Expanding the organometallic toolbox for constructing heterocycles. This project aims to design and synthesise stereospecific cyclic molecules. This is a problem for chemists, particularly when bioactivity and medicinal relevance depend on complex stereochemistry and substitution patterns. This team will build on their discovery of a cascade reaction for synthesising highly stereospecific indolene derivatives. They will target reagents and reaction pathways for creating heterocyclic molecules wh ....Expanding the organometallic toolbox for constructing heterocycles. This project aims to design and synthesise stereospecific cyclic molecules. This is a problem for chemists, particularly when bioactivity and medicinal relevance depend on complex stereochemistry and substitution patterns. This team will build on their discovery of a cascade reaction for synthesising highly stereospecific indolene derivatives. They will target reagents and reaction pathways for creating heterocyclic molecules which are difficult to access. They will synthesise and characterise homo- and hetero-bimetallic complexes to develop cyclic molecules and scaffolds relevant in drug discovery. New molecules and reaction pathways will be relevant for biological and medicinal chemistry, and drug discovery programmes.Read moreRead less
Early main group organometallic complexes and their role in asymmetric synthesis. This project will develop new highly reactive metal based molecular tools for the controlled synthesis of complex molecules which are normally difficult to access, and in so doing advances our synthetic armoury. The design of the reaction pathways and final molecules will have relevance for modern medicinal chemistry and drug discovery programs.
Generation of Ultra-Clean Fuel from Victorian Brown Coal and Its Oxygen-Enriched Combustion Characteristics. Completion of this project can significantly contribute to the national priority of developing alternative energy technologies and ecologically sustainable power generation systems, as well as provide solutions to reduce and capture greenhouse gas emissions during Victorian brown coal firing. Improvements in the quality of Victorian brown coal and its value in national/international trad ....Generation of Ultra-Clean Fuel from Victorian Brown Coal and Its Oxygen-Enriched Combustion Characteristics. Completion of this project can significantly contribute to the national priority of developing alternative energy technologies and ecologically sustainable power generation systems, as well as provide solutions to reduce and capture greenhouse gas emissions during Victorian brown coal firing. Improvements in the quality of Victorian brown coal and its value in national/international trade markets can be achieved through the generation of ultra-clean fuel from coal. Substitution of ultra-clean fuel for Victorian brown coal in energy industries would greatly improve the competitiveness of the Victorian economy in a carbon-constrained future, and ensure power generation near-zero emissions.Read moreRead less
Designer Surfactants for Creation of Emulsion Properties. We propose new approaches to the design of surfactants for stabilising water in oil emulsions. New block copolymer surfactants may be "tailored" for head group structure and a pre-chosen hydrophilic/lipophilic balance at the oil-water interface using the Australian developed RAFT polymer synthesis method and polymeric inorganic species. The proposers have an extensive background in these areas.
X-ray and neutron scattering techniques, de ....Designer Surfactants for Creation of Emulsion Properties. We propose new approaches to the design of surfactants for stabilising water in oil emulsions. New block copolymer surfactants may be "tailored" for head group structure and a pre-chosen hydrophilic/lipophilic balance at the oil-water interface using the Australian developed RAFT polymer synthesis method and polymeric inorganic species. The proposers have an extensive background in these areas.
