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New Horizons in Diels-Alder Chemistry. Using a unique joint experimental-computational approach, we will develop reliable ways to predict the outcome of one of the most important chemical reactions. Practical applications of these new predictive tools will be developed involving powerful new versions of the reaction. Several different classes of biologically active natural products will be prepared including molecules with antitumor and antiretroviral activities. Libraries of structurally-relate ....New Horizons in Diels-Alder Chemistry. Using a unique joint experimental-computational approach, we will develop reliable ways to predict the outcome of one of the most important chemical reactions. Practical applications of these new predictive tools will be developed involving powerful new versions of the reaction. Several different classes of biologically active natural products will be prepared including molecules with antitumor and antiretroviral activities. Libraries of structurally-related analogues of natural compounds will be synthesised for biological evaluation.Read moreRead less
Experimental and Computational Investigations into Enantioselective Domino Sequences. This research program aims to develop more efficient methods for the chemical synthesis of organic substances: the materials that make up all known life forms, our medicines, and many designed materials. This research involves primarily the invention of new, enabling science. Specifically, we are trying to develop new and very general strategies to make organic compounds selectively and more efficiently than be ....Experimental and Computational Investigations into Enantioselective Domino Sequences. This research program aims to develop more efficient methods for the chemical synthesis of organic substances: the materials that make up all known life forms, our medicines, and many designed materials. This research involves primarily the invention of new, enabling science. Specifically, we are trying to develop new and very general strategies to make organic compounds selectively and more efficiently than before. A more efficient chemical synthesis means less waste, lower energy consumption and less environmental impact. Research of this kind is absolutely essential for the development of new medicines and materials. Australia lags behind many of the world's developed countries in this very important area of endeavour.Read moreRead less
Experimental-Computational Investigations into Diels-Alder Sequences. Organic molecules are an integral part of our world - in us, around us and, importantly, in our medicines. Chemists design experiments to make specific molecules by mixing the appropriate chemicals. Often, however, the outcome can't be predicted. We are developing ways to accurately predict these outcomes using computer modelling of chemical reactions. This will allow us to better understand reactions and make molecules more e ....Experimental-Computational Investigations into Diels-Alder Sequences. Organic molecules are an integral part of our world - in us, around us and, importantly, in our medicines. Chemists design experiments to make specific molecules by mixing the appropriate chemicals. Often, however, the outcome can't be predicted. We are developing ways to accurately predict these outcomes using computer modelling of chemical reactions. This will allow us to better understand reactions and make molecules more efficiently. Such research is the basis for the development of new pharmaceuticals. Few people in Australia are working in this area and we expect to train four to six people during the course of this project.Read moreRead less
The Baylis-Hillman Reaction: Asymmetric Organocatalysis and Applications. Many drugs come in two chiral mirror images (enantiomers) where the therapeutic effect is usually associated with only one while the other has no effect or can be harmful as was the case with thalidomide. Chemical reactions that yield just the desired mirror image, or enantiomer, and not the other are therefore in great demand and heavily pursued by the pharmaceutical, fine chemical and materials industries as a frontier ....The Baylis-Hillman Reaction: Asymmetric Organocatalysis and Applications. Many drugs come in two chiral mirror images (enantiomers) where the therapeutic effect is usually associated with only one while the other has no effect or can be harmful as was the case with thalidomide. Chemical reactions that yield just the desired mirror image, or enantiomer, and not the other are therefore in great demand and heavily pursued by the pharmaceutical, fine chemical and materials industries as a frontier technology. This project will result in the development of novel catalytic reactions that allow the synthesis of chiral chemicals in a cost-efficient and green manner needed by many industries, and also training of students with highly desirable synthetic skills to lead the next wave in pharmaceuticals and biotechnology.Read moreRead less
