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Bisphosphonate Use, Oral Flora, Saliva, Gingival Crevicular Fluid And Bone Markers In Patients With Jaw Osteonecrosis
Funder
National Health and Medical Research Council
Funding Amount
$121,751.00
Summary
Bisphosphonates are used in patients with bones that break easily due to conditions such as osteoporosis. Recent research suggests a possible association between these drugs and jaw bone breakdown called jaw osteonecrosis - a devastating condition with no current effective treatment. It is unclear why this condition affects only jaw bones. This study seeks to investigate if bacteria in the mouth, gum disease and saliva are involved in jaw osteonecrosis, which can then help to improve management.
The CCRE for Oral Health will focus on the prevention and treatment of oral diseases and disorders and their clinical consequences. Research will emphasise three areas of clinical care that are critical to the management of oral health, systemic health and general well-being: 1.Primary prevention to prevent disease onset 2. Diagnosis and risk prediction for oral conditions 3. Clinical intervention
Caries Initiation Across Childhood To Adulthood By Exposure To Water Fluoridation
Funder
National Health and Medical Research Council
Funding Amount
$198,297.00
Summary
This research program is expected to contribute to filling significant gaps in the understanding of factors determining the oral health of Australian children and young adults. The purpose of the project is to develop a better understanding of the outcome of long-term exposure to fluoridated water among young adults.
The South Australian Dental Longitudinal Study has been the first comprehensive dental longitudinal study of older adults to be conducted in Australia. Participants were aged 60+ years at the 1991 baseline data collection, and were a random sample of community-dwelling older adults in urban Adelaide and rural Mount Gambier. The 11-year follow-up data collection will build upon the previous study findings to provide important and new information about the onset and progression of oral diseases in ....The South Australian Dental Longitudinal Study has been the first comprehensive dental longitudinal study of older adults to be conducted in Australia. Participants were aged 60+ years at the 1991 baseline data collection, and were a random sample of community-dwelling older adults in urban Adelaide and rural Mount Gambier. The 11-year follow-up data collection will build upon the previous study findings to provide important and new information about the onset and progression of oral diseases in older Australians. It will also assist with the identification of general health and other characteristics (socio-demographic, medical, functional, cognitive, nutritional, swallowing, dental history, oral hygiene care, financial, social support and oral disorder social impact characteristics) that are associated with oral diseases in various groups of older adults. Groups of older adults within the study include those who are healthy and living in the community, those who are frail and use support services, and those who have moved into residential care. This information will assist both private and public health sectors, dental professionals and other health professionals with the identification of those older adults who are at high risk for developing oral diseases, such as those with dementia, those with physical disabilities, and those living in residential care. This 11-year data collection will be one of only 4 similar international studies currently being conducted, and will provide important comparison data for future studies of older Australians.Read moreRead less
Genetic, Environmental And Epigenetic Influences On Human Tooth Emergence: A Twin Study
Funder
National Health and Medical Research Council
Funding Amount
$334,053.00
Summary
By studying a large sample of twins and their families, we want to find out how important genetic and environmental factors are in determining when primary ("baby") teeth appear in the mouth. This will improve our knowledge about the process of tooth eruption which is still not clearly understood. It will also be important for clinicians in managing situations where teeth appear in the mouth either very early or very late compared with what is generally expected and to counsel families where the ....By studying a large sample of twins and their families, we want to find out how important genetic and environmental factors are in determining when primary ("baby") teeth appear in the mouth. This will improve our knowledge about the process of tooth eruption which is still not clearly understood. It will also be important for clinicians in managing situations where teeth appear in the mouth either very early or very late compared with what is generally expected and to counsel families where there are problems of dental development.Read moreRead less
Oral Health Research For The Australian Population
Funder
National Health and Medical Research Council
Funding Amount
$2,501,265.00
Summary
This program will build capacity and expertise in Australia s population health research workforce. The program will pursue the broad research theme adding value to oral health surveys . Over a period of five years, eight junior researchers will work on projects that enhance the value of six oral health surveys within the Australian Research Centre for Population Oral Health at The University of Adelaide. Projects will range from analysis of inflammation caused by periodontal (gum) disease in th ....This program will build capacity and expertise in Australia s population health research workforce. The program will pursue the broad research theme adding value to oral health surveys . Over a period of five years, eight junior researchers will work on projects that enhance the value of six oral health surveys within the Australian Research Centre for Population Oral Health at The University of Adelaide. Projects will range from analysis of inflammation caused by periodontal (gum) disease in the Australian population, to evaluation of school dental services provided over the last 30 years. Team investigators will work on these surveys to tackle public health problems confronting four distinct dental generations of Australians: _1) people in the oldest tooth loss generation who have lost, on average, half of their natural teeth; 2) the amalgam generation of middle-aged adults who had unprecedented numbers of cavities that are now filled - treatment that requires extensive maintenance and repair; 3) the younger fluoride generation that has historically-low rates of dental decay; 4) and today s pre-schoolers among whom there is disturbing evidence that oral disease is becoming concentrated within the most disadvantaged segments of the population. Their work will improve the information base needed to promote oral health and prevent oral illness in the Australian population.Read moreRead less