Coexisting with Coronaviruses: Rethinking the Emergence of the Pandemic. Before COVID-19 disrupted modern life, benign coronaviruses were circulating among people and animals in Southeast Asia. As medical researchers work to control the spread of this infectious disease, multispecies ethnography has a special role to play in generating basic knowledge about coronaviruses. This project aims to understand how interactions between people and multiple animal species generated a virus with pandemic p ....Coexisting with Coronaviruses: Rethinking the Emergence of the Pandemic. Before COVID-19 disrupted modern life, benign coronaviruses were circulating among people and animals in Southeast Asia. As medical researchers work to control the spread of this infectious disease, multispecies ethnography has a special role to play in generating basic knowledge about coronaviruses. This project aims to understand how interactions between people and multiple animal species generated a virus with pandemic potential. Approaches from science studies and the environmental humanities will generate conceptual innovations related to three themes: viral visibility, coexistence, and pathogen emergence. Innovations in multispecies methods should produce knowledge about viruses with broad benefits that may safeguard future health.Read moreRead less
Illuminating genomic dark matter to develop new interventions for parasites. This project aims to unravel the molecular basis of parasitism using leading-edge post-genomics approaches. This research expects to explore genomic ‘dark matter’ in the genome to discover how parasites survive and cause disease. The resultant shift in the understanding of molecular mechanisms and processes governing parasitism will lead to new ways of disrupting the intricate parasite-host relationship, which will tran ....Illuminating genomic dark matter to develop new interventions for parasites. This project aims to unravel the molecular basis of parasitism using leading-edge post-genomics approaches. This research expects to explore genomic ‘dark matter’ in the genome to discover how parasites survive and cause disease. The resultant shift in the understanding of molecular mechanisms and processes governing parasitism will lead to new ways of disrupting the intricate parasite-host relationship, which will translate into innovative technologies or products to ameliorate the burden of parasites in livestock animals. Expected socioeconomic benefits include lifting Australia’s scientific knowledge base, reputation in biology and biotechnology, livestock production and investment in translational research.Read moreRead less
Consumer and Community Involvement Process Implementation Model . The project aims to examine the barriers and enablers to Consumer and Community Involvement. We will generate new knowledge via innovative methods from narrative medicine and economic and marketing studies including establishing the first Community of Practice for consumers and stakeholders in dementia research as the example. The outcomes include the creation of a process implementation model for Consumer and Community Involvemen ....Consumer and Community Involvement Process Implementation Model . The project aims to examine the barriers and enablers to Consumer and Community Involvement. We will generate new knowledge via innovative methods from narrative medicine and economic and marketing studies including establishing the first Community of Practice for consumers and stakeholders in dementia research as the example. The outcomes include the creation of a process implementation model for Consumer and Community Involvement to inform policies and guidelines for research systems and funding. This process model will propel research forward and generate opportunities to maximise the health and social benefits of research, including significant translation of research into practice. Read moreRead less
Defining novel immune checkpoints controlled by stromal cells. This project seeks to use innovative approaches to elucidate the mechanisms that define the earliest steps required to generate immune responses. The proposal builds on discoveries, including novel preliminary data, from a team with world-leading expertise in immunology, virology and stromal cell biology. The expected findings will provide fundamental insights into novel cellular and molecular interactions between stromal tissue comp ....Defining novel immune checkpoints controlled by stromal cells. This project seeks to use innovative approaches to elucidate the mechanisms that define the earliest steps required to generate immune responses. The proposal builds on discoveries, including novel preliminary data, from a team with world-leading expertise in immunology, virology and stromal cell biology. The expected findings will provide fundamental insights into novel cellular and molecular interactions between stromal tissue components and immune cells that initiate and regulate immune responses. Expected benefits include fundamental advances in knowledge, as well as insights that will ultimately benefit biotechnology and therapeutic applications, and in this way support research priorities linked to advanced manufacturing and health.
