The Australian historic shipwreck protection project: the in situ preservation and reburial of a colonial trader - Clarence (1850). The project will use cutting-edge technology to study and preserve an early colonial shipwreck at risk and develop a world-class strategy for the reburial and preservation of endangered historic shipwrecks. The project will help develop new national policy and technical guidelines for site managers of historic shipwrecks and offer new insights into colonial shipbuil ....The Australian historic shipwreck protection project: the in situ preservation and reburial of a colonial trader - Clarence (1850). The project will use cutting-edge technology to study and preserve an early colonial shipwreck at risk and develop a world-class strategy for the reburial and preservation of endangered historic shipwrecks. The project will help develop new national policy and technical guidelines for site managers of historic shipwrecks and offer new insights into colonial shipbuilding.Read moreRead less
Geochemistry of ore metals at very high temperatures. The world’s largest copper and gold mines occur in extinct volcanoes around the Pacific Rim. Understanding how these essential metals are mobilised from magmas in the roots of volcanoes to become ore deposits and how to recognize where this has occurred is crucial in exploration for new deposits.
Hydrothermal remobilisation of base metals and platinum group elements in magmatic nickel deposits. Magmatic nickel sulphide deposits are highly valuable but extremely challenging exploration targets, thought to lack the distinctive geochemical haloes that allow small targets to be identified from sparse drilling. The project will test the potential of hydrothermal remobilisation of nickel, cobalt and platinum group elements to create broad alteration haloes.
Ore deposits and tectonic evolution of the Lachlan Orogen, SE Australia. Ore deposits and tectonic evolution of the Lachlan Orogen, SE Australia. This project aims to develop and test models to evaluate past tectonic processes and configurations in South-east Australia, using both new and existing geological, geophysical and isotopic data. Over the past 550 million years, plate tectonic processes have formed metal-rich mineral deposits in South-east Australia. The project will identify areas of ....Ore deposits and tectonic evolution of the Lachlan Orogen, SE Australia. Ore deposits and tectonic evolution of the Lachlan Orogen, SE Australia. This project aims to develop and test models to evaluate past tectonic processes and configurations in South-east Australia, using both new and existing geological, geophysical and isotopic data. Over the past 550 million years, plate tectonic processes have formed metal-rich mineral deposits in South-east Australia. The project will identify areas of high potential for economically valuable ore deposits, enabling more efficient prioritisation of mineral exploration efforts. This is expected to increase the probability of significant ore deposit discoveries leading to national economic benefit.Read moreRead less
Synthesis of chemically well-defined and biocompatible oligopyrroles for tissue engineering applications. Modern methods of synthesis will be used to prepare chemically well-defined and structurally novel materials capable of facilitating the regeneration of damaged nerves and bone structures. This should lead to new means for treating degenerative diseases and major injuries, events that impact on hundreds of thousands of Australians each year.