Discovering new organic chemistry using an inorganic touch. This project aims to discover new organic chemistry by treating carbon like a metal atom. Advances in fundamental organic chemistry have been important in developing products, including medicines, plastics and television display technology. Much research activity relies on applying existing organic chemistry, but inventing genuinely new organic chemistry is more difficult. By viewing carbon as a metal, this project will try to solve imp ....Discovering new organic chemistry using an inorganic touch. This project aims to discover new organic chemistry by treating carbon like a metal atom. Advances in fundamental organic chemistry have been important in developing products, including medicines, plastics and television display technology. Much research activity relies on applying existing organic chemistry, but inventing genuinely new organic chemistry is more difficult. By viewing carbon as a metal, this project will try to solve important problems in organic chemistry that have been unresolved for decades, and synthesise valuable chemicals normally generated using expensive precious metal catalysts.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561203
Funder
Australian Research Council
Funding Amount
$110,000.00
Summary
Microwave Assisted Chemistry - new approaches to molecular diversity. This project will support the establishment of a multi-user, fully automated microwave reactor facility that will be the first of its kind in an academic laboratory in Australia. The equipment will support a wide range of synthetic chemistry research by providing microwave acceleration to otherwise slow reactions and in some cases promotion of reactions that do not normally proceed under conventional conditions. The automation ....Microwave Assisted Chemistry - new approaches to molecular diversity. This project will support the establishment of a multi-user, fully automated microwave reactor facility that will be the first of its kind in an academic laboratory in Australia. The equipment will support a wide range of synthetic chemistry research by providing microwave acceleration to otherwise slow reactions and in some cases promotion of reactions that do not normally proceed under conventional conditions. The automation capability will be used to create diverse compound libraries and to investigate and optimise reaction conditions.Read moreRead less
New synthetic strategies to small cyclic peptides. This project aims to invent new synthetic strategies that enable chemical manipulation of small cyclic peptides, a promising class of biologically active molecules with high metabolic stability. Combining theory and practice, this project will develop novel acyl transfer reactions that will allow traceless, site-selective, ring expansion and contraction of small cyclic peptides. This project will result in new synthetic methodology that will sim ....New synthetic strategies to small cyclic peptides. This project aims to invent new synthetic strategies that enable chemical manipulation of small cyclic peptides, a promising class of biologically active molecules with high metabolic stability. Combining theory and practice, this project will develop novel acyl transfer reactions that will allow traceless, site-selective, ring expansion and contraction of small cyclic peptides. This project will result in new synthetic methodology that will simplify the synthesis of an important class of small drug-like molecules. This will provide significant benefits, such as a breakthrough in the synthetic approach to small cyclic peptides, which will strengthen Australia’s international standing in peptide research and provide new strategies for translation to the growing biotechnology industry.Read moreRead less
A blueprint for cross-conjugation and a gateway for new directions in synthesis. This research program aims to develop better ways to make and understand organic substances: the materials that make up all known life forms, our medicines, and many designed materials. A better understanding of organic structure and reactivity leads to better medicines, smarter materials, and less environmental impact from chemical processes.
Next Generation Synthesis. The ambitious aim of this work is to re-define the limits of what is possible in reactions and structure in organic chemistry. This research aims to push the science of synthesis beyond current levels of sophistication in both the types of structures that will be prepared and the methods that will be used preparing them. One section of this work focuses on the preparation of fundamental classes of organic compounds that have not yet succumbed to synthesis. Another invo ....Next Generation Synthesis. The ambitious aim of this work is to re-define the limits of what is possible in reactions and structure in organic chemistry. This research aims to push the science of synthesis beyond current levels of sophistication in both the types of structures that will be prepared and the methods that will be used preparing them. One section of this work focuses on the preparation of fundamental classes of organic compounds that have not yet succumbed to synthesis. Another involves the development of chemical syntheses that reach levels of efficiency beyond those in current use. Put simply, the goal of this work is to stretch the boundaries, both in terms of chemical structure and in terms of step-efficiency in chemical synthesis. Read moreRead less
Getting the reaction outcomes you want: towards solvent-controlled reactivity using ionic liquids. Ionic liquids can replace existing reaction solvents, which may be volatile, flammable and toxic. However, the effect on the reaction outcome of such a replacement is poorly understood. This project aims to identify cases where ionic liquids will benefit a reaction, resulting in the development of improved processes.