Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100127
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Flow Reactor Chemical Synthesis Facility. Flow reactor chemical synthesis facility: This flow chemistry facility aims to greatly expand upon the traditional scale batch synthesis operations that are currently in use by organic, organometallic, biological and materials chemistry researchers while minimising environmental impact. The anticipated advantages of this facility are manifold and include both significantly enhanced capabilities (broader experimental/chemical space) and considerably impro ....Flow Reactor Chemical Synthesis Facility. Flow reactor chemical synthesis facility: This flow chemistry facility aims to greatly expand upon the traditional scale batch synthesis operations that are currently in use by organic, organometallic, biological and materials chemistry researchers while minimising environmental impact. The anticipated advantages of this facility are manifold and include both significantly enhanced capabilities (broader experimental/chemical space) and considerably improved safety and efficiency (no unstable intermediate accumulation, greater selectivity, cleaner products, reduced solvent requirements).Read moreRead less
New vistas in porphyrin chemistry via metal-catalyzed couplings with hydrazine derivatives. This project will address basic scientific questions and develop new substances for use in molecular electronics and cancer therapy. We will make and study entirely new molecules derived from porphyrins, which in Nature have vital roles in photosynthesis, oxygen transport and enzyme catalysis. This breakthrough research will reveal knowledge vital to the advancement of fundamental chemical science and als ....New vistas in porphyrin chemistry via metal-catalyzed couplings with hydrazine derivatives. This project will address basic scientific questions and develop new substances for use in molecular electronics and cancer therapy. We will make and study entirely new molecules derived from porphyrins, which in Nature have vital roles in photosynthesis, oxygen transport and enzyme catalysis. This breakthrough research will reveal knowledge vital to the advancement of fundamental chemical science and also offer excellent training in cutting edge research for young Australian scientists. In addition, porphyrin-like substances are used in cancer diagnosis and treatment and have properties essential for the next generation of nanoelectronic devices, and this project is aimed at these eventual outcomes.Read moreRead less
Utilising nature's complexity - understanding fundamental organometallic binding modes of furans and coordination of bioderived furans. The earth's decreasing reserves of fossil fuels has prompted an intense push to utilise the renewable bioresources to replace the many products and fuels derived from petroleum. One of the promising developments is the production of so-called Furanics, useful molecules produced easily from carbohydrates found in waste materials from the sugar, corn and forestry ....Utilising nature's complexity - understanding fundamental organometallic binding modes of furans and coordination of bioderived furans. The earth's decreasing reserves of fossil fuels has prompted an intense push to utilise the renewable bioresources to replace the many products and fuels derived from petroleum. One of the promising developments is the production of so-called Furanics, useful molecules produced easily from carbohydrates found in waste materials from the sugar, corn and forestry industries. Given Australia's wealth of agricultural resources, discovering the full power of these potentially useful furanic compounds should be a major priority. This research aims to link Australia's biomass potential with the plastics, pharmaceutical, fine and agrichemical industries.Read moreRead less
Coinage metal nanoclusters: synthesis, structure and reactivity. Metal catalysts play important roles in the multi-billion dollar production of many industrial and fine chemicals used in wide-ranging applications including pharmaceuticals, insecticides and polymers. Despite the importance of metal catalysed reactions, the molecular details of such processes remain poorly understood. Breakthrough studies highlight that reactions previously thought to be catalysed by discrete metal catalysts are i ....Coinage metal nanoclusters: synthesis, structure and reactivity. Metal catalysts play important roles in the multi-billion dollar production of many industrial and fine chemicals used in wide-ranging applications including pharmaceuticals, insecticides and polymers. Despite the importance of metal catalysed reactions, the molecular details of such processes remain poorly understood. Breakthrough studies highlight that reactions previously thought to be catalysed by discrete metal catalysts are in fact catalysed by metal nanoclusters. This project involves the application of advanced mass spectrometric and computational methods to explore the formation and reactivity of copper, silver and gold nanoclusters. Identification of key reactive intermediates will inform the design of next generation catalysts.Read moreRead less
Organometallic Transformations of Organic Compounds. The program will develop new metal-based catalysts for two main purposes (i) transforming basic hydrocarbons eg. natural gas and low-molecular-weight petroleum products into more advanced compounds (such as alcohols, alkenes and carboxylic acids); and (ii) converting nitrogen gas into nitrogen-containing compounds eg. ammonia or ammonia derivatives. In both projects, the aim is to take readily available and abundant starting materials that ar ....Organometallic Transformations of Organic Compounds. The program will develop new metal-based catalysts for two main purposes (i) transforming basic hydrocarbons eg. natural gas and low-molecular-weight petroleum products into more advanced compounds (such as alcohols, alkenes and carboxylic acids); and (ii) converting nitrogen gas into nitrogen-containing compounds eg. ammonia or ammonia derivatives. In both projects, the aim is to take readily available and abundant starting materials that are currently difficult to utilise and to design and develop specific reagents to convert them to "value-added" products. The program will also explore the mode of action of metal-based reagents leading to better reagent and catalyst design.Read moreRead less