X-ray and neutron scattering techniques, developed by us, allow the interfacial structure of the surfactant to be found and the intellectual "loop" closed in the design process. Preliminary screening will be done using the surface balance and bulk emulsion synthesis.Read moreRead less
High Internal Phase Emulsions - Structure and Rheology Control. Our first SPIRT Grant with ORICA Australia Ltd has successfully identified nanostructures in high internal phase emulsions which confer useful stability and robustness on these industrially important systems. The aim now is to ramify those discoveries both scientifically and technologically in the design of emulsion structure using our, now established, techniques. In particular, the objective is to control both nanoscale and mes ....High Internal Phase Emulsions - Structure and Rheology Control. Our first SPIRT Grant with ORICA Australia Ltd has successfully identified nanostructures in high internal phase emulsions which confer useful stability and robustness on these industrially important systems. The aim now is to ramify those discoveries both scientifically and technologically in the design of emulsion structure using our, now established, techniques. In particular, the objective is to control both nanoscale and mesoscale structure in emulsion formulation, as well as the rheology and stability of emulsion preparations. To do this we plan to use mixed surfactant systems and to study intersurfactant synergic effects on the structure and fluidity of the interfacial material. We believe that the proposed work is unique and that the outcomes will be scientifically novel and also valuable for Australian industry.Read moreRead less
Multipurpose separation platforms for protein purification. Over the next decades, many new therapies and products will be needed to enhance the quality of human life. Biopharmaceuticals and other protein-based products will thus be increasingly in demand. This will require significant improvements in biotechnological procedures, particularly sophisticated purification technologies. Through the development of a novel technology, this project is anticipated to significantly contribute to these so ....Multipurpose separation platforms for protein purification. Over the next decades, many new therapies and products will be needed to enhance the quality of human life. Biopharmaceuticals and other protein-based products will thus be increasingly in demand. This will require significant improvements in biotechnological procedures, particularly sophisticated purification technologies. Through the development of a novel technology, this project is anticipated to significantly contribute to these societal needs and provide a new way to purify these important molecules. National and community benefits will accrue from this scientific innovation and from its application, which is expected to provide more efficient manufacturing opportunities for key biotechnology industries.Read moreRead less
Novel Technologies for the Purification of Recombinant Proteins. Availability of enabling technologies for the large-scale purification of recombinant proteins is an essential requirement of the biotechnology industry. This project aims to integrate two concepts in molecular biorecognition. New modalities of immobilised metal ion affinity chromatography will be linked with the selection of new types of peptide affinity handles that can be inserted by genetic engineering methods into proteins pro ....Novel Technologies for the Purification of Recombinant Proteins. Availability of enabling technologies for the large-scale purification of recombinant proteins is an essential requirement of the biotechnology industry. This project aims to integrate two concepts in molecular biorecognition. New modalities of immobilised metal ion affinity chromatography will be linked with the selection of new types of peptide affinity handles that can be inserted by genetic engineering methods into proteins produced by biotechnological procedures. The approach followed then allows these handles to be removed following isolation of the target protein. This project could thus lead to a considerable advance in the manufacture of recombinant proteins intended for human therapy.Read moreRead less
Next-generation latent fingermark detection using functional nanomaterials. Next-generation latent fingermark detection using functional nanomaterials. This project aims to develop a nanotechnology-based fingermark detection technique applicable in standard police laboratories and crime scenes. Current methods only detect half the fingermarks on an object, so many criminals are not identified. This project will use silicon oxide nanoparticles with a luminescent dye to target fingermark secretion ....Next-generation latent fingermark detection using functional nanomaterials. Next-generation latent fingermark detection using functional nanomaterials. This project aims to develop a nanotechnology-based fingermark detection technique applicable in standard police laboratories and crime scenes. Current methods only detect half the fingermarks on an object, so many criminals are not identified. This project will use silicon oxide nanoparticles with a luminescent dye to target fingermark secretion components and address interference from substrate chemistries and background luminescence. Moving away from traditional detection methods is expected to improve law enforcement outcomes, as fingermarks that current technologies cannot detect will be visualised for the first time.Read moreRead less
Chemistry of uranium extraction - studies on the dissolution of uranium ores in a complex solution matrix. Olympic Dam is the world's largest uranium deposit. With a planned massive expansion of the mine's operations, it could generate more than $10b per year. The mineral ores found there, however, are highly complex and poorly understood. This project will investigate and determine the detailed characteristics and chemistry of the mineral ore and offer process improvements that will increase th ....Chemistry of uranium extraction - studies on the dissolution of uranium ores in a complex solution matrix. Olympic Dam is the world's largest uranium deposit. With a planned massive expansion of the mine's operations, it could generate more than $10b per year. The mineral ores found there, however, are highly complex and poorly understood. This project will investigate and determine the detailed characteristics and chemistry of the mineral ore and offer process improvements that will increase the productivity and improve the economics of extraction of the ore. This project will also address the serious deficiency of researchers in this field by creating a sustainable skills development program in mineral extraction and separation technology.Read moreRead less
Investigation of the variation and origin of contaminants present in recycled PET. Recycling and waste management are of ever increasing concern in today's consumer society and our capacity to recycle waste is directly reliant on our ability to lower contamination levels and ensure consumer safety. Using novel analytical techniques, this project aims to characterise contaminants found in recycled PET and identify the source(s) of this contamination. Ultimately this will lead to a reduction in re ....Investigation of the variation and origin of contaminants present in recycled PET. Recycling and waste management are of ever increasing concern in today's consumer society and our capacity to recycle waste is directly reliant on our ability to lower contamination levels and ensure consumer safety. Using novel analytical techniques, this project aims to characterise contaminants found in recycled PET and identify the source(s) of this contamination. Ultimately this will lead to a reduction in recycled PET contamination levels, and allow a more complete recycling process. The global objective being to generate enough relevant scientific data to assist Visy in its endeavours to achieve higher levels of environmental performances and sustainable product development.Read moreRead less