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New Horizons in Diels-Alder Chemistry. Using a unique joint experimental-computational approach, we will develop reliable ways to predict the outcome of one of the most important chemical reactions. Practical applications of these new predictive tools will be developed involving powerful new versions of the reaction. Several different classes of biologically active natural products will be prepared including molecules with antitumor and antiretroviral activities. Libraries of structurally-relate ....New Horizons in Diels-Alder Chemistry. Using a unique joint experimental-computational approach, we will develop reliable ways to predict the outcome of one of the most important chemical reactions. Practical applications of these new predictive tools will be developed involving powerful new versions of the reaction. Several different classes of biologically active natural products will be prepared including molecules with antitumor and antiretroviral activities. Libraries of structurally-related analogues of natural compounds will be synthesised for biological evaluation.Read moreRead less
Experimental and Computational Investigations into Enantioselective Domino Sequences. This research program aims to develop more efficient methods for the chemical synthesis of organic substances: the materials that make up all known life forms, our medicines, and many designed materials. This research involves primarily the invention of new, enabling science. Specifically, we are trying to develop new and very general strategies to make organic compounds selectively and more efficiently than be ....Experimental and Computational Investigations into Enantioselective Domino Sequences. This research program aims to develop more efficient methods for the chemical synthesis of organic substances: the materials that make up all known life forms, our medicines, and many designed materials. This research involves primarily the invention of new, enabling science. Specifically, we are trying to develop new and very general strategies to make organic compounds selectively and more efficiently than before. A more efficient chemical synthesis means less waste, lower energy consumption and less environmental impact. Research of this kind is absolutely essential for the development of new medicines and materials. Australia lags behind many of the world's developed countries in this very important area of endeavour.Read moreRead less
Experimental-Computational Investigations into Diels-Alder Sequences. Organic molecules are an integral part of our world - in us, around us and, importantly, in our medicines. Chemists design experiments to make specific molecules by mixing the appropriate chemicals. Often, however, the outcome can't be predicted. We are developing ways to accurately predict these outcomes using computer modelling of chemical reactions. This will allow us to better understand reactions and make molecules more e ....Experimental-Computational Investigations into Diels-Alder Sequences. Organic molecules are an integral part of our world - in us, around us and, importantly, in our medicines. Chemists design experiments to make specific molecules by mixing the appropriate chemicals. Often, however, the outcome can't be predicted. We are developing ways to accurately predict these outcomes using computer modelling of chemical reactions. This will allow us to better understand reactions and make molecules more efficiently. Such research is the basis for the development of new pharmaceuticals. Few people in Australia are working in this area and we expect to train four to six people during the course of this project.Read moreRead less
New Horizons in Quinonedimethide Chemistry. Quinonedimethides (QDMs) are organic molecules with a notorious reputation for instability, hence they are poorly understood and an underexploited resource. This project will unite the ideally suited computational and experimental skills of the CIs to perform the first thorough investigation into fundamental QDM chemistry. It aims to map structure-reactivity in QDMs, investigate their ability to rapidly generate complex structures, and demonstrate thei ....New Horizons in Quinonedimethide Chemistry. Quinonedimethides (QDMs) are organic molecules with a notorious reputation for instability, hence they are poorly understood and an underexploited resource. This project will unite the ideally suited computational and experimental skills of the CIs to perform the first thorough investigation into fundamental QDM chemistry. It aims to map structure-reactivity in QDMs, investigate their ability to rapidly generate complex structures, and demonstrate their potential in spintronics and other applications. Anticipated outcomes include powerful and general new synthetic concepts, methods, strategies and tactics. This should provide significant benefits, such as better ways to manufacture important medicines and other materials.Read moreRead less
A blueprint for cross-conjugation and a gateway for new directions in synthesis. This research program aims to develop better ways to make and understand organic substances: the materials that make up all known life forms, our medicines, and many designed materials. A better understanding of organic structure and reactivity leads to better medicines, smarter materials, and less environmental impact from chemical processes.
