Appropriate growth of organs is essential for life and can go awry in diseases such as cancer. A crucial regulator of organ size and cancer that I co-discovered is the Hippo pathway. I aim to understand how this pathway relays information and controls gene expression to regulate organ size, and its role in mesothelioma and other human cancers. A better understanding of Hippo’s role in organ growth and cancer will allow it to be targeted for therapeutic benefit in human diseases.
Bridging The Gap: Using Data Science To Transform Care And Health Outcomes In Kidney Transplant Recipients
Funder
National Health and Medical Research Council
Funding Amount
$1,155,135.00
Summary
Despite substantive survival and quality of life benefits compared to being on dialysis, kidney transplant recipients suffer from premature death, largely due to complications such as cancer and cardiovascular. Using big data science, we will be able to predict these complications in the context of chronic immunosuppression, find new and better ways to identify at risk individuals, to deliver effective and efficient screening and treatment strategies in this vulnerable population.