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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882634
Funder
Australian Research Council
Funding Amount
$220,000.00
Summary
Integrated Process Intensification Facility. The new equipment will provide a unique facility for process intensification (PI). No other techniques are capable of controlling features of nano-particles (size, shape, agglomeration, phases and defects) under continuous flow, which is essential for applications in nano-technology. There are unique capabilities of PI in chemical synthesis, including drug development and drug discovery. Overall, applications of PI cover health care products, device t ....Integrated Process Intensification Facility. The new equipment will provide a unique facility for process intensification (PI). No other techniques are capable of controlling features of nano-particles (size, shape, agglomeration, phases and defects) under continuous flow, which is essential for applications in nano-technology. There are unique capabilities of PI in chemical synthesis, including drug development and drug discovery. Overall, applications of PI cover health care products, device technology, and more, for the benefit of the community at large. The facility will foster a more innovative research culture and provide excellent research training at the highest international level, and will provide a platform to foster greater links with industry.Read moreRead less
Generation of Novel Fermentation Products and their Exploitation in the Synthesis of Biologically Active Organic Compounds with Therapeutic Potential. Collections of new micro-organisms and their metabolites suitable for use in the chemical synthesis programs will emerge from the proposed research. This will provide a potentially highly-valuable national resource that could serve the needs of many laboratories around Australia by allowing them to establish more direct routes to target molecules ....Generation of Novel Fermentation Products and their Exploitation in the Synthesis of Biologically Active Organic Compounds with Therapeutic Potential. Collections of new micro-organisms and their metabolites suitable for use in the chemical synthesis programs will emerge from the proposed research. This will provide a potentially highly-valuable national resource that could serve the needs of many laboratories around Australia by allowing them to establish more direct routes to target molecules being sought in the development of new therapeutic agents and/or materials. The combined application of molecular biological, microbiological and chemical synthesis techniques in a concerted manner in the one location will lead to a raft of new opportunities for the biotech and pharmaceutical industries in Australia.Read moreRead less
Generation of Novel Fermentation Products and their Exploitation in the Synthesis of Biologically Active Organic Compounds with Therapeutic Potential. Collections of new micro-organisms and their metabolites suitable for use in the chemical synthesis programs will emerge from the proposed research. This will provide a potentially highly-valuable national resource that could serve the needs of many laboratories around Australia by allowing them to establish more direct routes to target molecules ....Generation of Novel Fermentation Products and their Exploitation in the Synthesis of Biologically Active Organic Compounds with Therapeutic Potential. Collections of new micro-organisms and their metabolites suitable for use in the chemical synthesis programs will emerge from the proposed research. This will provide a potentially highly-valuable national resource that could serve the needs of many laboratories around Australia by allowing them to establish more direct routes to target molecules being sought in the development of new therapeutic agents and/or materials. The combined application of molecular biological, microbiological and chemical synthesis techniques in a concerted manner in the one location will lead to a raft of new opportunities for the biotech and pharmaceutical industries in Australia. Read moreRead less
Synthesis and Production of High Value Pyridines Combining the Concepts of Alternative Reaction Media and Process Intensification. This project aims to develop novel syntheses and process route for substituted pyridines by bringing together expertise in the fields of green chemistry and process intensification. Minimisation of waste, energy efficiency, and improved selectivity and control will be the key process and chemistry targets, which will produce high value compounds. Traditional approach ....Synthesis and Production of High Value Pyridines Combining the Concepts of Alternative Reaction Media and Process Intensification. This project aims to develop novel syntheses and process route for substituted pyridines by bringing together expertise in the fields of green chemistry and process intensification. Minimisation of waste, energy efficiency, and improved selectivity and control will be the key process and chemistry targets, which will produce high value compounds. Traditional approaches use organic solvents and preformed salts which are costly, generate waste and the processes are energy intensive due to poor selectivity, low yield and extensive separation steps. This is a generic investigation which will have wide ranging applications in the pharmaceutical, energy and advanced electronic industries.Read moreRead less
Application of process intensification on rotating surfaces (PIRS) in organic synthesis. Process intensification technologies in the form of SDP and RTP are new to Australia and present many opportunities for carrying out the synthesis of organic compounds. They have remarkable versatility in being able to control chemical reactions with greater selectivity than using classical batch technology, at the same time allowing access to new compounds. Moreover, the technologies embrace the principles ....Application of process intensification on rotating surfaces (PIRS) in organic synthesis. Process intensification technologies in the form of SDP and RTP are new to Australia and present many opportunities for carrying out the synthesis of organic compounds. They have remarkable versatility in being able to control chemical reactions with greater selectivity than using classical batch technology, at the same time allowing access to new compounds. Moreover, the technologies embrace the principles of green chemistry in minimising the generation of waste, while operating under continuous flow which is destined to be more attractive to industry. This is likely in the fine chemicals sector, and in drug discovery. The project will provide first-rate research training and promote Australian science. Read moreRead less
