Redefining the immune landscape of the human ocular surface. At the ocular surface, the cornea and limbus need to mount effective immune responses to maintain corneal transparency for clear vision. The current paradigm is that the human cornea houses the same innate immune cell subsets (dendritic cells and macrophages) as naïve mice in pathogen-free facilities. Our pilot data challenge this premise, with early evidence that innate and adaptive cells (T cells) coexist in normal human corneas. Int ....Redefining the immune landscape of the human ocular surface. At the ocular surface, the cornea and limbus need to mount effective immune responses to maintain corneal transparency for clear vision. The current paradigm is that the human cornea houses the same innate immune cell subsets (dendritic cells and macrophages) as naïve mice in pathogen-free facilities. Our pilot data challenge this premise, with early evidence that innate and adaptive cells (T cells) coexist in normal human corneas. Integrating state-of-the-art techniques, we will advance understanding of immune regulation at the human ocular surface by comprehensively defining immune cell biology and dynamics. We will define the effect of age on immune cells in these tissues, and relationships between the tear proteome and cell behaviours.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101129
Funder
Australian Research Council
Funding Amount
$425,948.00
Summary
Two-Dimensional Material Tandem Detectors for Polarimetry and Spectroscopy. The aim of this project is to leverage the fundamental advantages that two-dimensional (2D) materials could provide to vertically-stacked (tandem) photodetectors. The strong absorption, tunable bandgap and polarisation dependence that many 2D materials exhibit, provides a means by which to detect properties of light. This topic is significant because it could overcome current cost/performance issues of tandem detectors, .... Two-Dimensional Material Tandem Detectors for Polarimetry and Spectroscopy. The aim of this project is to leverage the fundamental advantages that two-dimensional (2D) materials could provide to vertically-stacked (tandem) photodetectors. The strong absorption, tunable bandgap and polarisation dependence that many 2D materials exhibit, provides a means by which to detect properties of light. This topic is significant because it could overcome current cost/performance issues of tandem detectors, enabling widespread usage. The expected project outcome is the development of a novel tandem 2D detector, which as a single detector/pixel, can extract the intensity, polarisation and wavelength region of incoming light. This would provide benefits for many future applications, including machine vision and aerial surveying.Read moreRead less
Ytterbium fibre laser with diamond: new laser threshold magnetometry method. This project aims to create a novel class of hybrid optical fibres that open new vistas for magnetic field detection at ambient temperatures in noisy environments. The multidisciplinary project will develop the first fibre laser threshold magnetometry platform that breaks through diamond magnetometry sensitivity limits by cross-cutting established fibre laser technology with the new diamond-glass fibres and magnetometry ....Ytterbium fibre laser with diamond: new laser threshold magnetometry method. This project aims to create a novel class of hybrid optical fibres that open new vistas for magnetic field detection at ambient temperatures in noisy environments. The multidisciplinary project will develop the first fibre laser threshold magnetometry platform that breaks through diamond magnetometry sensitivity limits by cross-cutting established fibre laser technology with the new diamond-glass fibres and magnetometry concepts recently invented by the investigators. Envisaged significant benefits include non-invasive detection of magnetic fields in hard-to-access regions, an area of key interest for remote detection of submarines, early sensing of aircraft corrosion, deep brain imaging of neuronal activities and mineral exploration.Read moreRead less
Ultrafast tracking of physiological processes in the human eye. Recent developments in high-resolution imaging allow individual cells in the living eye to be studied at very high speeds. This project aims to explore a new class of scientific observations of rapid phenomena including: the capture and conversion of light energy to electrical energy, the spread of pressure waves through delicate networks of blood vessels, and fast eye movements used to navigate the visual scene. This project expect ....Ultrafast tracking of physiological processes in the human eye. Recent developments in high-resolution imaging allow individual cells in the living eye to be studied at very high speeds. This project aims to explore a new class of scientific observations of rapid phenomena including: the capture and conversion of light energy to electrical energy, the spread of pressure waves through delicate networks of blood vessels, and fast eye movements used to navigate the visual scene. This project expects to generate new knowledge about these processes using state of the art technology, to reveal more about how the eye and visual system work. Our novel measures of physiological function will offer significant future benefit in the early diagnosis and treatment of disorders occurring at the cellular level.Read moreRead less
Diamond-based wideband radiofrequency fibre-optic sensor. This project aims to address the growing problem of ultra-wide radiofrequency signal monitoring. Developing a rugged and portable solution for whole-spectrum monitoring is a critical unmet need for Defence and other industries, and an important scientific challenge. Our approach is based on a diamond radio frequency sensor with fibre-optic readout. The project is expected to generate knowledge in the areas of quantum science and photonics ....Diamond-based wideband radiofrequency fibre-optic sensor. This project aims to address the growing problem of ultra-wide radiofrequency signal monitoring. Developing a rugged and portable solution for whole-spectrum monitoring is a critical unmet need for Defence and other industries, and an important scientific challenge. Our approach is based on a diamond radio frequency sensor with fibre-optic readout. The project is expected to generate knowledge in the areas of quantum science and photonics by integrating advanced optical fibres with quantum-grade diamond. Expected outcomes of the project include the development of a strategic academic and industry alliance through the establishment of a sovereign capability that will benefit Australia in the areas of cybersecurity and advanced manufacturing.Read moreRead less
