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Gating, specificity and regulation of the YggB channel protein from Corynebacterium glutamicum. The proposed research will greatly contribute to our understanding of the functioning of a bacterial membrane channel/transporter, which has played a significant role in biotechnology of commercially important amino acids. A direct national benefit will result from establishing collaboration with a leading German laboratory providing expertise in protein biochemistry and molecular microbiology not ava ....Gating, specificity and regulation of the YggB channel protein from Corynebacterium glutamicum. The proposed research will greatly contribute to our understanding of the functioning of a bacterial membrane channel/transporter, which has played a significant role in biotechnology of commercially important amino acids. A direct national benefit will result from establishing collaboration with a leading German laboratory providing expertise in protein biochemistry and molecular microbiology not available in Australia. The acquired knowledge will present an original contribution which will have a strong impact on a very competitive field of molecular microbiology and biotechnology.Read moreRead less
The role of mechanosensitive (MS) ion channels in magnetoreception. The magnetic field of the Earth has for long been known to influence the behaviour and orientation of a variety of organisms. Experimental study of the magnetic sense has however, been impaired by the lack of a plausible cellular and/or molecular mechanism providing meaningful explanation for detection of magnetic fields by living organisms. Recently, mechanosensitive (MS) ion channels have been implied to play a role in magneto ....The role of mechanosensitive (MS) ion channels in magnetoreception. The magnetic field of the Earth has for long been known to influence the behaviour and orientation of a variety of organisms. Experimental study of the magnetic sense has however, been impaired by the lack of a plausible cellular and/or molecular mechanism providing meaningful explanation for detection of magnetic fields by living organisms. Recently, mechanosensitive (MS) ion channels have been implied to play a role in magnetoreception. Based on our preliminary investigations, which suggest that the activity of bacterial MS channels may be affected by magnetic fields, we propose to study effects of magnetic fields on MS ion channels in Gram-negative bacteria Escherichia coli and Magnetospirillum magnetotacticum. The project promises also to contribute towards better understanding of adverse effects of electromagnetic radiation on human health and towards understanding the mechanisms behind remote magnetic-nanoparticle mediated activation of MS ion channels.Read moreRead less
DNA Dynamics is Shear and Extensional Flows: Simulation and Single Molecule Experiments. The proposal seeks to establish a collaboration between Monash University and Stanford University in order to combine several recent experimental and theoretical advances that have been made by the individual groups in single molecule experimental techniques, extensional rheometry, and molecular rheology, to obtain new insights into the structure and dynamics of biopolymers. The central aim is to make a sign ....DNA Dynamics is Shear and Extensional Flows: Simulation and Single Molecule Experiments. The proposal seeks to establish a collaboration between Monash University and Stanford University in order to combine several recent experimental and theoretical advances that have been made by the individual groups in single molecule experimental techniques, extensional rheometry, and molecular rheology, to obtain new insights into the structure and dynamics of biopolymers. The central aim is to make a significant contribution towards bringing state-of-the-art techniques used for the characterization of polymeric systems to bear on the nature and origin of the elastic properties of biopolymers.Read moreRead less
The flow properties of proteins and other biopolymers. The living cell is an extraordinary organization with a vast variety of biomacromolecules carrying out myriads of functions with great specificity and accuracy. The key issue in cell biology is to unravel the structures of biopolymers and the deep connection that exists between structure and function. This interdisciplinary research program combines recent advances in experimental and theoretical rheology, with advances in protein science, t ....The flow properties of proteins and other biopolymers. The living cell is an extraordinary organization with a vast variety of biomacromolecules carrying out myriads of functions with great specificity and accuracy. The key issue in cell biology is to unravel the structures of biopolymers and the deep connection that exists between structure and function. This interdisciplinary research program combines recent advances in experimental and theoretical rheology, with advances in protein science, to investigate the response of biopolymers to deformation. This approach will lead to insights into the problem of protein folding, the interaction of biopolymers with surfaces, and the physical basis for the mechanical properties of biopolymers.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561013
Funder
Australian Research Council
Funding Amount
$220,000.00
Summary
X-ray diffraction System for Protein Crystallography and Structural Biology. Knowledge of protein structures enables researchers to explain cellular function at a molecular level. In particular, it provides essential information to understand the mechanism of diseases, such as cancer or AIDS, and it ultimately leads to the design of better drugs.
An in-house X-ray protein crystallography facility will allow us to determine the structures of key proteins effectively and competitively, opening up ....X-ray diffraction System for Protein Crystallography and Structural Biology. Knowledge of protein structures enables researchers to explain cellular function at a molecular level. In particular, it provides essential information to understand the mechanism of diseases, such as cancer or AIDS, and it ultimately leads to the design of better drugs.
An in-house X-ray protein crystallography facility will allow us to determine the structures of key proteins effectively and competitively, opening up extensive possibilities for multi-disciplinary ground-breaking research.
