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Synthesis of Novel Dual Acting, Selenium Containing Antioxidants. Ischemic heart disease and chronic inflammation afflict a large segment of the Australian population, especially the ageing. These states are associated with free-radicals and other reactive oxygen species and can be controlled to some extent by the application of adenosine therapy. This project will combine the activity of adenosine agonists and enhancers with selenium-containing antioxidants, used to quench reactive oxygen spe ....Synthesis of Novel Dual Acting, Selenium Containing Antioxidants. Ischemic heart disease and chronic inflammation afflict a large segment of the Australian population, especially the ageing. These states are associated with free-radicals and other reactive oxygen species and can be controlled to some extent by the application of adenosine therapy. This project will combine the activity of adenosine agonists and enhancers with selenium-containing antioxidants, used to quench reactive oxygen species, to provide a powerful new class of pharmaceutical products designed to enhance the quality of life of Australians afflicted by diseases propagated by free-radicals.Read moreRead less
Generation of peptidomimetic surfaces for biomaterials applications. Biomedical implants are increasingly being used for the treatment of a variety of ailments. This project will significantly contribute to the development of these bioengineered constructs, by introducing an innovative method for tailoring the nature of the surface of these materials with structures that mimic the response of biological surfaces. This technology has the potential to promote favourable interactions of cells with ....Generation of peptidomimetic surfaces for biomaterials applications. Biomedical implants are increasingly being used for the treatment of a variety of ailments. This project will significantly contribute to the development of these bioengineered constructs, by introducing an innovative method for tailoring the nature of the surface of these materials with structures that mimic the response of biological surfaces. This technology has the potential to promote favourable interactions of cells with biomedical implants, and an initial targeted application will be to use these bioengineered constructs in the treatment of preventable blindness and severe visual impairment, afflictions which affect over 180 million individuals worldwide.Read moreRead less
Design and synthesis of novel lanthanoid complexes for the fabrication of light emitting devices. There is a huge and still growing economy centred around the design and fabrication of low-cost Light Emitting Devices (LEDs), as demonstrated by the excess of US$1.3 billion invested in this field between 2000 and 2007. Nations focused on the production of new and more efficient materials will be at the forefront of these emerging technologies. The major thrust of this proposal, the design and prep ....Design and synthesis of novel lanthanoid complexes for the fabrication of light emitting devices. There is a huge and still growing economy centred around the design and fabrication of low-cost Light Emitting Devices (LEDs), as demonstrated by the excess of US$1.3 billion invested in this field between 2000 and 2007. Nations focused on the production of new and more efficient materials will be at the forefront of these emerging technologies. The major thrust of this proposal, the design and preparation of luminescent rare earths complexes, and their use for the fabrication of LEDS, represent a good opportunity for Australia to access this growing market. Read moreRead less
Fluorine-labelled proteins for NMR spectroscopy. The technique developed in this project has direct impact on pharmaceutical research: NMR spectroscopy is used routinely to identify chemical compounds that bind to protein targets. This project includes the development of novel assignment techniques of 19F-labelled proteins, so that 19F-NMR can be used to detect specific binding interactions. One of the methods proposed here is designed to reveal structural information about the binding mode in s ....Fluorine-labelled proteins for NMR spectroscopy. The technique developed in this project has direct impact on pharmaceutical research: NMR spectroscopy is used routinely to identify chemical compounds that bind to protein targets. This project includes the development of novel assignment techniques of 19F-labelled proteins, so that 19F-NMR can be used to detect specific binding interactions. One of the methods proposed here is designed to reveal structural information about the binding mode in solution with atomic detail. This knowledge can significantly accelerate drug development. It is otherwise only available from crystal structures that can not always be determined.Read moreRead less
Improving explosive emulsions by understanding surfactant interactions. This project will design new surfactants that will lead to more cost effective, stable and reliable explosive emulsions. The pressure required to force dispersed phase droplets to coalesce will be measured both directly and by osmotic stress. These parameters have not previously been measured for an inverse emulsion system. The measurements made will be correlated to the structure of the stabilising surfactant enabling new a ....Improving explosive emulsions by understanding surfactant interactions. This project will design new surfactants that will lead to more cost effective, stable and reliable explosive emulsions. The pressure required to force dispersed phase droplets to coalesce will be measured both directly and by osmotic stress. These parameters have not previously been measured for an inverse emulsion system. The measurements made will be correlated to the structure of the stabilising surfactant enabling new and more effective surfactants to be designed.Read moreRead less
