Consequences of water reform and changing farm adaptation in the Basin. This project aims to evaluate the consequences of, and lessons learned from, the past two decades of water reform in the Murray-Darling Basin (MDB). In particular, it will examine the recent economic and farm consequences of water recovery. Australia is over halfway through implementation of the MDB Plan, and has spent over $6 billion in water recovery to achieve basin-wide resilience, with billions more still committed. Pro ....Consequences of water reform and changing farm adaptation in the Basin. This project aims to evaluate the consequences of, and lessons learned from, the past two decades of water reform in the Murray-Darling Basin (MDB). In particular, it will examine the recent economic and farm consequences of water recovery. Australia is over halfway through implementation of the MDB Plan, and has spent over $6 billion in water recovery to achieve basin-wide resilience, with billions more still committed. Project expected outcomes include pioneering new methods to track how MDB irrigation efficiency, productivity and other farm outcomes have changed as a response to water reform. It will also draw lessons from both national and international case studies to consequently inform more effective water management.Read moreRead less
Coexisting with Coronaviruses: Rethinking the Emergence of the Pandemic. Before COVID-19 disrupted modern life, benign coronaviruses were circulating among people and animals in Southeast Asia. As medical researchers work to control the spread of this infectious disease, multispecies ethnography has a special role to play in generating basic knowledge about coronaviruses. This project aims to understand how interactions between people and multiple animal species generated a virus with pandemic p ....Coexisting with Coronaviruses: Rethinking the Emergence of the Pandemic. Before COVID-19 disrupted modern life, benign coronaviruses were circulating among people and animals in Southeast Asia. As medical researchers work to control the spread of this infectious disease, multispecies ethnography has a special role to play in generating basic knowledge about coronaviruses. This project aims to understand how interactions between people and multiple animal species generated a virus with pandemic potential. Approaches from science studies and the environmental humanities will generate conceptual innovations related to three themes: viral visibility, coexistence, and pathogen emergence. Innovations in multispecies methods should produce knowledge about viruses with broad benefits that may safeguard future health.Read moreRead less
Harnessing light and electricity to drive chemical synthesis. This project will explore and establish original strategies that use inputs of energy (light and electricity) to break or form chemical bonds, which can provide new or improved access to valuable compounds. In this way, this research will augment or enhance existing methods for the selective and direct manipulation of molecules by creating tools that allow chemists to prepare molecules under particularly mild conditions. The outcomes ....Harnessing light and electricity to drive chemical synthesis. This project will explore and establish original strategies that use inputs of energy (light and electricity) to break or form chemical bonds, which can provide new or improved access to valuable compounds. In this way, this research will augment or enhance existing methods for the selective and direct manipulation of molecules by creating tools that allow chemists to prepare molecules under particularly mild conditions. The outcomes of the project will include the development of new technology for organic synthesis and forging novel approaches for chemical alkylation and cross-coupling reactions. This can contribute to making important compounds more efficiently, safely and cheaper to produce in the future.Read moreRead less
Illuminating genomic dark matter to develop new interventions for parasites. This project aims to unravel the molecular basis of parasitism using leading-edge post-genomics approaches. This research expects to explore genomic ‘dark matter’ in the genome to discover how parasites survive and cause disease. The resultant shift in the understanding of molecular mechanisms and processes governing parasitism will lead to new ways of disrupting the intricate parasite-host relationship, which will tran ....Illuminating genomic dark matter to develop new interventions for parasites. This project aims to unravel the molecular basis of parasitism using leading-edge post-genomics approaches. This research expects to explore genomic ‘dark matter’ in the genome to discover how parasites survive and cause disease. The resultant shift in the understanding of molecular mechanisms and processes governing parasitism will lead to new ways of disrupting the intricate parasite-host relationship, which will translate into innovative technologies or products to ameliorate the burden of parasites in livestock animals. Expected socioeconomic benefits include lifting Australia’s scientific knowledge base, reputation in biology and biotechnology, livestock production and investment in translational research.Read moreRead less
Consumer and Community Involvement Process Implementation Model . The project aims to examine the barriers and enablers to Consumer and Community Involvement. We will generate new knowledge via innovative methods from narrative medicine and economic and marketing studies including establishing the first Community of Practice for consumers and stakeholders in dementia research as the example. The outcomes include the creation of a process implementation model for Consumer and Community Involvemen ....Consumer and Community Involvement Process Implementation Model . The project aims to examine the barriers and enablers to Consumer and Community Involvement. We will generate new knowledge via innovative methods from narrative medicine and economic and marketing studies including establishing the first Community of Practice for consumers and stakeholders in dementia research as the example. The outcomes include the creation of a process implementation model for Consumer and Community Involvement to inform policies and guidelines for research systems and funding. This process model will propel research forward and generate opportunities to maximise the health and social benefits of research, including significant translation of research into practice. Read moreRead less
Defining novel immune checkpoints controlled by stromal cells. This project seeks to use innovative approaches to elucidate the mechanisms that define the earliest steps required to generate immune responses. The proposal builds on discoveries, including novel preliminary data, from a team with world-leading expertise in immunology, virology and stromal cell biology. The expected findings will provide fundamental insights into novel cellular and molecular interactions between stromal tissue comp ....Defining novel immune checkpoints controlled by stromal cells. This project seeks to use innovative approaches to elucidate the mechanisms that define the earliest steps required to generate immune responses. The proposal builds on discoveries, including novel preliminary data, from a team with world-leading expertise in immunology, virology and stromal cell biology. The expected findings will provide fundamental insights into novel cellular and molecular interactions between stromal tissue components and immune cells that initiate and regulate immune responses. Expected benefits include fundamental advances in knowledge, as well as insights that will ultimately benefit biotechnology and therapeutic applications, and in this way support research priorities linked to advanced manufacturing and health.
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Charging transition metals with activating alkanes. The project aims to engineer positively charged metal complexes and use them to explore the chemistry of bound activated alkane ligands. The transformation of cheap, plentiful alkanes into more valuable products is a major quest in chemistry, and complexes of alkanes bound to metals are expected to play a key role in transformations of alkanes. The project intends to use the activated metal bound alkane to transform the normally inert alkane in ....Charging transition metals with activating alkanes. The project aims to engineer positively charged metal complexes and use them to explore the chemistry of bound activated alkane ligands. The transformation of cheap, plentiful alkanes into more valuable products is a major quest in chemistry, and complexes of alkanes bound to metals are expected to play a key role in transformations of alkanes. The project intends to use the activated metal bound alkane to transform the normally inert alkane into compounds with desirable functional groups. This should make the synthesis of alkane complexes stable at room temperature in solution a realistic possibility. These cheap, plentiful alkanes can be turned into more valuable products, bringing benefits to industry.Read moreRead less