The University research portfolio has evolved to embrace the revolution in structural biology with numerous projects and collaborations focusing on proteins involved in bacterial infections, degenerative disorders and biotechnological applications.Read moreRead less
Catalytic Electron Transfer in Photosystem II of Plants and Bacteria. Large scale hydrogen production from electricity and abundant water sources, such as sea water, represents the ultimate goal for the research described here. This is part of an overall scheme, called "Artificial Photosynthesis", to generate clean renewable energy. Although the present project is but one step in this ambitious program, it directly addresses a key hurdle which must be overcome to make the project feasible. This ....Catalytic Electron Transfer in Photosystem II of Plants and Bacteria. Large scale hydrogen production from electricity and abundant water sources, such as sea water, represents the ultimate goal for the research described here. This is part of an overall scheme, called "Artificial Photosynthesis", to generate clean renewable energy. Although the present project is but one step in this ambitious program, it directly addresses a key hurdle which must be overcome to make the project feasible. This is the efficient electrical conversion of water into hydrogen and oxygen, a two part process of which the latter is the most chemically difficult. The project aims to 'steal nature's secrets', by deciphering and then technologically mimicking the highly efficient means by which plants carry out these processes.Read moreRead less
Deciphering the tectonic history of the Musgrave Block to assist mineral explorers and regional synthesis programs. Effective mineral exploration strategies in complex basement terrains are increasingly reliant on integrated, data-rich, tectonic models. In this project we will focus a large multidisciplinary team to develop a tectonic model for the evolution of the Musgrave Block in central Australia. This large, poorly understood terrain occupies a critical structural location, separating the ....Deciphering the tectonic history of the Musgrave Block to assist mineral explorers and regional synthesis programs. Effective mineral exploration strategies in complex basement terrains are increasingly reliant on integrated, data-rich, tectonic models. In this project we will focus a large multidisciplinary team to develop a tectonic model for the evolution of the Musgrave Block in central Australia. This large, poorly understood terrain occupies a critical structural location, separating the northern and southern Australian cratons. By constraining models of crustal evolution and architecture, the project will underpin future mineral exploration programs in this highly prospective greenfields region and define the role of the Musgrave Block in the assembly of Proterozoic Australia.Read moreRead less
Developing a Tectonic Framework for the Gawler Craton: Paving the Way for Successful Mineral Exploration Programs. The late Archaean to Mesoproterozoic Gawler Craton is the major Precambrian province in southern Australia. However, despite containing one of the largest orebodies on Earth, exploration expenditure in the craton has been comparatively low, and hampered by insufficient knowledge of the craton's tectonic systems. This project uses an integrated package of geochemical, isotopic and ....Developing a Tectonic Framework for the Gawler Craton: Paving the Way for Successful Mineral Exploration Programs. The late Archaean to Mesoproterozoic Gawler Craton is the major Precambrian province in southern Australia. However, despite containing one of the largest orebodies on Earth, exploration expenditure in the craton has been comparatively low, and hampered by insufficient knowledge of the craton's tectonic systems. This project uses an integrated package of geochemical, isotopic and geophysical tools to develop a comprehensive model for the tectonic evolution of the Gawler Craton. The project will constrain the development of the Gawler Craton in the context of Precambrian Australian evolution, and offer insights into universal processes of lithosphere formation, growth and stabilisation.Read moreRead less
Tectonic links between the Musgrave Province and the North Australian Craton: correlations, event chronology, and tectonothermal regimes. Developing effective mineral exploration strategies relies on data-rich tectonic models that seek to explain the full history of a terrain. In the Australian context the tectonic evolution of the Musgrave Province is a key focus of the minerals industry due to its widely recognised potential for base-metal mineralisation. This project will develop tectonic mod ....Tectonic links between the Musgrave Province and the North Australian Craton: correlations, event chronology, and tectonothermal regimes. Developing effective mineral exploration strategies relies on data-rich tectonic models that seek to explain the full history of a terrain. In the Australian context the tectonic evolution of the Musgrave Province is a key focus of the minerals industry due to its widely recognised potential for base-metal mineralisation. This project will develop tectonic models that encompass the evolution of the Musgrave Province and the adjacent North Australia Craton. The outcomes of the project will reduce risk to mineral explorers and make an important contribution to the broader question Australia's Proterozoic evolution.Read moreRead less
Magmatism, Metamorphism and Mineralisation: The Development of an Isotopic and Geochemical Framework for the Curnamona Cu-Au Province. Recent advances have highlighted the potential significance of the Olary Domain in the Curnamona Province in southern Australia as an important Proterozoic copper-gold district. However, an outstanding problem yet to be solved is the interplay between mineralisation, granitic magmatism and the metamorphic history of the Province. This multi-disciplinary project ....Magmatism, Metamorphism and Mineralisation: The Development of an Isotopic and Geochemical Framework for the Curnamona Cu-Au Province. Recent advances have highlighted the potential significance of the Olary Domain in the Curnamona Province in southern Australia as an important Proterozoic copper-gold district. However, an outstanding problem yet to be solved is the interplay between mineralisation, granitic magmatism and the metamorphic history of the Province. This multi-disciplinary project will use isotopic and geochemical tools to develop an integrated geologic framework within which to view mineralisation. The outcomes will enhance the prospectivity of the region and make an important contribution to the globally relevant question of controls on Proterozoic copper-gold systems.Read moreRead less