Biodegradable Porous HEMA-Based Polymers: Innovative Strategies for the Design and Tuneable Single-Step Production of a Novel Class of Scaffolds for Tissue Engineering. This project will lead to the development of new biocompatible, biodegradable, porous materials ideally suited to many applications in tissue engineering. These new biomaterials will be relatively inexpensive to manufacture, via simple processes using non-toxic reagents. The key properties of the biomaterials will be controllable ....Biodegradable Porous HEMA-Based Polymers: Innovative Strategies for the Design and Tuneable Single-Step Production of a Novel Class of Scaffolds for Tissue Engineering. This project will lead to the development of new biocompatible, biodegradable, porous materials ideally suited to many applications in tissue engineering. These new biomaterials will be relatively inexpensive to manufacture, via simple processes using non-toxic reagents. The key properties of the biomaterials will be controllable by appropriate choice of starting materials. The availability of these new biomaterials will facilitate future developments in tissue engineering, which will ultimately lead to improved medical outcomes in areas as diverse as joint and bone repair and organ regeneration. Local manufacture of these biomaterials would also contribute to the development of the Australian biotechnology industry.Read moreRead less
Modern Low Oxidation State/Low Coordination Main Group Chemistry: A New Domain for Australian Science. The proposed research will benefit Australia by creating a knowledge base in an internationally important area of chemistry. This will be aided by the return to Australia of an international leader in the field. Through an integrated and interdisciplinary approach, the exploitation of technologies arising from the research program will be explored. In addition to the academic community, these ....Modern Low Oxidation State/Low Coordination Main Group Chemistry: A New Domain for Australian Science. The proposed research will benefit Australia by creating a knowledge base in an internationally important area of chemistry. This will be aided by the return to Australia of an international leader in the field. Through an integrated and interdisciplinary approach, the exploitation of technologies arising from the research program will be explored. In addition to the academic community, these technologies will benefit hi-tech industries including pharmaceutical and fine chemicals concerns which will gain from the use of the proposed group 13 heterocycles in organic synthesis. Moreover, industries reliant on polymer supports in catalytic process or opto-electronic polymers will profit from the various polymers derived from phosphaalkynes.Read moreRead less
Extraction of gold from thiosulfate leach liquors using selective magnetic ion exchange (MIEX) resins. Cyanide processes used for gold leaching can cause severe environmental problems. This proposal studies the use of thiosulfate as an alternative, concentrating on the design and synthesis of new functionalised magnetic ion-exchange resins, which will act as selective adsorbents for the gold thiosulfate complex and thereby facilitate the implementation of this efficient, low environmental impact ....Extraction of gold from thiosulfate leach liquors using selective magnetic ion exchange (MIEX) resins. Cyanide processes used for gold leaching can cause severe environmental problems. This proposal studies the use of thiosulfate as an alternative, concentrating on the design and synthesis of new functionalised magnetic ion-exchange resins, which will act as selective adsorbents for the gold thiosulfate complex and thereby facilitate the implementation of this efficient, low environmental impact process. Since the leaching is typically applied to ores rich in copper, resins for the recovery of copper will also be designed. Laboratory proving trials will be conducted and successful candidates will be considered for future commercialisation of a Resin-in-Pulp leaching and recovery process.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0237384
Funder
Australian Research Council
Funding Amount
$156,000.00
Summary
Raman Spectroscopy Mapping Facility. This proposal seeks to provide a confocal Raman spectrometer for researchers at the Universities of Wollongong, Western Sydney, Newcastle and University of Technology, Sydney. The Facility will have the exceptional capability of characterising and mapping, at the micron level, the chemical nature of a wide range of advanced materials under development in our laboratories. The information derived will be of critical value for potential applications such as new ....Raman Spectroscopy Mapping Facility. This proposal seeks to provide a confocal Raman spectrometer for researchers at the Universities of Wollongong, Western Sydney, Newcastle and University of Technology, Sydney. The Facility will have the exceptional capability of characterising and mapping, at the micron level, the chemical nature of a wide range of advanced materials under development in our laboratories. The information derived will be of critical value for potential applications such as new corrosion-protection coatings, highly selective chemical and biochemical sensors, and new solar energy materials. The Facility will also be invaluable for the quantitative characterisation of forensic and geological samples that are otherwise difficult to identify due to their heterogeneous nature.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560679
Funder
Australian Research Council
Funding Amount
$932,870.00
Summary
Materials and Surface Characterisation Facility. Australian scientists are well positioned to be at the forefront of nanotechnology, biotechnology and advanced materials development. The proposed Facility, housing state-of-the-art equipment, will enable cutting-edge research in these areas by internationally renowned researchers at the University of Melbourne, Monash University, RMIT University, and CSIRO. Such research will facilitate the development of advanced materials for diverse applicatio ....Materials and Surface Characterisation Facility. Australian scientists are well positioned to be at the forefront of nanotechnology, biotechnology and advanced materials development. The proposed Facility, housing state-of-the-art equipment, will enable cutting-edge research in these areas by internationally renowned researchers at the University of Melbourne, Monash University, RMIT University, and CSIRO. Such research will facilitate the development of advanced materials for diverse applications including drug delivery, quantum computing, photonics and tissue engineering. The multi-user Facility will enable closer collaboration with researchers in academia and industry, and will be integral in training the next generation of Australian scientists in the nano- and biosciences.Read moreRead less