanisms to genome editing. The project aims to understand processes underlying genome editing, a bioengineering process that introduces specific mutations into genomic DNA. Homologous recombination and nonhomologous end-joining pathways play a crucial role in repairing broken DNA strands, which are a toxic form of DNA damage. The proteins that function in the repair process have been recently identified, but it remains unclear how they function on a mechanistic level and how either of the two main pathways is selected. The project aims to define how the activity of a key control protein, Sae2 (Sporulation in the Absence of Spo Eleven), is regulated by posttranslational modifications, and how this activates homologous recombination. The project plans to first use Saccharomyces cerevisiae yeast as a model and then to extend research into the human system in an attempt to improve the efficiency of genome editing. Read moreRead less
Lipidomics of vision. Presbyopia and cataract are the major causes of visual impairment worldwide. Nevertheless, our understanding of lens ageing at both a cellular and molecular level is limited. This project will gain new insight into the effect of age on lens membrane lipids and their role in the development of presbyopia and cataract.
The Protein Corona: Imaging the nanoparticle biological identity card. The project will determine how the intrinsic physico-chemical properties of nanoparticles translate into extrinsic biological properties through their interaction with physiological proteins in the body. This process is complex and poorly understood due to our inability to visualise it through standard imaging techniques. The project aims to develop a new tool to visualise, study, quantify and design the protein ‘corona’. The ....The Protein Corona: Imaging the nanoparticle biological identity card. The project will determine how the intrinsic physico-chemical properties of nanoparticles translate into extrinsic biological properties through their interaction with physiological proteins in the body. This process is complex and poorly understood due to our inability to visualise it through standard imaging techniques. The project aims to develop a new tool to visualise, study, quantify and design the protein ‘corona’. These are the adsorbed protein layers that are rapidly formed in contact with biological liquids which allow cells to recognise and process nanoparticles. The proteins are dependent on factors such as size, shape, surface chemistry and biological history of the particles. Being able to ‘read’ and ‘write’ the protein corona would enable efficient cellular targeting of pharmaceutical drugs.Read moreRead less
Molecular characterisation of hypervirulence and the infectious cycle in Clostridium difficile. Gut diseases caused by the bacterium Clostridium difficile are a significant animal and public health problem in Australia and many other countries. This project will allow us to understand how this bacterium causes disease, leading to the development of much needed preventative and treatment strategies for animals and human patients.
Extending X-ray Crystallography to Allow Structure Retrieval from Highly Disordered Crystals and Nanocrystals. X-ray crystallography is one of the most important tools in structural biology, responsible for over 80 per cent of the protein structures solved today. Obtaining X-ray diffraction data however is critically dependent on having large, high quality crystals. Many proteins, particularly membrane proteins, only form nanocrystals or crystals of poor quality which prevents their structure be ....Extending X-ray Crystallography to Allow Structure Retrieval from Highly Disordered Crystals and Nanocrystals. X-ray crystallography is one of the most important tools in structural biology, responsible for over 80 per cent of the protein structures solved today. Obtaining X-ray diffraction data however is critically dependent on having large, high quality crystals. Many proteins, particularly membrane proteins, only form nanocrystals or crystals of poor quality which prevents their structure being solved. This project aims to combine ideas from X-ray coherent diffraction imaging and X-ray crystallography to develop a method that can be used for structure retrieval from nanocrystals or crystals which are highly disordered. A particular emphasis will be placed on solving the structure of membrane proteins which are of special importance in drug development.Read moreRead less