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ENDOGENOUS PAIN RELIEF IN HEALTHY AND OSTEOARTHRITIC PATIENTS
Funder
National Health and Medical Research Council
Funding Amount
$509,926.00
Summary
Pain has a detrimental impact on ones quality of life and a significant financial impact on the community. Given this, there is a substantial effort aimed at developing pain relieving compounds. One way in which our own brain can provide complete pain relief is via a mechanism called diffuse noxious inhibitory control. We currently do not know how this mechanism works and the aim of this investigation is to explore this mechanism in healthy and osteoarthritis patients use human brain imaging.
Does Low Dose Amitriptyline Reduce Pain In Knee Osteoarthritis? A Double Blind, Randomised, Pragmatic, Placebo Controlled Clinical Trial Of Amitriptyline In Addition To Usual Care
Funder
National Health and Medical Research Council
Funding Amount
$413,704.00
Summary
Pain is the main problem for people with osteoarthritis, a common form of arthritis. This pain is not controlled well. Pain comes from structural changes in the joint. However, after time, some people develop pain due to changes in the nervous system, called pain sensitisation. This is not affected by usual treatments. Amitriptyline is used to treat pain sensitisation. This study is a randomised trial to see whether amitriptyline, relieves pain in people with knee osteoarthritis over 3 months.
A Randomised Trial Of Zoledronic Acid For Osteoarthritis Of The Knee
Funder
National Health and Medical Research Council
Funding Amount
$989,238.00
Summary
Osteoarthritis (OA) is the most common form of arthritis and is increasing markedly due to an ageing population. Despite its large disease burden, there are currently no approved disease-modifying drugs available which modify structural progression of OA. The aim of this study is to compare zoledronic acid treatment to placebo on knee structural change and knee pain over two years. It is hypothesised that zoledronic acid will reduce cartilage loss, knee pain, and bone marrow lesion size.
Unloading Shoes For Knee Osteoarthritis: A Double-blind Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$772,743.00
Summary
This is a clinical trial that will evaluate the effectiveness of unloading shoes for managing the symptoms of knee osteoarthritis. This trial will evaluate whether unloading shoes can reduce pain and physical dysfunction, compared to control (non-unloading) shoes, after 6 months. Patient characteristics that may influence the effectiveness of the unloading shoes will also be evaluated. If effective, unloading shoes could be made commercially available as a self-management strategy to patients wi ....This is a clinical trial that will evaluate the effectiveness of unloading shoes for managing the symptoms of knee osteoarthritis. This trial will evaluate whether unloading shoes can reduce pain and physical dysfunction, compared to control (non-unloading) shoes, after 6 months. Patient characteristics that may influence the effectiveness of the unloading shoes will also be evaluated. If effective, unloading shoes could be made commercially available as a self-management strategy to patients with knee osteoarthritis .Read moreRead less
Hype Or Hope? Platelet-Rich Plasma As A Symptom- And DisEaSe-modifying Treatment FOR Knee OstEoarthritis - The RESTORE Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,400,359.00
Summary
Knee osteoarthritis (OA) is a major public health problem worldwide with no cure. Thus safe and effective treatments that reduce symptoms and slow structural disease progression are needed. This clinical trial aims to test the effects of injections of platelet-rich plasma (a blood product) into the knee on pain and joint structure in 288 people with knee OA. The results will provide high quality evidence to determine whether platelet rich plasma should be used to treat knee OA.
Footwear For Self-managing Knee Osteoarthritis Symptoms: The Footstep Trial
Funder
National Health and Medical Research Council
Funding Amount
$590,532.00
Summary
Self-management of symptoms is an important part of treatment for people with knee osteoarthritis. Footwear influences forces across the knee joint and it is unclear which types of shoes are best to minimise arthritis symptoms. This study will compare the effects of flat flexible shoes to stable supportive shoe styles on pain and physical function over 6 months in people with painful knee osteoarthritis.
Can Shoe Inserts Reduce The Burden Of Kneecap Osteoarthritis?
Funder
National Health and Medical Research Council
Funding Amount
$644,550.00
Summary
Kneecap arthritis is a leading cause of pain, disability and health expenditure in the Australian community. ‘Off-the-shelf’ shoe inserts are simple, low-cost devices that can reduce kneecap pain in young adults, and are accessible to all Australians. This project investigates whether ‘off-the-shelf’ shoe inserts improve pain in older adults with kneecap arthritis over 12 months, and evaluates the relationship between cost and patient benefits.
A Randomised Trial Of Krill Oil For Osteoarthritis Of The Knee
Funder
National Health and Medical Research Council
Funding Amount
$751,491.00
Summary
This study trials krill oil vs placebo, for painful knee osteoarthritis in people with joint swelling on MRI scans, to assess if krill oil reduces knee pain and knee swelling over 24 weeks. If krill oil can delay loss of knee cartilage through effects on cartilage and bone, this this could lead to a delay in the time to knee replacement surgery and improvements in quality of life for those suffering from OA.
Train High Eat Low For Osteoarthritis (THE LO Study): A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$592,496.00
Summary
Generic lifestyle prescriptions are both insufficient and unrealistic in a cohort that is obese and markedly impaired in mobility and activity level due to lower extremity pain and abnormalities of gait. Therefore this study will design and test for the first time a novel, evidence-based lifestyle modification program which targets all of the treatable etiologic factors in knee OA: low Glycemic Index/Glycemic Load (GI/GL) diet, high intensity strength training and gait training.
DICKENS - A Randomised Controlled Trial Of DIaCerein To Treat KneE Osteoarthritis With EffusioN-Synovitis
Funder
National Health and Medical Research Council
Funding Amount
$1,327,836.00
Summary
Knee osteoarthritis (OA) is common, but the current treatments are poor. Almost 60% of people with knee OA have joint inflammation. Patients with inflammation are more likely to experience joint pain and rapid joint destruction. We propose that treating patients with inflammatory knee OA with the anti-inflammatory drug, diacerein, will reduce pain and joint damage.