Synthesis of new heterocyclic analogues of isoflavones. Intake of high dietary isoflavonoid phytoestrogens has been linked to low prevalence of hormone-dependent cancers such as breast and prostate cancer, and heart disease. The isoflavones resemble endogenous estradiol in structure, and have been shown to display weak estrogenic activity. Novogen Limited is pioneering the development of novel drug candidates based on isoflavones. This collaborative research project deals with the development o ....Synthesis of new heterocyclic analogues of isoflavones. Intake of high dietary isoflavonoid phytoestrogens has been linked to low prevalence of hormone-dependent cancers such as breast and prostate cancer, and heart disease. The isoflavones resemble endogenous estradiol in structure, and have been shown to display weak estrogenic activity. Novogen Limited is pioneering the development of novel drug candidates based on isoflavones. This collaborative research project deals with the development of synthetic methodologies for the preparation of new analogues of isoflavone metabolites as potential drug candidates. The target compounds will be evaluated for possible therapeutic use by the industry partner.Read moreRead less
Synthesis of pyrroloquinoline analogues of isoflavone metabolites. Cancer and heart disease are the two main diseases that affect our society indiscriminately and put enormous drains on healthcare resources. The intake of high dietary isoflavonoid phytoestrogens has been linked to low prevalence of cancers and heart disease. Novogen Limited is pioneering the development of novel drug candidates based on phytoestrogen metabolites. This collaborative research project deals with the development ....Synthesis of pyrroloquinoline analogues of isoflavone metabolites. Cancer and heart disease are the two main diseases that affect our society indiscriminately and put enormous drains on healthcare resources. The intake of high dietary isoflavonoid phytoestrogens has been linked to low prevalence of cancers and heart disease. Novogen Limited is pioneering the development of novel drug candidates based on phytoestrogen metabolites. This collaborative research project deals with the development of synthetic methodologies for the preparation of new analogues of phytoestrogen metabolites as potential drug candidates. The target compounds will be evaluated for possible therapeutic use by the industry partner.Read moreRead less
New Catalysed Routes to the Efficient Synthesis of Biologically Active Molecules. Enhancing the economic viability and the energy efficiency of chemical transformations is of fundamental importance in the chemicals industry, and is essential in the targeted production of drugs and fine chemicals for frontier technologies. By using multiple metal centres to simultaneously promote series of reaction steps in a single pot, this project will develop an innovative approach to efficient syntheses of b ....New Catalysed Routes to the Efficient Synthesis of Biologically Active Molecules. Enhancing the economic viability and the energy efficiency of chemical transformations is of fundamental importance in the chemicals industry, and is essential in the targeted production of drugs and fine chemicals for frontier technologies. By using multiple metal centres to simultaneously promote series of reaction steps in a single pot, this project will develop an innovative approach to efficient syntheses of biologically active molecules. The new methods and new catalysts for enhancing the synthesis of highly functionalised compounds will improve significantly the environmental impact of chemical processes by reducing the amount of chemicals required, and reducing waste and energy requirements.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100213
Funder
Australian Research Council
Funding Amount
$840,000.00
Summary
Multinuclear 700 MHz Nuclear Magnetic Resonance (NMR) spectrometer for advanced molecular analysis. Nuclear Magnetic Resonance (NMR) spectroscopy is the most important analytical tool in chemistry. A new 700 MHz NMR spectrometer is to replace three outdated NMR spectrometers at the NMR Facility to enable new multinuclear experiments, while serving the analytical needs of over 20 research groups in chemical and biological research.
Advancing the Metal-Organic Chemistry of the Heavy Alkaline Earth Elements. The project will open up a new area in Australian metal based chemical research, deriving high value added products from the already existing exploitation of Australia's substantial alkaline earth metal mineral resources. Internationally recognised expertise in the design and manipulation of highly reactive chemical tools will contribute breakthrough science and innovation to the growing pharmaceutical, fine chemicals an ....Advancing the Metal-Organic Chemistry of the Heavy Alkaline Earth Elements. The project will open up a new area in Australian metal based chemical research, deriving high value added products from the already existing exploitation of Australia's substantial alkaline earth metal mineral resources. Internationally recognised expertise in the design and manipulation of highly reactive chemical tools will contribute breakthrough science and innovation to the growing pharmaceutical, fine chemicals and smart materials industry, with the potential to provide nascent and established Australian companies a competitive edge in new product development. Students will be trained in the necessary skills to succeed in and expand such technically demanding area of metal based chemistry.Read moreRead less