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Discovery Early Career Researcher Award - Grant ID: DE230101081
Funder
Australian Research Council
Funding Amount
$458,238.00
Summary
Developing CRISPR Prime Editing for highly efficient precise gene editing. This project will further develop a recent breakthrough in gene editing technology named CRISPR prime editing to improve its performance in generating specific genome modifications in cells and organisms. This project expects to generate new knowledge regarding optimal strategies for its deployment as well as create novel enhanced versions of the technology. This would significantly enhance our ability to perform precise ....Developing CRISPR Prime Editing for highly efficient precise gene editing. This project will further develop a recent breakthrough in gene editing technology named CRISPR prime editing to improve its performance in generating specific genome modifications in cells and organisms. This project expects to generate new knowledge regarding optimal strategies for its deployment as well as create novel enhanced versions of the technology. This would significantly enhance our ability to perform precise genome modification of organisms and lead to substantial benefits for a vast array of applications in fundamental and applied biology. Future applications will include generating mutations in cells and model organisms for basic research and creating genetically enhanced agricultural animals or plants.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100346
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
Improving salt tolerance by optimising ion transport in chloroplasts. This project aims to discover the ion transport mechanisms and their molecular origins in chloroplasts that differentiate halophytes from glycophytes, allowing halophytes to optimise photosynthesis during salt stress. Yield losses in crop plants are linked to the effects of salt stress on their chloroplasts, but some plants maintain growth and yield irrespective of high soil salinity. This project will use biophysics to charac ....Improving salt tolerance by optimising ion transport in chloroplasts. This project aims to discover the ion transport mechanisms and their molecular origins in chloroplasts that differentiate halophytes from glycophytes, allowing halophytes to optimise photosynthesis during salt stress. Yield losses in crop plants are linked to the effects of salt stress on their chloroplasts, but some plants maintain growth and yield irrespective of high soil salinity. This project will use biophysics to characterise mutants deficient in targeted chloroplast transporters, comparing a model glycophyte and closely related halophyte. The expected outcome of these fundamental molecular is salt-tolerant crop plants.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100575
Funder
Australian Research Council
Funding Amount
$394,575.00
Summary
Getting to the root of salt-tolerance in the model cereal crop, barley. The root system is the first part of the plant to sense high concentrations of sodium and chloride ions in saline soils. The ability of roots to maintain growth in response to salinity is an important adaptation, increasing root soil exploration for nutrient and water uptake. The aim of this project is to identify the molecular mechanisms that control and regulate root growth in response to salinity using barley as a cereal ....Getting to the root of salt-tolerance in the model cereal crop, barley. The root system is the first part of the plant to sense high concentrations of sodium and chloride ions in saline soils. The ability of roots to maintain growth in response to salinity is an important adaptation, increasing root soil exploration for nutrient and water uptake. The aim of this project is to identify the molecular mechanisms that control and regulate root growth in response to salinity using barley as a cereal model. The knowledge gained in barley will provide important information for increasing salinity tolerance in other Australian cereal crops, most notably wheat.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150100837
Funder
Australian Research Council
Funding Amount
$354,000.00
Summary
Engineering enzymes controlling plant polysaccharide properties. This project will aim to use data to define how the synthesis and interconversion of nucleotide sugars is regulated and how this controls the properties of arabinoxylan in economically important plants. Dietary consumption of arabinoxylan reduces chronic diseases. Additionally, the attributes of arabinoxylan influence the cost of processing plant biomass. However, genetic control of the properties of the plant polysaccharide arabin ....Engineering enzymes controlling plant polysaccharide properties. This project will aim to use data to define how the synthesis and interconversion of nucleotide sugars is regulated and how this controls the properties of arabinoxylan in economically important plants. Dietary consumption of arabinoxylan reduces chronic diseases. Additionally, the attributes of arabinoxylan influence the cost of processing plant biomass. However, genetic control of the properties of the plant polysaccharide arabinoxylan is unresolved. A major control point in the partitioning of carbon from photosynthesis into arabinoxylan is the activity of sugar nucleotide interconverting enzymes. To characterise these enzymes, genomic, glycomic and enzyme kinetic data will be combined and the target enzymes will be modified in transgenic plants.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100804
Funder
Australian Research Council
Funding Amount
$370,000.00
Summary
Controlling chloride in plants. This project aims to discover novel components that control how plants acquire and manage chloride. Chloride is one of the two ions that commonly cause salt stress, which is a major threat to Australia’s agriculture. Regions affected by salinity are increasing worldwide due to changing weather patterns and poor land management. Knowledge of plant chloride management is underdeveloped, despite the reduction in crop yield caused by high chloride accumulation. The an ....Controlling chloride in plants. This project aims to discover novel components that control how plants acquire and manage chloride. Chloride is one of the two ions that commonly cause salt stress, which is a major threat to Australia’s agriculture. Regions affected by salinity are increasing worldwide due to changing weather patterns and poor land management. Knowledge of plant chloride management is underdeveloped, despite the reduction in crop yield caused by high chloride accumulation. The anticipated outcome of this project will inform strategies aimed at selecting for optimised chloride management traits to generate crops with improved yield.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100784
