Mechanisms of virus transport in indoor environments. The socio-economic benefits to Australia from the project will include the developed and validated model for quantification of virus spread and survival through aerosolation processes, which will become an important tool for: (i) prediction of the pathways of virus spread in indoor environment, and (ii) developing future directions for management and control for prevention or minimization the likelihood of human infections. The ultimate econo ....Mechanisms of virus transport in indoor environments. The socio-economic benefits to Australia from the project will include the developed and validated model for quantification of virus spread and survival through aerosolation processes, which will become an important tool for: (i) prediction of the pathways of virus spread in indoor environment, and (ii) developing future directions for management and control for prevention or minimization the likelihood of human infections. The ultimate economic benefit of this research will be reduction in health care costs and lost productivity. The research will also place Australia in the forefront of international progress and race towards toward better methods for virus spread prevention. Read moreRead less
In vitro expression and crystallization of proteins from the thermohalophile, Halothermothrix orenii. The project proposal is to develop enabling state-of-the-art protein technologies for biotechnology. We will for the first time develop a rapid and high throughput technique for the expression, purification and crystallisation of proteins from the extreme thermohalophile, Halothermothrix orenii. This important break through in protein technology will assist in determining structure and function ....In vitro expression and crystallization of proteins from the thermohalophile, Halothermothrix orenii. The project proposal is to develop enabling state-of-the-art protein technologies for biotechnology. We will for the first time develop a rapid and high throughput technique for the expression, purification and crystallisation of proteins from the extreme thermohalophile, Halothermothrix orenii. This important break through in protein technology will assist in determining structure and function relationships of thermohalophilic proteins. It is expected that such an understanding together with comparative bioinformatics will assist researchers to develop "designer proteins" with improved functions for different uses in biotechnology. It is also expected that this technology will be amenable for use with other thermohalophilic microbes.Read moreRead less
Gating, specificity and regulation of the YggB channel protein from Corynebacterium glutamicum. The proposed research will greatly contribute to our understanding of the functioning of a bacterial membrane channel/transporter, which has played a significant role in biotechnology of commercially important amino acids. A direct national benefit will result from establishing collaboration with a leading German laboratory providing expertise in protein biochemistry and molecular microbiology not ava ....Gating, specificity and regulation of the YggB channel protein from Corynebacterium glutamicum. The proposed research will greatly contribute to our understanding of the functioning of a bacterial membrane channel/transporter, which has played a significant role in biotechnology of commercially important amino acids. A direct national benefit will result from establishing collaboration with a leading German laboratory providing expertise in protein biochemistry and molecular microbiology not available in Australia. The acquired knowledge will present an original contribution which will have a strong impact on a very competitive field of molecular microbiology and biotechnology.Read moreRead less
Functional Analyses of Bacteria Involved in Enhanced Biological Phosphorus Removal from Wastewater. The abundant growth of blue-green algae in global waterways is substantially caused by phosphorus (P) release from wastewater treatment plants. This environmental drama can be mitigated against by P-accumulating bacteria partitioning the P inside their cells. The P-removal process often fails, but since the metabolism of P-accumulating bacteria is unknown, remedial actions are based on conjecture ....Functional Analyses of Bacteria Involved in Enhanced Biological Phosphorus Removal from Wastewater. The abundant growth of blue-green algae in global waterways is substantially caused by phosphorus (P) release from wastewater treatment plants. This environmental drama can be mitigated against by P-accumulating bacteria partitioning the P inside their cells. The P-removal process often fails, but since the metabolism of P-accumulating bacteria is unknown, remedial actions are based on conjecture. This fundamental, knowledge-generating project will address this shortfall and will develop methods to evaluate the activity of P-accumulating bacteria, contributing substantial understanding of their metabolism. The final goal is to promote stable, reproducible P-removal from wastewater.Read moreRead less
Development of symbiont based approaches to pest and disease control in sugarcane. This project aims to develop a new approach to the control of insect damage to sugarcane in Australia. It focuses on the manipulation of bacteria that are intimately associated with insects that feed on sugarcane, so as to decrease their ability to cause crop damage both directly through feeding and indirectly through the transmission of disease