Multi-colour ultrashort soft X-ray pulses. This project aims to create multi-colour, ultrashort, highly coherent, bright pulses of soft X-rays based on high-harmonic generation in a table-top multiple-section gas cell. Studying multi-electronic and non-adiabatic processes and other fundamental aspects such as multi-electronic correlations and non-Born-Oppenheimer vibronic couplings in complex molecules is a major challenge in current ultrafast photochemistry research. This project will use multi ....Multi-colour ultrashort soft X-ray pulses. This project aims to create multi-colour, ultrashort, highly coherent, bright pulses of soft X-rays based on high-harmonic generation in a table-top multiple-section gas cell. Studying multi-electronic and non-adiabatic processes and other fundamental aspects such as multi-electronic correlations and non-Born-Oppenheimer vibronic couplings in complex molecules is a major challenge in current ultrafast photochemistry research. This project will use multiple driving pulses with different carrier frequencies to control the spectral properties and time delay of the pulses. It will use the soft X-ray source to develop an ideal platform for studying multi-electronic and non-adiabatic processes, multi-electronic correlations and non-Born-Oppenheimer vibronic couplings in complex molecules. This is expected to advance materials science, paving the way to soft X-ray technologies.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100086
Funder
Australian Research Council
Funding Amount
$489,250.00
Summary
A platform for probing nanoscale magnetic states under multiple actuations. The proposed facility offers unique capabilities to investigate the interactions of spin with charge and lattice under external stimuli of light illumination, mechanical stress and voltage bias at various temperatures in a wide range of functional materials. Precise laser magnetometry and video-rate Kerr microscopy are integrated in a single magneto-optic Kerr effect (MOKE) system. This platform also aims to provide opti ....A platform for probing nanoscale magnetic states under multiple actuations. The proposed facility offers unique capabilities to investigate the interactions of spin with charge and lattice under external stimuli of light illumination, mechanical stress and voltage bias at various temperatures in a wide range of functional materials. Precise laser magnetometry and video-rate Kerr microscopy are integrated in a single magneto-optic Kerr effect (MOKE) system. This platform also aims to provide optical magnetic circular dichroism (OMCD) to assess electronic structures of semiconductors and biomedical materials. It will facilitate multidisciplinary research collaborations between academics and industries to advance next-generation spintronics, optoelectronics, energy conversion and storage, and biomedical technologies.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190101514
Funder
Australian Research Council
Funding Amount
$352,473.00
Summary
Nanodroplet platforms for engineering novel nanocarbon structures. This project aims to exploit surface nanodroplet array platforms to construct multi-scale level assembly of nanometer-scale carbon materials. The project expects to advance knowledge on the interactions between droplets and carbon nanomaterials to enable controlled construction of nanocarbon based optoelectric devices. Successful adoption of nanocarbon material-based optoelectronic devices by the energy conversion industry has th ....Nanodroplet platforms for engineering novel nanocarbon structures. This project aims to exploit surface nanodroplet array platforms to construct multi-scale level assembly of nanometer-scale carbon materials. The project expects to advance knowledge on the interactions between droplets and carbon nanomaterials to enable controlled construction of nanocarbon based optoelectric devices. Successful adoption of nanocarbon material-based optoelectronic devices by the energy conversion industry has the potential to increase efficiency of conversion and reduce the cost of manufacture. The expected outcomes are large scale and well-ordered nanocarbon structures with excellent electronic and optical properties.Read moreRead less
Diamond Voltage Microscopy: A new tool for neuroscience. This project aims to develop an optoelectronic voltage imaging microscope that can capture the sub-cellular electrical dynamics of neuronal networks. This will be achieved by leveraging the team’s technological breakthrough in the production of near-surface fluorescent defects in semiconducting diamond, which can optically detect local changes in electric potential. The expected outcomes of the project are a new microscopy modality and exp ....Diamond Voltage Microscopy: A new tool for neuroscience. This project aims to develop an optoelectronic voltage imaging microscope that can capture the sub-cellular electrical dynamics of neuronal networks. This will be achieved by leveraging the team’s technological breakthrough in the production of near-surface fluorescent defects in semiconducting diamond, which can optically detect local changes in electric potential. The expected outcomes of the project are a new microscopy modality and experimental framework which enables in vitro electrophysiological stimulation and recording at network scale and with single-synapse resolution. This will provide a much-needed tool to understand mechanisms underlying learning, memory formation and recall, and cognitive decline.Read moreRead less
Indoor Photovoltaics Enabled by Wide-Bandgap Perovskite Quantum Dots. This project aims to develop a high-efficiency indoor photovoltaic (PV) technology to provide reliable low-cost power in the multi-billion dollar “Internet of Things” (IoT) market. There are currently no devices that meet the requirements for maximum operating efficiency under indoor illumination. We propose to solve this problem by fabricating PV cells using colloidal perovskite quantum dots that offer class-leading stability ....Indoor Photovoltaics Enabled by Wide-Bandgap Perovskite Quantum Dots. This project aims to develop a high-efficiency indoor photovoltaic (PV) technology to provide reliable low-cost power in the multi-billion dollar “Internet of Things” (IoT) market. There are currently no devices that meet the requirements for maximum operating efficiency under indoor illumination. We propose to solve this problem by fabricating PV cells using colloidal perovskite quantum dots that offer class-leading stability and band gap tunability across the required range, enabled by quantum confinement. The outcome is the development of integrated self-powered IoT devices potentially impacting Advanced Manufacturing growth in Energy, Cyber Security, Food and Agribusiness, as all of these will ultimately rely on networked smart devices.Read moreRead less