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Improving cereal grain quality using epigenetic regulators. The project aims to determine the epigenetic regulatory mechanisms that control cereal grain quality and yield under water-deficit and heat stress. The project will use next-generation sequencing to identify key epigenetic regulators and their functional target genes, which confer superior grain quality to elite genotypes under adverse environments. Project outcomes will benefit cereal breeding by providing more-tailored screening stra ....Improving cereal grain quality using epigenetic regulators. The project aims to determine the epigenetic regulatory mechanisms that control cereal grain quality and yield under water-deficit and heat stress. The project will use next-generation sequencing to identify key epigenetic regulators and their functional target genes, which confer superior grain quality to elite genotypes under adverse environments. Project outcomes will benefit cereal breeding by providing more-tailored screening strategies and superior parental germplasm with enhanced quality and yield. The development of nutritionally improved crops will benefit the Australian cereal industry and export opportunities.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100908
Funder
Australian Research Council
Funding Amount
$461,815.00
Summary
Maximising the beneficial impacts of mycorrhizal fungi on grain nutrition. This project aims to determine the effects of beneficial soil fungi on wheat and rice grain quality for human nutrition using an innovative combination of physiological, molecular and agronomic techniques. The project expects to generate fundamental knowledge in sustainable agriculture, to improve grain quality and value. Expected outcomes of this project include enhanced understanding of the mechanisms underlying improve ....Maximising the beneficial impacts of mycorrhizal fungi on grain nutrition. This project aims to determine the effects of beneficial soil fungi on wheat and rice grain quality for human nutrition using an innovative combination of physiological, molecular and agronomic techniques. The project expects to generate fundamental knowledge in sustainable agriculture, to improve grain quality and value. Expected outcomes of this project include enhanced understanding of the mechanisms underlying improved grain quality, and the capacity to use soil fungi to increase grain micronutrient concentrations and bioavailability. This should provide significant environmental and societal benefits, such as promotion of the sustainable use of agricultural soils and more nutritious grain products for human consumption.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100377
Funder
Australian Research Council
Funding Amount
$423,659.00
Summary
Facilitating control of Queensland fruit fly and other insect pests. This project aims to address the need for a Queensland fruit fly male-only sterile release strain for the national Sterile Insect Technique program to control this devastating Australian horticulture pest. By combining two molecular technologies in a new strain that responds to temperature cues to trigger development of only male flies, this project expects to produce twice as many sterile males for release to mate with wild fe ....Facilitating control of Queensland fruit fly and other insect pests. This project aims to address the need for a Queensland fruit fly male-only sterile release strain for the national Sterile Insect Technique program to control this devastating Australian horticulture pest. By combining two molecular technologies in a new strain that responds to temperature cues to trigger development of only male flies, this project expects to produce twice as many sterile males for release to mate with wild females in fruit fly outbreak areas, preventing production of the next generation. Expected outcomes include significant reduction in production costs and increased efficiency of the national sterile release program, facilitating control of this damaging pest to protect Australia's billion dollar horticultural industry.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160101394
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
Early developmental influences on neocortical organisation. This project seeks to identify the influence of preceding developmental stages on the correct formation of the brain. Development is a sequence of transformations where every stage depends on the outcome of previous stages. The project intends to examine how the early sensory periphery, early-born brain circuits, and intrinsic neuronal interactions affect the subsequent organisation of the cerebral cortex – a mammal-specific brain regio ....Early developmental influences on neocortical organisation. This project seeks to identify the influence of preceding developmental stages on the correct formation of the brain. Development is a sequence of transformations where every stage depends on the outcome of previous stages. The project intends to examine how the early sensory periphery, early-born brain circuits, and intrinsic neuronal interactions affect the subsequent organisation of the cerebral cortex – a mammal-specific brain region responsible for perception, motor planning and cognition. It expects to provide novel mechanistic and conceptual insights into the process of normal brain development and more general biological phenomena, such as development and evolution. It may also provide insights into several genetic and non-genetic causes of brain malformations.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100806
Funder
Australian Research Council
Funding Amount
$419,854.00
Summary
Towards herbicide cocktails with a new mode of action to avert resistance. This project aims to target herbicide resistant weeds which represent one of the largest threats to Australian and global food security. Targeting of unexplored pathways in plants to develop a novel herbicide strategy is expected to be achieved, and will include the structural and functional characterisation of key enzymes in these pathways. This project is expected to provide significant benefits for effective weed manag ....Towards herbicide cocktails with a new mode of action to avert resistance. This project aims to target herbicide resistant weeds which represent one of the largest threats to Australian and global food security. Targeting of unexplored pathways in plants to develop a novel herbicide strategy is expected to be achieved, and will include the structural and functional characterisation of key enzymes in these pathways. This project is expected to provide significant benefits for effective weed management to sustain Australia’s agricultural industry through enhanced food production from increased crop yields, whilst ensuring food security. These outcomes, coupled with decades of over-reliance on current herbicides, means there has never been a greater need for new and effective herbicides.Read moreRead less