Synthetic compounds to specifically activate or inhibit ryanodine receptor calcium ion channels. The aim of the project is develop synthetic compounds that specifically and reversibly activate or inhibit ryanodine receptor calcium release channels, and will thus increase or reduce the force developed by skeletal muscle and the heart. The compounds will be useful in biomedical and veterinary sciences and in the livestock industry. Some of the compounds that are not effective on mammalian ryan ....Synthetic compounds to specifically activate or inhibit ryanodine receptor calcium ion channels. The aim of the project is develop synthetic compounds that specifically and reversibly activate or inhibit ryanodine receptor calcium release channels, and will thus increase or reduce the force developed by skeletal muscle and the heart. The compounds will be useful in biomedical and veterinary sciences and in the livestock industry. Some of the compounds that are not effective on mammalian ryandine receptor isoforms might interact with insect channels and provide a template for a new class of insecticides. The compounds will be based on naturally occurring peptides which specifically and reversibly modulate mammalian calcium channels.Read moreRead less
Strategies for the detection of designer steroids in greyhounds. Strategies for the detection of designer steroids in greyhounds. This project aims to develop strategies to detect designer steroids in racing greyhounds to safeguard industry integrity and animal welfare. These strategies include in vivo and comparative in vitro studies of steroid metabolism, mass-spectrometric elucidation of metabolite structures, and synthesis of putative steroid metabolites with different stereochemistries and ....Strategies for the detection of designer steroids in greyhounds. Strategies for the detection of designer steroids in greyhounds. This project aims to develop strategies to detect designer steroids in racing greyhounds to safeguard industry integrity and animal welfare. These strategies include in vivo and comparative in vitro studies of steroid metabolism, mass-spectrometric elucidation of metabolite structures, and synthesis of putative steroid metabolites with different stereochemistries and oxidation patterns as reference materials. This project will use major metabolites identified by these studies to develop analytical procedures to test for drug abuse at greyhound race meetings. The project will target twelve readily available designer steroid supplements that have significant risk of abuse.Read moreRead less
Synthesis and Analysis of Canine Anabolic Steroid Metabolites. The Australian racing industry is a major driver of economic activity. In NSW, racing is estimated to contribute $1,000 million to GDP, $151 million to Government revenue and provide 50,000 jobs. The future security and prosperity of the racing industry depends on maintaining the highest standards of integrity in the public eye, and this in turn depends on the enforcement of regulations relating to illicit substances. The outcome of ....Synthesis and Analysis of Canine Anabolic Steroid Metabolites. The Australian racing industry is a major driver of economic activity. In NSW, racing is estimated to contribute $1,000 million to GDP, $151 million to Government revenue and provide 50,000 jobs. The future security and prosperity of the racing industry depends on maintaining the highest standards of integrity in the public eye, and this in turn depends on the enforcement of regulations relating to illicit substances. The outcome of this project will be the introduction of robust methods of analysis for potential drug abuse in greyhound racing that will position Australia as a world leader in the field.Read moreRead less
Marine Natural Products as Sources of Agrochemicals - The Variolins. The aim of this project is the identification of new classes of agrochemicals with better pest resistance and environmental profiles. The proposed partnership with a major international chemical manufacturing organization will allow access to state-of-the-art techniques for the screening and development of novel compounds as agents for the control of pests that affect many major agricultural crops relevant to Australia's econo ....Marine Natural Products as Sources of Agrochemicals - The Variolins. The aim of this project is the identification of new classes of agrochemicals with better pest resistance and environmental profiles. The proposed partnership with a major international chemical manufacturing organization will allow access to state-of-the-art techniques for the screening and development of novel compounds as agents for the control of pests that affect many major agricultural crops relevant to Australia's economy. Australian graduate students will experience the operations of one of the world's biggest chemical manufacturers. The derivation of agrochemicals from marine sources will promote further recognition of the value of marine ecosystems around Australia.Read moreRead less
Development of Chemoenzymatic Methods for the Selective Elaboration of Polyfunctionalised Therapeutic Agents to Oligomers with Improved Efficacy. The aims of the project are to screen a novel collection of genetically engineered enzymes for their capacity to selectively manipulate proven therapeutic agents so that, ultimately, much more potent polymeric derivatives of the agent/drug can be obtained. The combined use of enzyme libraries and chemical manipulations to generate more powerful polymer ....Development of Chemoenzymatic Methods for the Selective Elaboration of Polyfunctionalised Therapeutic Agents to Oligomers with Improved Efficacy. The aims of the project are to screen a novel collection of genetically engineered enzymes for their capacity to selectively manipulate proven therapeutic agents so that, ultimately, much more potent polymeric derivatives of the agent/drug can be obtained. The combined use of enzyme libraries and chemical manipulations to generate more powerful polymeric variants of already established drugs has never been undertaken previously in Australia. This approach has the capacity to generate hitherto inaccessible classes of therapeutic entities and to provide a new and unique technology platform for the country's biotechnology industry.Read moreRead less