A Randomised Controlled Trial Of A Code Game Alarm Compared With A Standard Alarm For Treating Nocturnal Enuresis
Funder
National Health and Medical Research Council
Funding Amount
$349,740.00
Summary
Bedwetting affects 10% of school-aged children. It has psychosocial and cognitive effects on sufferers which is reversible with appropriate treatment. First line treatment for bedwetting is alarm therapy. 1-3 fail alarm treatment becaues of not waking to alarm noise. A novel alarm which enhances wakening has been developed and predicts to be 80-95% effective. This study compares the novel alarm to a standard alarm for treating bedwetting.This simple devise can be used in the home setting.
Pharmacodynamics In Liver Disease And In Liver Surgery
Funder
National Health and Medical Research Council
Funding Amount
$899,646.00
Summary
The liver is the main organ in the body for drug metabolism and detoxification. This work seeks to address the poorly understood question: what is the in vivo disposition and response in liver of the drugs for treatment of liver diseases? The results of this work will help us better design new drugs and choose the most effective drugs for liver disease. The research may also help us find a better strategy for liver transplantation and thus improve success rates.
Gammma Tocopherol Is An Important Dietary Antiinflammatory Agent.
Funder
National Health and Medical Research Council
Funding Amount
$281,636.00
Summary
Cardiovascular disease is the major source of death in developed countries. In Australia it accounts for more deaths than cancer and is associated with considerable economic cost. The use of antioxidant vitamin supplements for reduction of heart disease risk is now discouraged because several large studies with vitamin E (containing one form of vitamin E called alpha-tocopherol) have shown no benefit. However, there remains a major discrepancy between intervention studies using pure alpha-tocoph ....Cardiovascular disease is the major source of death in developed countries. In Australia it accounts for more deaths than cancer and is associated with considerable economic cost. The use of antioxidant vitamin supplements for reduction of heart disease risk is now discouraged because several large studies with vitamin E (containing one form of vitamin E called alpha-tocopherol) have shown no benefit. However, there remains a major discrepancy between intervention studies using pure alpha-tocopherol and population studies showing a benefit of diet derived antioxidants. We believe that this project will help clarify this discrepancy and provide data which may provide evidence for functional foods enriched with another form of vitamin E called gamma-tocopherol. Gamma-tocopherol is common in some foods and it may have different properties compared to alpha-tocopherol. We have already established that supplementation for six weeks with gamma-tocopherol leads to a marked increase in blood and tissue levels of gamma-tocopherol. Dietary gamma-tocopherol has potential antiinflammatory activity. This project will study how gamma-tocopherol may work as an antiinflammatory agent which could help to protect against heart disease. The project will clarify the potential role of dietary gamma-tocopherol in cardiovascular disease and strengthen the recommendation for mixed dietary 'antioxidants' in place of pure supplements such as alpha-tocopherol.Read moreRead less
SES And Injury In Children: A Cohort Study To Identify And Measure The Effects Of Preventable Mediating Factors
Funder
National Health and Medical Research Council
Funding Amount
$360,505.00
Summary
While changing an individual or group SES is at best a long term and challenging social objective, proximal risk factors for injury can be more readily modified. Once the proximal risk factor differential across SES groups has been adequately delineated, then the possibility arises for targeted public health intervention to redress the SES differential in the incidence of injury. The sophistication of the proposed modeling will result in a good assessment of the best point to target.
A Comparison Of Arthroscopic Synovial Biopsy Based Targeted Biologic Therapy Versus Conventional Therapy In Rheumatoid Arthritis
Funder
National Health and Medical Research Council
Funding Amount
$133,351.00
Summary
This proposed study will investigate if treatment of rheumatoid arthritis (RA) based on biopsy of affected joints’ lining is better than standard therapy (not based on the results of biopsy). Current strategies to treat RA not infrequently result in incomplete disease suppression with potentially resultant joint damage, in part because of lack of definite guidelines to individualise treatment. We propose that therapy on the basis of the analysis of biopsy of joint lining will lead to better dise ....This proposed study will investigate if treatment of rheumatoid arthritis (RA) based on biopsy of affected joints’ lining is better than standard therapy (not based on the results of biopsy). Current strategies to treat RA not infrequently result in incomplete disease suppression with potentially resultant joint damage, in part because of lack of definite guidelines to individualise treatment. We propose that therapy on the basis of the analysis of biopsy of joint lining will lead to better disease control than the currently prevalent approach.Read moreRead less
Microbial Restoriation In Crohn's Disease: A Randomised Trial Of Faecal Microbial Transplanatation In Crohn's Disease
Funder
National Health and Medical Research Council
Funding Amount
$487,123.00
Summary
Crohn's disease causes inflammation and damage to the digestive tract. Compelling evidence suggests that the bacteria in the gut play an important role in the onset of disease. Changing the gut bacteria through the administration of healthy stool to a patient, faecal microbiota transplantation (FMT), is safe and may be effective. This placebo controlled trial will determine whether FMT (delivered via capsule) can control inflammation in Crohn's. Results will change current treatment paradigms.
A La CaRT: Australasian Laparoscopic Cancer Of The Rectum Trial. A Phase III Prospective Randomised Trial Comparing Laparoscopic-assisted Resection Versus Open Resection For Rectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$599,054.00
Summary
The major treatment for rectal cancer is surgical removal of tumour with a large cut through the abdomen. There is a newer, less invasive procedure known as laparoscopic resection which enables the same surgery to be performed using a scope inserted in the abdomen and another smaller incision for removal of the tumour. This study is being conducted to determine whether the newer procedure is as safe and effective as the current procedure. Patients on the trial will be given either laparoscopi
Improving Outcomes For People With Depression In Community Settings: A Cluster RCT
Funder
National Health and Medical Research Council
Funding Amount
$803,554.00
Summary
Depression affects 350 million people worldwide. Given the pivotal role of primary care in the management of depression, effective strategies are needed to assist GPs in the delivery of patient-centred depression care. This study will test the effectiveness of providing GPs with education; as well as feedback about patients’ self-reported depressive scores using a standardised instrument and perceived need and preferences for help. This cluster RCT will be the first Australian trial of its kind.