Industrial Transformation Training Centres - Grant ID: IC170100016
Funder
Australian Research Council
Funding Amount
$3,123,492.00
Summary
ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therap ....ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therapeutics. The use of an individual patient’s cellular and molecular research findings will ultimately enable personalised diagnostic and therapeutic decisions.Read moreRead less
Consequences of water reform and changing farm adaptation in the Basin. This project aims to evaluate the consequences of, and lessons learned from, the past two decades of water reform in the Murray-Darling Basin (MDB). In particular, it will examine the recent economic and farm consequences of water recovery. Australia is over halfway through implementation of the MDB Plan, and has spent over $6 billion in water recovery to achieve basin-wide resilience, with billions more still committed. Pro ....Consequences of water reform and changing farm adaptation in the Basin. This project aims to evaluate the consequences of, and lessons learned from, the past two decades of water reform in the Murray-Darling Basin (MDB). In particular, it will examine the recent economic and farm consequences of water recovery. Australia is over halfway through implementation of the MDB Plan, and has spent over $6 billion in water recovery to achieve basin-wide resilience, with billions more still committed. Project expected outcomes include pioneering new methods to track how MDB irrigation efficiency, productivity and other farm outcomes have changed as a response to water reform. It will also draw lessons from both national and international case studies to consequently inform more effective water management.Read moreRead less
The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling f ....The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling for a synergistic defence to adapt to the nanoparticle toxicity. The pioneering knowledge is the foundation for technologies targeting the interspecies metabolite cross-talking to overcome the resistance phenomena, ensuring a long-term efficacy of the alternative antimicrobial on the difficult-to-control pathogenic growth.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100137
Funder
Australian Research Council
Funding Amount
$881,758.00
Summary
Australian Environmental Specimen Bank: advancing specimen bank capability. The aim of this LIEF is to advance Australia’s specimen banking capabilities through a new, enhanced national facility, the Australian Environmental Specimen Bank (AESB). The AESB would be founded on a unique current archive of human and environmental samples established by the partners to the LIEF. Importantly, the AESB would be managed as a nationally available (to all public sector researchers), operationally self-fun ....Australian Environmental Specimen Bank: advancing specimen bank capability. The aim of this LIEF is to advance Australia’s specimen banking capabilities through a new, enhanced national facility, the Australian Environmental Specimen Bank (AESB). The AESB would be founded on a unique current archive of human and environmental samples established by the partners to the LIEF. Importantly, the AESB would be managed as a nationally available (to all public sector researchers), operationally self-funded resource for integrated exposure research into the future. The archive is expected to support longitudinal and cross-sectional studies to assess trends in exposure to chemical and biological hazards in the Australian population, identify emerging hazards, and provide a scientific basis for policy and regulatory actions.Read moreRead less
Protein biosensors for detecting smoke exposure of grapes. Bush fires and controlled burns that take place in the vicinity of vineyards can lead to grape contamination with tasteless phenolic glucosides. Their hydrolysis during wine making leads to “smoke taint” – an unpleasant medicinal taste that can render wine undrinkable. We will apply a combination of organic synthesis, protein engineering and directed evolution to develop protein-based biosensors of phenolic glucosides. These biosensors w ....Protein biosensors for detecting smoke exposure of grapes. Bush fires and controlled burns that take place in the vicinity of vineyards can lead to grape contamination with tasteless phenolic glucosides. Their hydrolysis during wine making leads to “smoke taint” – an unpleasant medicinal taste that can render wine undrinkable. We will apply a combination of organic synthesis, protein engineering and directed evolution to develop protein-based biosensors of phenolic glucosides. These biosensors will be used to devise a simple portable colorimetric test that can be performed in the vineyard or the winery. The ability to rapidly determine the level of grape contamination with phenolic glucosides would give Australian wine growers and wine makers a powerful tool to mitigate the effects of bushfires.Read moreRead less
Exploring Wellbeing Outcomes in the Aquatic and Recreation Industry. This project aims to investigate the impact on individual wellbeing through use of public aquatic and recreation centres in Australia. Through the use of mixed methods across multiple locations, the project expects to generate new knowledge on the effect on users of different management and service models for the provision of aquatic and recreational infrastructure. Expected outcomes include a quantifiable measure of social and ....Exploring Wellbeing Outcomes in the Aquatic and Recreation Industry. This project aims to investigate the impact on individual wellbeing through use of public aquatic and recreation centres in Australia. Through the use of mixed methods across multiple locations, the project expects to generate new knowledge on the effect on users of different management and service models for the provision of aquatic and recreational infrastructure. Expected outcomes include a quantifiable measure of social and emotional wellbeing that can be utilised by centre management and government. This will help assessment of best practice for maximising community wellbeing, and can guide investment decisions by state and local government.Read moreRead less