Integrated self assembly processes and spinning disc reactor technology. Spinning Disc Reactor technology is new to Australia and will have wide ranging applications in nano-technology and in developing benign industrial chemical processes with smaller footprint and significantly reduced capital outlay. The cutting edge research will foster collaboration with industry, and lead to establishing new industries in device technology, smart materials, health care products, catalysis and energy storag ....Integrated self assembly processes and spinning disc reactor technology. Spinning Disc Reactor technology is new to Australia and will have wide ranging applications in nano-technology and in developing benign industrial chemical processes with smaller footprint and significantly reduced capital outlay. The cutting edge research will foster collaboration with industry, and lead to establishing new industries in device technology, smart materials, health care products, catalysis and energy storage, through exploiting commercial opportunities. The project will provide excellent research training in a range of scientific skills and in professional development, and will involve overseas PhD exchange programs. The exciting research incorporating benign metrics will enhance public opinion towards science. Read moreRead less
gem-Dihalogenocyclopropanes as building blocks for the chemical synthesis of biologically active natural products and their analogues. New and efficient methods for the assembly of biologically active compounds will emerge from this research and thus provide materials for evaluation as potential therapeutics in the treatment of a range of pathological conditions including Alzheimer's disease and certain types of lung cancers that respond poorly to currently available treatments. The underpinning ....gem-Dihalogenocyclopropanes as building blocks for the chemical synthesis of biologically active natural products and their analogues. New and efficient methods for the assembly of biologically active compounds will emerge from this research and thus provide materials for evaluation as potential therapeutics in the treatment of a range of pathological conditions including Alzheimer's disease and certain types of lung cancers that respond poorly to currently available treatments. The underpinning methodologies are also likely to provide opportunities in other areas, including materials science. The training of a highly capable post-doctoral in chemical synthesis, an area where there is now an extraordinary and unsatisfied demand for such expertise, will be a further benefit of the proposed program of research.Read moreRead less
Process for treatment of fluorine-containing synthetic greenhouse gases. It is generally agreed that increasing levels of greenhouse gases in the atmosphere are leading to higher average atmospheric temperatures. This research pursues the development of an energy-efficient, non-destructive process for transforming fluorine-containing greenhouse gases (GHGs) into valuable and environmentally benign products. The application of research will lead to the development of a new non-destructive proce ....Process for treatment of fluorine-containing synthetic greenhouse gases. It is generally agreed that increasing levels of greenhouse gases in the atmosphere are leading to higher average atmospheric temperatures. This research pursues the development of an energy-efficient, non-destructive process for transforming fluorine-containing greenhouse gases (GHGs) into valuable and environmentally benign products. The application of research will lead to the development of a new non-destructive process and will benefit Australia, socially by reducing emission of GHGs and thus protecting the environment, and economically through licensing of the technology for treatment of the growing stockpiles of synthetic GHGs.
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Particle motion and particle-convective heat transfer near the walls of fluidized beds. Background: Fluidized bed technology has important industrial applications ranging from petrol production to mineral processing for metal production. Such processes take advantage of the high rates of heat transfer in gas-fluidized beds.
Objective of project: To improve understanding and modelling of heat transfer in gas fluidized beds through the application of state-of-the-art experimental (Positron Emiss ....Particle motion and particle-convective heat transfer near the walls of fluidized beds. Background: Fluidized bed technology has important industrial applications ranging from petrol production to mineral processing for metal production. Such processes take advantage of the high rates of heat transfer in gas-fluidized beds.
Objective of project: To improve understanding and modelling of heat transfer in gas fluidized beds through the application of state-of-the-art experimental (Positron Emission Particle Tracking) and modelling (Discrete Element Method simulation) techniques.
Expected outcomes of project: New knowledge of the mechanisms of fluidized bed heat transfer. Improved the prediction of heat transfer coefficients with consequent improvements in the design and operation of fluidized bed processes.
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Synthesis of chemically well-defined and biocompatible oligopyrroles for tissue engineering applications. Modern methods of synthesis will be used to prepare chemically well-defined and structurally novel materials capable of facilitating the regeneration of damaged nerves and bone structures. This should lead to new means for treating degenerative diseases and major injuries, events that impact on hundreds of thousands of Australians each year.