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Physics-based equivalent circuit models for nanoporous electrodes. This project aims to develop new physics-based equivalent circuit models for ion/electron coupled dynamics in electrified porous nanomaterials via fusing latest simulation advances with machine learning approach. This project expects to meet the challenge of high-efficient and accurate dynamic models for accelerated design, accurate diagnosis, and optimal operation of electrochemical energy storage and conversion technologies. Th ....Physics-based equivalent circuit models for nanoporous electrodes. This project aims to develop new physics-based equivalent circuit models for ion/electron coupled dynamics in electrified porous nanomaterials via fusing latest simulation advances with machine learning approach. This project expects to meet the challenge of high-efficient and accurate dynamic models for accelerated design, accurate diagnosis, and optimal operation of electrochemical energy storage and conversion technologies. The outcome will be a paradigm shift of how equivalent circuit models are developed and used, informed by new scientific knowledge and data. The proliferation of the new models will allow design and operation of more efficient and durable technologies in energy industry, benefitting Australian economy and environment.Read moreRead less
Metabolic control of gene expression networks and microbiome interactions. The proposal aims to advance our understanding of how metabolism (and resulting metabolites) regulate the expression of genes, and investigate how these processes dictate the interaction of microbiota with the immune system. The project is expected to generate transformative knowledge of gene regulation, a fundamental process for cellular function, and decipher how the microbiome yeast Candida albicans interacts with immu ....Metabolic control of gene expression networks and microbiome interactions. The proposal aims to advance our understanding of how metabolism (and resulting metabolites) regulate the expression of genes, and investigate how these processes dictate the interaction of microbiota with the immune system. The project is expected to generate transformative knowledge of gene regulation, a fundamental process for cellular function, and decipher how the microbiome yeast Candida albicans interacts with immune cells and bacteria. By utilising a powerful combination of molecular and systems biology with molecular genetics and imaging, the project outcomes should foster interdisciplinary collaborations and build capacity for fundamental and applied research to benefit academia and industry, locally and globally.Read moreRead less
Correlative Imaging of Brain Lipids. This project aims to develop imaging tools and protocols for the detection of lipids in brain tissue and cells. This project expects to generate advanced methodologies to display specific lipid classes and their corresponding structures within tissues and cells, with the ability to be detected and correlated with multiple techniques, which represent a currently unavailable capacity. The expected outcomes of this project are improved opportunities to study lip ....Correlative Imaging of Brain Lipids. This project aims to develop imaging tools and protocols for the detection of lipids in brain tissue and cells. This project expects to generate advanced methodologies to display specific lipid classes and their corresponding structures within tissues and cells, with the ability to be detected and correlated with multiple techniques, which represent a currently unavailable capacity. The expected outcomes of this project are improved opportunities to study lipid biology at the cellular and sub-cellular level across a wide range of in vitro and in vivo models. The outcomes of this project should provide significant knowledge to tackle modern societal challenges in healthy ageing, brain pathologies and neurodegenerative diseases.Read moreRead less
The transcriptome dynamics that refine eukaryotic gene expression. This project aims to understand the fundamental mechanisms of gene expression control, by exploring how cells respond to acute perturbation with changes to RNA expression and processing. Unlike the static information encoded within the genome, the information encoded in its intermediary RNA, is transient, plastic and responsive to environmental and developmental cues. This project will use new technologies encompassing RNA-bioche ....The transcriptome dynamics that refine eukaryotic gene expression. This project aims to understand the fundamental mechanisms of gene expression control, by exploring how cells respond to acute perturbation with changes to RNA expression and processing. Unlike the static information encoded within the genome, the information encoded in its intermediary RNA, is transient, plastic and responsive to environmental and developmental cues. This project will use new technologies encompassing RNA-biochemistry, Next Generation Sequencing, and bioinformatics to answer long-standing questions in RNA processing. The project expects to significantly enhance our understanding of the mechanisms underpinning gene-expression control, benefitting Australia by positioning it as a world leader in the field of RNA Biology.Read moreRead less
China’s Law-Based Governance Revolution under Xi Jinping . To sustain its unmitigated power, the Chinese Communist Party is transforming its legal ideology and governance focus to make politico-legal institutions more capable of supervising and moulding people’s behaviour and beliefs. This project aims to examine how this transformation is constructed by key institutions and digested into public policy and legal decision-making guidelines. It expects to generate new knowledge on how Xi Jinping-e ....China’s Law-Based Governance Revolution under Xi Jinping . To sustain its unmitigated power, the Chinese Communist Party is transforming its legal ideology and governance focus to make politico-legal institutions more capable of supervising and moulding people’s behaviour and beliefs. This project aims to examine how this transformation is constructed by key institutions and digested into public policy and legal decision-making guidelines. It expects to generate new knowledge on how Xi Jinping-era legal ideology guides policy and decision-making in China. The expected outcomes include an enhanced conceptual and empirical understanding of politico-legal change in China. This project has significant implications for Australia given China’s increasingly assertive role in international governance. Read moreRead less