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How does the noncoding genome regulate gene expression in the human brain? The non-coding genome is recognized as a major player in orchestrating gene expression in higher eukaryotes. This project aims to identify regions of the human genome that are important for gene expression during neuronal differentiation and depolarisation (i.e. neural enhancers), and to investigate their evolutionary properties. The roles of non-coding DNA in regulating the dynamic gene expression patterns underlying com ....How does the noncoding genome regulate gene expression in the human brain? The non-coding genome is recognized as a major player in orchestrating gene expression in higher eukaryotes. This project aims to identify regions of the human genome that are important for gene expression during neuronal differentiation and depolarisation (i.e. neural enhancers), and to investigate their evolutionary properties. The roles of non-coding DNA in regulating the dynamic gene expression patterns underlying complex human brain functions remains to be elucidated. By combining transcriptome quantification and bioinformatics methods, this project will close an important knowledge gap in our understanding of transcriptional regulation underlying human brain function. This will provide benefits such as the potential to influence public health policy including in cognitive functions and aging.Read moreRead less
Uncovering microRNA decay regulation in mammalian cells. MicroRNAs (miRNAs) constitute a novel mechanism used by cells to regulate gene expression, however, very little is known about the mechanisms affecting miRNA accumulation. Characterisation of the kinetics of miRNA turnover is of paramount importance to establish the reliability of miRNAs as novel biomarkers. This project aims to characterise miRNA stability in mammalian cells, investigate mechanisms of turnover and establish their importan ....Uncovering microRNA decay regulation in mammalian cells. MicroRNAs (miRNAs) constitute a novel mechanism used by cells to regulate gene expression, however, very little is known about the mechanisms affecting miRNA accumulation. Characterisation of the kinetics of miRNA turnover is of paramount importance to establish the reliability of miRNAs as novel biomarkers. This project aims to characterise miRNA stability in mammalian cells, investigate mechanisms of turnover and establish their importance on the regulatory function of miRNAs. Such information is critical in the future development of targeted therapeutics.Read moreRead less
Spatio-temporal activation of genes in cells and mice. This project aims to develop novel genetic methods and instrumentation for the local, rapid and reversible activation of genes in cells and mice. This project expects to generate highly innovative light- and sound-based technologies that will permit to study living systems on the gene-level with unprecedented precision. Expected outcomes include new research and technology capacity to broadly address fundamental biological questions and to c ....Spatio-temporal activation of genes in cells and mice. This project aims to develop novel genetic methods and instrumentation for the local, rapid and reversible activation of genes in cells and mice. This project expects to generate highly innovative light- and sound-based technologies that will permit to study living systems on the gene-level with unprecedented precision. Expected outcomes include new research and technology capacity to broadly address fundamental biological questions and to create new applied processes. This project intends to provide significant benefits, such as enhanced knowledge generation, multidisciplinary training opportunities and patentable technologies.Read moreRead less
An integrated molecular approach to human gene regulation. This proposal aims to reveal how the interaction of nuclear RNA and protein molecules control gene regulation in the face of cell stress. To understand how genetic variation leads to changes in the expression of genes, we need new insights into the fundamental principles underpinning complex gene regulatory systems. Building on the discovery of paraspeckles, novel gene regulatory structures, this project will yield insights into gene reg ....An integrated molecular approach to human gene regulation. This proposal aims to reveal how the interaction of nuclear RNA and protein molecules control gene regulation in the face of cell stress. To understand how genetic variation leads to changes in the expression of genes, we need new insights into the fundamental principles underpinning complex gene regulatory systems. Building on the discovery of paraspeckles, novel gene regulatory structures, this project will yield insights into gene regulation that will help fill these knowledge gaps. This will provide a more comprehensive understanding of RNA-mediated gene regulation, and will open up new research opportunities to target RNA based gene regulatory complexes.Read moreRead less
Genetic networks regulating gene silencing by intronic repeat expansions . Changes in the copy number of DNA repeats are associated with phenotypic variations in several species. Expansions of DNA repeats underlie several human genetic diseases, including Friedreich’s ataxia. The molecular mechanisms that mediate these genetic abnormalities are currently unclear. This project aims to identify the novel genetic pathways and mechanisms mediating these genetic disorders. Using a plant model in an .... Genetic networks regulating gene silencing by intronic repeat expansions . Changes in the copy number of DNA repeats are associated with phenotypic variations in several species. Expansions of DNA repeats underlie several human genetic diseases, including Friedreich’s ataxia. The molecular mechanisms that mediate these genetic abnormalities are currently unclear. This project aims to identify the novel genetic pathways and mechanisms mediating these genetic disorders. Using a plant model in an innovative way this project will discover novel genes, uncover fundamental molecular mechanisms and reveal the genetic networks that govern gene silencing caused by triplet repeat expansions. This project, in addition to revealing fundamental biological mechanisms, will also have implications for human disease.
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The role of long non-coding RNAs in the epigenetic control of gene expression during endosperm development in plants. Elucidating the molecular events underlying the biology of seed development is important in both understanding plant development and in developing new methods to enhance the productivity and qualities of grain crops. In recent years it has become clear that various classes of non-coding RNAs have important roles in gene regulation. Of these non-coding RNAs, small RNAs (20-25 nucl ....The role of long non-coding RNAs in the epigenetic control of gene expression during endosperm development in plants. Elucidating the molecular events underlying the biology of seed development is important in both understanding plant development and in developing new methods to enhance the productivity and qualities of grain crops. In recent years it has become clear that various classes of non-coding RNAs have important roles in gene regulation. Of these non-coding RNAs, small RNAs (20-25 nucleotides) are beginning to be understood however less is known about the role and complexity of long non-coding RNAs. This project would identify new regulators of seed development that may lead to novel methods to increase grain yields, ultimately benefitting the Australian grains industry.Read moreRead less
Tracking the evolution of devil facial tumour disease. The evolution of devil facial tumour disease could have disastrous effects on not only the Tasmanian Devil population but also other closely related species. This project will investigate the evolution of the disease in order to determine how new strains of the disease are arising.
Deciphering the regulation and function of the epigenome in eukaryotic development and stress response. The epigenome is an additional regulatory code superimposed upon plant and animal genomes that controls how they operate. This project will aim to understand the information encoded in the epigenome and how it changes in development and environmental stress, enabling manipulation of its function in crops and correction of its dysfunction in disease.