Next Generation Synthesis. The ambitious aim of this work is to re-define the limits of what is possible in reactions and structure in organic chemistry. This research aims to push the science of synthesis beyond current levels of sophistication in both the types of structures that will be prepared and the methods that will be used preparing them. One section of this work focuses on the preparation of fundamental classes of organic compounds that have not yet succumbed to synthesis. Another invo ....Next Generation Synthesis. The ambitious aim of this work is to re-define the limits of what is possible in reactions and structure in organic chemistry. This research aims to push the science of synthesis beyond current levels of sophistication in both the types of structures that will be prepared and the methods that will be used preparing them. One section of this work focuses on the preparation of fundamental classes of organic compounds that have not yet succumbed to synthesis. Another involves the development of chemical syntheses that reach levels of efficiency beyond those in current use. Put simply, the goal of this work is to stretch the boundaries, both in terms of chemical structure and in terms of step-efficiency in chemical synthesis. Read moreRead less
Platform Technologies for the Regulation of Peptide Hormones. Research in the field of this application is expected to contribute to the social and economic welfare of Australians. It is anticipated that a platform of technologies will be developed, for the treatment of human and animal disorders associated with imbalances in levels of peptide hormones. This will provide better therapies to improve human and animal health. Related potential applications include the development of more effective ....Platform Technologies for the Regulation of Peptide Hormones. Research in the field of this application is expected to contribute to the social and economic welfare of Australians. It is anticipated that a platform of technologies will be developed, for the treatment of human and animal disorders associated with imbalances in levels of peptide hormones. This will provide better therapies to improve human and animal health. Related potential applications include the development of more effective insecticides. The range of new materials and protocols that will result from the research will be suitable for commercial exploitation. Particular benefit to Australians will result from the research being carried out locally, where the intellectual property and expertise will be developed and maintained.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100065
Funder
Australian Research Council
Funding Amount
$423,808.00
Summary
Designing Organocatalysts to Achieve Hyperpolarised Magnetic Resonance. Magnetic resonance techniques (such as MRI scans) suffer from an inherent insensitivity problem. In medical imaging, this can hamper diagnosis and mean long scan times for patients. This project aims to chemically develop catalysts which dramatically increase sensitivity, producing a signal that is thousands of times more visible. This project is significant as these catalysts can turn common, harmless molecules in the body ....Designing Organocatalysts to Achieve Hyperpolarised Magnetic Resonance. Magnetic resonance techniques (such as MRI scans) suffer from an inherent insensitivity problem. In medical imaging, this can hamper diagnosis and mean long scan times for patients. This project aims to chemically develop catalysts which dramatically increase sensitivity, producing a signal that is thousands of times more visible. This project is significant as these catalysts can turn common, harmless molecules in the body - even water - into visible tracers. The expected outcomes of this project include the synthesis and understanding of these catalysts which will be chemically fine-tuned to maximise their effectiveness. Potential benefits include translation to MRI applications to improve diagnosis and treatment, or chemical monitoring.Read moreRead less
gem-Dihalogenocyclopropanes as building blocks for the chemical synthesis of biologically active natural products and their analogues. New and efficient methods for the assembly of biologically active compounds will emerge from this research and thus provide materials for evaluation as potential therapeutics in the treatment of a range of pathological conditions including Alzheimer's disease and certain types of lung cancers that respond poorly to currently available treatments. The underpinning ....gem-Dihalogenocyclopropanes as building blocks for the chemical synthesis of biologically active natural products and their analogues. New and efficient methods for the assembly of biologically active compounds will emerge from this research and thus provide materials for evaluation as potential therapeutics in the treatment of a range of pathological conditions including Alzheimer's disease and certain types of lung cancers that respond poorly to currently available treatments. The underpinning methodologies are also likely to provide opportunities in other areas, including materials science. The training of a highly capable post-doctoral in chemical synthesis, an area where there is now an extraordinary and unsatisfied demand for such expertise, will be a further benefit of the proposed program of research.Read moreRead less