A modelling challenge: bridging the gap between molecular and neuronal networks. We will develop innovative frameworks, which unify small-scale molecular activity with electrical signals in branches of brain cells. This research aims to enhance our understanding how molecular scale phenomena influence brain disease, via studying the model dynamics using cutting-edge techniques on a supercomputer. The socio-economic benefits to Australia include: (i) Enhancing Australia's international reputation ....A modelling challenge: bridging the gap between molecular and neuronal networks. We will develop innovative frameworks, which unify small-scale molecular activity with electrical signals in branches of brain cells. This research aims to enhance our understanding how molecular scale phenomena influence brain disease, via studying the model dynamics using cutting-edge techniques on a supercomputer. The socio-economic benefits to Australia include: (i) Enhancing Australia's international reputation for cutting-edge multidisciplinary research; (ii) international collaborations will be strengthened; (iii) outcomes will potentially lead to commercialisation opportunities; (iv) results will ultimately lay the foundations to explore the cellular and molecular origin of brain disorders.Read moreRead less
Novel RF Controlled Electromechanical Microvalve. The significance of the proposed microvalve is its potential use in exciting biomedical applications such as in drug delivery and fertility control. For human body implantation, it must be batteryless, wireless and be made of a biofriendly-polymer. We propose to meet all three criteria, based on novel use of surface acoustic waves (SAWs) as the actuation mechanism in a polymer material. Energy for actuation will be supplied by a radio frequency ( ....Novel RF Controlled Electromechanical Microvalve. The significance of the proposed microvalve is its potential use in exciting biomedical applications such as in drug delivery and fertility control. For human body implantation, it must be batteryless, wireless and be made of a biofriendly-polymer. We propose to meet all three criteria, based on novel use of surface acoustic waves (SAWs) as the actuation mechanism in a polymer material. Energy for actuation will be supplied by a radio frequency (RF) signal. We propose to model, design and demonstrate the device in laboratory conditions. This will enable development of application specific designs in future programs, such as ARC linkage.Read moreRead less
Wireless microvalve for biomedical applications. This program will investigate and perform an in-laboratory proof-of-concept demonstration of a polymer microvalve that can operate by a remote control radio signal. This will be a wireless microvalve that does not require a battery power source. This advance in the technology and scientific knowledge will have important applications for humankind ranging from drug delivery devices to through to valves in chips that can perform microfluidic chemica ....Wireless microvalve for biomedical applications. This program will investigate and perform an in-laboratory proof-of-concept demonstration of a polymer microvalve that can operate by a remote control radio signal. This will be a wireless microvalve that does not require a battery power source. This advance in the technology and scientific knowledge will have important applications for humankind ranging from drug delivery devices to through to valves in chips that can perform microfluidic chemical analysis. A far reaching long-range vision is its use in electronically reversible male fertility control. The community benefit in terms of novel biomedical devices and the resulting large international commercial market is significant.Read moreRead less
TeraHertz Cell Cluster Imaging. With this program, Australia will benefit from the interaction between physics, engineering, biology and medicine to develop a new TeraHertz imaging system. The project will identify the factors that contribute to TeraHertz contrast in soft tissue cell cultures, thereby developing a non-invasive imaging system to show contrast between diseased and healthy cells. This is a fundamental step towards a system for diagnosing disease states of skin cells, for example, t ....TeraHertz Cell Cluster Imaging. With this program, Australia will benefit from the interaction between physics, engineering, biology and medicine to develop a new TeraHertz imaging system. The project will identify the factors that contribute to TeraHertz contrast in soft tissue cell cultures, thereby developing a non-invasive imaging system to show contrast between diseased and healthy cells. This is a fundamental step towards a system for diagnosing disease states of skin cells, for example, the early detection of melanoma. Ultimately, Australia will benefit from a new technology, and new diagnostic biomedical techniques, for rapid, non-invasive and reliable skin cancer diagnosis.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347962
Funder
Australian Research Council
Funding Amount
$218,000.00
Summary
Adelaide Mass Spectrometry and Analysis Facility. This joint proposal by two South Australian universities and the Hanson Institute seeks to establish a facility for rapid characterisation and identification of biomolecules by means of MALDI-TOF and Nano LC mass spectrometry. The requested equipment is not available in South Australia. This proposal would establish a Nano LC (Q-TOF) node at the University of Adelaide-University of South Australia location and a MALDI-TOF node at the Flinders loc ....Adelaide Mass Spectrometry and Analysis Facility. This joint proposal by two South Australian universities and the Hanson Institute seeks to establish a facility for rapid characterisation and identification of biomolecules by means of MALDI-TOF and Nano LC mass spectrometry. The requested equipment is not available in South Australia. This proposal would establish a Nano LC (Q-TOF) node at the University of Adelaide-University of South Australia location and a MALDI-TOF node at the Flinders location. Its presence would greatly enhance the quality of research and teaching in priority areas such as proteomics, bioinformatics and nanotechnology and would provide a basis for fostering university and biotechnology industry collaborations.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0239035
Funder
Australian Research Council
Funding Amount
$900,000.00
Summary
