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Understanding Influences On Oral Health Of Contemporary Australian Children
Funder
National Health and Medical Research Council
Funding Amount
$408,388.00
Summary
This study will contribute to an understanding of the factors affecting child oral health. Findings will have scientific value and relevance for the policy-making process in developing new methods of oral health prevention to target modifiable factors that will lead to improvement of oral health of children
Oral Human Papillomavirus Infection In Head And Neck Cancers And The General Population.
Funder
National Health and Medical Research Council
Funding Amount
$422,800.00
Summary
Mucosal cancers of the head and neck are the sixth most common type of cancer worldwide and are increasing in Australia. Human papillomaviruses (HPV), which are the major cause of cervical cancer and the cause of 5% of all human cancers, have recently also been implicated as a cause of some types of head and neck cancer, especially in patients younger than 50 years. In this project we will investigate how HPV infection regulates the expression of key genes in cancers of the head and neck, and ho ....Mucosal cancers of the head and neck are the sixth most common type of cancer worldwide and are increasing in Australia. Human papillomaviruses (HPV), which are the major cause of cervical cancer and the cause of 5% of all human cancers, have recently also been implicated as a cause of some types of head and neck cancer, especially in patients younger than 50 years. In this project we will investigate how HPV infection regulates the expression of key genes in cancers of the head and neck, and how that affects prognosis of this disease.Read moreRead less
Investigating The Mechanism And Consequences Of Cytotoxic Lymphocyte Detachment
Funder
National Health and Medical Research Council
Funding Amount
$419,180.00
Summary
Killer cells are white blood cells that destroy cancerous cells. To move to their next target they must quickly detach from a dying target. Failure of detachment results in excessive inflammation and tumour escape. This project will discover the detachment signals required to ‘release’ a locked-on killer cell. This will lead to a deeper understanding of immune pathology and new ways of treating cancer.
Improving Patient Outcomes In Leukaemia By Targeting Cancer Stem Cells
Funder
National Health and Medical Research Council
Funding Amount
$294,763.00
Summary
Blood cancers such as acute myeloid leukaemia (AML) are among the most deadly types of cancer and new treatments are desperately needed to improve patient’s survival in these diseases. AML cancer-causing stem cells survive by turning on immortalization programs and we hope to specifically kill these AML stem cells by blocking these crucial pathways. This includes things that control the way the cells divide and the way they respond to genetic damage as well as other novel pathways.
Using Human 3D Engineered Heart Tissue For Discovery Of Novel Biology And Novel Therapeutics
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
The goal of this project is to develop a model of miniaturised 3D human heart tissue for research into cardiac biology and also drug discovery applications. This will hopefully result in better, cheaper drugs in the future with less reliance on animal testing.
Using Connective Tissue Stem Cells To Treat Human Disease.
Funder
National Health and Medical Research Council
Funding Amount
$419,180.00
Summary
In our recent Cell paper (January 15, 2015), we reported our discovery of two new adult stem cells. One of these, the osteochondroreticular (OCR) bone stem cell (pronounced “ocker” stem cell) has a particular affinity for developing cartilage. We are testing if this cell could be used as a new treatment for osteoarthritis. The second new stem cell we discovered, is called the iRSC, and lies within the intestine. We are studying this cell in the development and treatment of bowel cancer.