Realising Australia’s rare earth resource potential. This project aims to reveal the potential for undiscovered economic deposits of rare earth elements within the Australian continent. Future supply of these elements underpins societies transition to clean energy and embrace of high-tech applications. The project expects to greatly enhance our knowledge of Australia’s endowment of rare earth element resources using an array of traditional and innovative geological research methods. Expected out ....Realising Australia’s rare earth resource potential. This project aims to reveal the potential for undiscovered economic deposits of rare earth elements within the Australian continent. Future supply of these elements underpins societies transition to clean energy and embrace of high-tech applications. The project expects to greatly enhance our knowledge of Australia’s endowment of rare earth element resources using an array of traditional and innovative geological research methods. Expected outcomes of this project include a greater understanding of how, where and when rare earth element orebodies form in the Earth's crust. This should provide significant benefits to exploring for––and discovering––new orebodies that are required to secure global critical metal supplies. Read moreRead less
ARC Centre of Excellence in Synthetic Biology. The ARC Centre of Excellence in Synthetic Biology (CoESB) will provide the technical innovation critical for Australia to develop a vibrant bioeconomy building on the nation’s strengths in agriculture. For thousands of years we have used microbes to create bread, wine, cheese. Now, our Centre will pioneer new approaches to the design of synthetic microbes, enabling the development of custom-designed microbial communities, synthetic organelles and ne ....ARC Centre of Excellence in Synthetic Biology. The ARC Centre of Excellence in Synthetic Biology (CoESB) will provide the technical innovation critical for Australia to develop a vibrant bioeconomy building on the nation’s strengths in agriculture. For thousands of years we have used microbes to create bread, wine, cheese. Now, our Centre will pioneer new approaches to the design of synthetic microbes, enabling the development of custom-designed microbial communities, synthetic organelles and new to nature biological pathways and enzymes. CoESB will combine engineering with molecular biology to design and construct novel biological systems that can convert biomass from agriculture or waste streams to biofuel, bioplastics and other high-value chemicals.Read moreRead less
Mapping mineral systems of deep Australia. We aim at enabling mineral resource discoveries by calibrating geophysical surveys using geochemical and petrophysical properties measured on mantle samples brought to the surface by recent volcanoes. National geophysical surveys deliver images of geophysical gradients in the deeper part of the Australian continent. The interpretation of these gradients in geological terms and in terms of economic mineral systems is the key to unlock deep exploration su ....Mapping mineral systems of deep Australia. We aim at enabling mineral resource discoveries by calibrating geophysical surveys using geochemical and petrophysical properties measured on mantle samples brought to the surface by recent volcanoes. National geophysical surveys deliver images of geophysical gradients in the deeper part of the Australian continent. The interpretation of these gradients in geological terms and in terms of economic mineral systems is the key to unlock deep exploration success. This project will turn Australia’s investment in National geophysical surveys into new discoveries of base metals. The benefit stems from enabling the transition to a clean economy which requires a much broader range of critical minerals and a larger quantity of base metals.Read moreRead less
The carbonate geology of the critical metal niobium. This project aims to understand how pyrochlore, the major ore mineral of the critical metal niobium, forms in
Earth’s crust. Niobium is exclusively mined from carbonatite magma bodies in Brazil and Canada, despite proven
Australian resources. It is used in high strength steel alloys in the construction and transport industries. Expected
research outcomes include understanding how pyrochlore forms in carbonatites, development of exploration too ....The carbonate geology of the critical metal niobium. This project aims to understand how pyrochlore, the major ore mineral of the critical metal niobium, forms in
Earth’s crust. Niobium is exclusively mined from carbonatite magma bodies in Brazil and Canada, despite proven
Australian resources. It is used in high strength steel alloys in the construction and transport industries. Expected
research outcomes include understanding how pyrochlore forms in carbonatites, development of exploration tools
to locate niobium ore bodies which are unexposed at the surface, and investigation of environmentally and
economically sustainable technologies for metallurgical extraction of niobium from ore. The research is intended
to benefit Australia’s critical metals exploration and mining industries.Read moreRead less