Kernel methods for the analysis of whole bacterial genomes. This project addresses the fundamental scientific problem of the identification of regulatory regions and specific promoters within bacterial genomes, with a focus upon two organisms of great social, economic and bioterrism significance. From the machine learning perspective, the project will be the first to produce a kernel-based approach directly tailored to the problem of the detection of regulatory regions. The methods developed wil ....Kernel methods for the analysis of whole bacterial genomes. This project addresses the fundamental scientific problem of the identification of regulatory regions and specific promoters within bacterial genomes, with a focus upon two organisms of great social, economic and bioterrism significance. From the machine learning perspective, the project will be the first to produce a kernel-based approach directly tailored to the problem of the detection of regulatory regions. The methods developed will be made available through a straightforward web-based interface, allowing biologists throughout the world to utilize the approach as a tool to be applied to a progressively widening class of bacterial genomes, and even to eukaryotes. Read moreRead less
Rapid functional and taxonomic skin microbe characterisation. Rapid functional and taxonomic skin microbe characterisation. This project aims to develop methods to detect and characterise bioactive molecules released by skin microbes, and a novel microspectroscopy method for rapid taxonomic identification. This project will acquire independent spectra and develop classification algorithms, and participate in strategic planning for applications and product development. The expected outcomes from ....Rapid functional and taxonomic skin microbe characterisation. Rapid functional and taxonomic skin microbe characterisation. This project aims to develop methods to detect and characterise bioactive molecules released by skin microbes, and a novel microspectroscopy method for rapid taxonomic identification. This project will acquire independent spectra and develop classification algorithms, and participate in strategic planning for applications and product development. The expected outcomes from this project are research tools for skin microbiome modulation of immunity, and proof-of-concept data for future commercial product development. Potential commercial applications include microbial characterisation for biosecurity, agriculture, environmental and soil biology.Read moreRead less
Special Research Initiatives - Grant ID: SR0354702
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Australian Microbial Resources Research Network. The Australian Microbial Resources Research Network will provide integrated access to Australian collections of microorganisms and electronic access to bioinformation databases to meet national strategic needs for microbiological resources and to support the competitive development of the life sciences and biotechnology industries in Australia. The network will promote collaborative interactions and accelerate the discovery of Australian microorg ....Australian Microbial Resources Research Network. The Australian Microbial Resources Research Network will provide integrated access to Australian collections of microorganisms and electronic access to bioinformation databases to meet national strategic needs for microbiological resources and to support the competitive development of the life sciences and biotechnology industries in Australia. The network will promote collaborative interactions and accelerate the discovery of Australian microorganisms and microbial genomic information for innovative biotechnology and create new opportunities for bioindustries. The Network will link researchers and foster the discovery and exploitation of Australian microbial resources and make these resources and associated information available for applications in research, industry and education.Read moreRead less
Disulfide catalysis and protein folding in bacterial virulence. The molecular mechanisms that underpin disulfide bond formation have had a major impact on our understanding of protein folding and function. This project will make a major contribution to fundamental areas of disulfide catalysis pathways in bacterial pathogens and thus help maintain a strong international profile for Australian research in this field. The work will lead to training of research scientists and students in techniques ....Disulfide catalysis and protein folding in bacterial virulence. The molecular mechanisms that underpin disulfide bond formation have had a major impact on our understanding of protein folding and function. This project will make a major contribution to fundamental areas of disulfide catalysis pathways in bacterial pathogens and thus help maintain a strong international profile for Australian research in this field. The work will lead to training of research scientists and students in techniques that include molecular genetics, protein biochemistry and structural biology. Our findings may impact future directions for vaccine research on pathogens that cause life threatening infections in humans and therefore lead to improved health and reduced health care expenditure.Read moreRead less
Mechanisms of subversion of malarial immunity. This project will aim to understand how the Malaria parasite, which causes one of the world’s deadliest diseases, evades immunity. It will provide novel understanding of immunity against malaria and impact on current strategies to develop an efficacious vaccine or treatment for malaria.