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Spatio-temporal activation of genes in cells and mice. This project aims to develop novel genetic methods and instrumentation for the local, rapid and reversible activation of genes in cells and mice. This project expects to generate highly innovative light- and sound-based technologies that will permit to study living systems on the gene-level with unprecedented precision. Expected outcomes include new research and technology capacity to broadly address fundamental biological questions and to c ....Spatio-temporal activation of genes in cells and mice. This project aims to develop novel genetic methods and instrumentation for the local, rapid and reversible activation of genes in cells and mice. This project expects to generate highly innovative light- and sound-based technologies that will permit to study living systems on the gene-level with unprecedented precision. Expected outcomes include new research and technology capacity to broadly address fundamental biological questions and to create new applied processes. This project intends to provide significant benefits, such as enhanced knowledge generation, multidisciplinary training opportunities and patentable technologies.Read moreRead less
The mechanochemical basis of cell polarity. This project aims to study how epithelial cells initiate polarisation, a major question in biology that conventional biochemical, cell biological and genetic approaches have not answered. This project will investigate the mechanochemical basis of symmetry breaking in the cellular cortex, a thin layer of actomyosin filaments underneath the plasma membrane, and how this forms signalling zones. Understanding polarity is expected to improve epithelia manip ....The mechanochemical basis of cell polarity. This project aims to study how epithelial cells initiate polarisation, a major question in biology that conventional biochemical, cell biological and genetic approaches have not answered. This project will investigate the mechanochemical basis of symmetry breaking in the cellular cortex, a thin layer of actomyosin filaments underneath the plasma membrane, and how this forms signalling zones. Understanding polarity is expected to improve epithelia manipulation in disciplines from tissue engineering to regenerative biology and reveal how epithelial architecture and physiology are generated.Read moreRead less
Hidden complexity in microRNA function. This project aims to determine the extent to which microRNAs function through “non-canonical” mechanisms within cell nuclei, how their roles are expanded by naturally occurring sequence variation and how their activity is controlled by little known families of genes that sequester and inhibit their availability. The knowledge generated is significant as microRNAs regulate the expression of virtually all genes and biological processes, yet these mechanisms ....Hidden complexity in microRNA function. This project aims to determine the extent to which microRNAs function through “non-canonical” mechanisms within cell nuclei, how their roles are expanded by naturally occurring sequence variation and how their activity is controlled by little known families of genes that sequester and inhibit their availability. The knowledge generated is significant as microRNAs regulate the expression of virtually all genes and biological processes, yet these mechanisms of function remain poorly characterised and seldom considered. The expected outcome of better understanding mechanisms through which microRNAs work should provide significant benefit to safe and effective development of microRNAs for future agricultural or therapeutic application.Read moreRead less
Systems modelling for synergistic ecological-climate dynamics. The project aims to improve forecasts of the response of biodiversity to future climate change and so improve on-ground conservation management. A systems modelling framework will be developed and tested against real-world data to integrate a wide variety of biological and geophysical inputs and so produce more realistic predictions.
Integrating models with molecular 'logbooks' to better forecast extinction risk from climate change. Current forecasts indicate that human-driven climate change will likely cause widespread biodiversity loss. However, climatic shifts during the Quaternary (2.6 million years ago to present), similar in magnitude to those projected for the 21st century, did not apparently cause extensive extinctions (with the exception of the megafauna). This project aims to use models linked to past responses imp ....Integrating models with molecular 'logbooks' to better forecast extinction risk from climate change. Current forecasts indicate that human-driven climate change will likely cause widespread biodiversity loss. However, climatic shifts during the Quaternary (2.6 million years ago to present), similar in magnitude to those projected for the 21st century, did not apparently cause extensive extinctions (with the exception of the megafauna). This project aims to use models linked to past responses imprinted in species’ genes to resolve whether the disparity between observed and predicted extinction rates comes from models over-predicting species loss due to climate change. It will use this genetic-demographic approach to improve predictions of biodiversity responses to global change by establishing the biological and environmental determinants of extinction.Read moreRead less
The evolution of species traits and spread during biological invasions. Exotic species pose a dire threat to Australia's biodiversity and natural resources due to the speed at which non-indigenous pests spread and the ecological and environmental damage they are capable of causing. The proposed research, on identifying traits associated with the spread of exotic vertebrate species and modelling the reproductive and dispersal parameters among different populations, will provide new knowledge and ....The evolution of species traits and spread during biological invasions. Exotic species pose a dire threat to Australia's biodiversity and natural resources due to the speed at which non-indigenous pests spread and the ecological and environmental damage they are capable of causing. The proposed research, on identifying traits associated with the spread of exotic vertebrate species and modelling the reproductive and dispersal parameters among different populations, will provide new knowledge and aid in developing innovative solutions for arresting the spread of exotic species. The validation of current models of spread will represent a major and timely addition to the national research capability on exotic species, and add substantially to Australia's reputation as a global leader in evolutionary ecology.Read moreRead less
Ageing and the muscle stem cell niche. Adult stem cells are critical for repair and maintenance of tissues and ageing tissues show reduced stem cell function. This project will focus on how ageing leads to disruption of communication between muscle stem cells and their niche. The project aims to identify new therapeutic targets for age-related muscle wasting and reduced mobility in the elderly.
Discovering the pathways and mechanisms underlying bio-insecticide control of the global migratory pest, diamondback moth, Plutella xylostella. Sustaining crop yield and maintaining food security is a significant worldwide concern. This project aims to strengthen insect pest control strategies and improve bio-insecticide use in agriculture through better understanding of the mode of action of Bacillus thuringiensis (Bt) insecticides. It aims to improve their efficacy and evaluate opportunities t ....Discovering the pathways and mechanisms underlying bio-insecticide control of the global migratory pest, diamondback moth, Plutella xylostella. Sustaining crop yield and maintaining food security is a significant worldwide concern. This project aims to strengthen insect pest control strategies and improve bio-insecticide use in agriculture through better understanding of the mode of action of Bacillus thuringiensis (Bt) insecticides. It aims to improve their efficacy and evaluate opportunities to develop bio-insecticides based on plant saponins. This will assist in determining the risk of insecticide resistant moths migrating to Australia, and within our borders. This project aims to provide opportunities to improve transgenic Bt-crops and Bt-sprays, provide commercial development of new bio-insecticides, and develop optimal control strategies for major Australian migratory pests.Read moreRead less
DNA and the missing: ancient DNA and advanced forensic identification. Identifying the remains of missing persons, disaster victims and war dead is of major social and cultural importance and has significant implications for national and international justice systems. This project will apply expertise in analysis of ancient DNA to build capacity and expertise within Australia to identify highly degraded human remains.
The Quest for Ultimate Measurement Precision. Precision measurement is the foundation upon which modern technological society is built. The highest quality measurement devices rely on stable clocks for their operation. The group's existing research has been aimed at developing some of the world's most precise measurement tools based on clocks and lasers. In parallel with this, other scientists have developed the means for exquisite control of light on the microscopic scale. By combining these tw ....The Quest for Ultimate Measurement Precision. Precision measurement is the foundation upon which modern technological society is built. The highest quality measurement devices rely on stable clocks for their operation. The group's existing research has been aimed at developing some of the world's most precise measurement tools based on clocks and lasers. In parallel with this, other scientists have developed the means for exquisite control of light on the microscopic scale. By combining these two technologies, both of which lie at the extreme limit of precision, the group will develop a new generation of technology for fundamental science objectives as well as for industrial needs.Read moreRead less