Regional facility for surface and micro-structure analysis. Adelaide, Flinders and SA Universities seek to enhance the regional facility for surface and microstructure analysis. Equipment includes electron back scatter pattern imaging, high resolution coater, microprobe (CAMECA SX51) upgrade and X ray microtomography to be located at Adelaide University Centre for Electron Microscopy and Microstructure Analysis, the hub of the regional facility. The University of South Australia Ian Wark Researc ....Regional facility for surface and micro-structure analysis. Adelaide, Flinders and SA Universities seek to enhance the regional facility for surface and microstructure analysis. Equipment includes electron back scatter pattern imaging, high resolution coater, microprobe (CAMECA SX51) upgrade and X ray microtomography to be located at Adelaide University Centre for Electron Microscopy and Microstructure Analysis, the hub of the regional facility. The University of South Australia Ian Wark Research Institute node will house ToF-SIMS and SAM upgrades, the Flinders node a multimode STM atomic force microscope, and the Adelaide University Waite Campus node confocal xyz control and digital camera. Applications include biological, materials and geological research projects.Read moreRead less
The prediction of sleep/wake behaviour based on physiological and social factors. The prevalence of shiftwork has increased in Australia over the last few decades. Shiftworkers obtain less sleep, have greater difficulty maintaining good relationships, have poorer health, and are more likely to be injured at work than others. Using the largest dataset of its kind, we will substantially contribute to understanding the relationships between work hours, sleep, performance and safety. Ultimately, the ....The prediction of sleep/wake behaviour based on physiological and social factors. The prevalence of shiftwork has increased in Australia over the last few decades. Shiftworkers obtain less sleep, have greater difficulty maintaining good relationships, have poorer health, and are more likely to be injured at work than others. Using the largest dataset of its kind, we will substantially contribute to understanding the relationships between work hours, sleep, performance and safety. Ultimately, the project will answer a question critical to workplace safety - how much time off between shifts is needed to be alert and safe at work? The project will also produce tools to help industry design fatigue-friendly rosters, improving the safety, productivity and general well-being of shiftworkers in Australia and overseas.Read moreRead less
Breaking The Wavelength Barrier: Near-Field T-ray Imaging. Australia will benefit from the interaction between engineering, physics, and biology to develop a new T-ray imaging system that will ultimately be able to probe microstructures, biological single cells or even neurons. The project will exploit a powerful new electrooptical technique for obtaining chemical 'fingerprints' at the cellular level. This breakthrough will be a fundamental step towards a system for probing disease states of sin ....Breaking The Wavelength Barrier: Near-Field T-ray Imaging. Australia will benefit from the interaction between engineering, physics, and biology to develop a new T-ray imaging system that will ultimately be able to probe microstructures, biological single cells or even neurons. The project will exploit a powerful new electrooptical technique for obtaining chemical 'fingerprints' at the cellular level. This breakthrough will be a fundamental step towards a system for probing disease states of single cells and will open up new lines of scientific enquiry. Ultimately, Australia will benefit from a new technology and new diagnostic biomedical techniques. This is potentially an enabling technology for future customised medicine, where rapid biochip sensing becomes foreseeable.Read moreRead less
Towards a miniaturised on-chip terahertz biosensing system. Terahertz (or T-ray) radiation is highly sensitive to minute changes in the molecular structure of many substances. Furthermore most packing materials are transparent to this new form of radiation. This implies enormous potential for T-rays in a range of applications from quality control via non-invasive contact-less chemical fingerprinting through to safety and security applications. A detailed study of the molecular vibrations that gi ....Towards a miniaturised on-chip terahertz biosensing system. Terahertz (or T-ray) radiation is highly sensitive to minute changes in the molecular structure of many substances. Furthermore most packing materials are transparent to this new form of radiation. This implies enormous potential for T-rays in a range of applications from quality control via non-invasive contact-less chemical fingerprinting through to safety and security applications. A detailed study of the molecular vibrations that give rise to these fingerprints will help chemists and biologists to learn more about the underlying molecular binding forces, impacting on wide applications for safe non-invasive sensing in the medical, security, chemical and food industries.Read moreRead less
Mathematical and mechanical models in nano-engineering and nanomedicine. The major environmental problems generated from global warming and the major human health problems, like cancer and diabetes, if they are to be solved at all, will most likely be resolved making use of advances in nanobiotechnology. This proposal will position Australia as a leader in the modelling of nanodevices such as gigahertz oscillators, nano-electromagnets, nanosensors, nanosyringes and nanoporous media suitable for ....Mathematical and mechanical models in nano-engineering and nanomedicine. The major environmental problems generated from global warming and the major human health problems, like cancer and diabetes, if they are to be solved at all, will most likely be resolved making use of advances in nanobiotechnology. This proposal will position Australia as a leader in the modelling of nanodevices such as gigahertz oscillators, nano-electromagnets, nanosensors, nanosyringes and nanoporous media suitable for hydrogen storage and gas separation, which will lead to new technologies and commercial spin-offs that will be of major benefit to this country. The applicants will develop a range of topics in nano-engineering and nanomedicine, training a team that will provide the next generation of researchers in these vital areas.Read moreRead less