Epilepsy: Molecular Basis And Mechanisms In The Era Of Functional Genomics
Funder
National Health and Medical Research Council
Funding Amount
$12,062,533.00
Summary
The team comprises of neurologists with a special interest in epilepsy (both adult and child) molecular geneticists, physiologists and brain imaging specialists. The team leads the world in the discovery of the genetic causes of epilepsy and epilepsy associated with intellectual disability. The team will continue to identify the genes underlying epilepsy, and study how genetic variations result in the development of seizures and will continue to develop advanced imaging techniques for these stud ....The team comprises of neurologists with a special interest in epilepsy (both adult and child) molecular geneticists, physiologists and brain imaging specialists. The team leads the world in the discovery of the genetic causes of epilepsy and epilepsy associated with intellectual disability. The team will continue to identify the genes underlying epilepsy, and study how genetic variations result in the development of seizures and will continue to develop advanced imaging techniques for these studies. This will include extensive laboratory studies, including the development of mice with the exact mutations that we find in the human condition. Stateof-the-art imaging techniques with magnetic resonance and positron emission tomography are used in human subjects to further understand the effects of the mutations on the structure and function of the brain. This will allow deep understanding of how seizures develop and may lead to new diagnostic methods and treatments. The laboratory and clinical aspects of the research are tightly integrated in this internationally leading collaborative program.Read moreRead less
Untangling Complex Molecular Spectra with an Optical Frequency Comb. The exhaled breath is a rich source of information about the inner life of the human body - but untangling this complicated molecular mixture into a quantitative measurement of its constituent components is currently an unsolved problem. This project aims to develop a new instrument that leverages the Nobel Prize winning technology of the optical frequency comb to enable analysis of such mixtures. It is expected that by combini ....Untangling Complex Molecular Spectra with an Optical Frequency Comb. The exhaled breath is a rich source of information about the inner life of the human body - but untangling this complicated molecular mixture into a quantitative measurement of its constituent components is currently an unsolved problem. This project aims to develop a new instrument that leverages the Nobel Prize winning technology of the optical frequency comb to enable analysis of such mixtures. It is expected that by combining a frequency comb source, with an innovative detector and a highly sensitive sampling system, a real-time spectral signature of each sample will be generated. Computational techniques developed by the radio astronomy community will then be used to extract concentrations of individual molecular components at the parts-per-billion level.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100104
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Capability for the fabrication and characterisation of mid-infrared photonic materials. The proposed facility will support the development of new glass materials suitable for transmitting and generating light in the mid-infrared spectral region. This research will allow Australia to lead the world in developing new technologies that make use of the mid-infrared region of the electromagnetic spectrum. Particular applications that will flow from this research include the development of new optical ....Capability for the fabrication and characterisation of mid-infrared photonic materials. The proposed facility will support the development of new glass materials suitable for transmitting and generating light in the mid-infrared spectral region. This research will allow Australia to lead the world in developing new technologies that make use of the mid-infrared region of the electromagnetic spectrum. Particular applications that will flow from this research include the development of new optical fibre-based laser sources for defence and surgery, new technologies for detecting and treating cancer, and other in-vivo detection methods.Read moreRead less
Ultrafast, near infrared laser sources using fibre-based optical parametric oscillators. This project will use microstructured optical fibres and nonlinear optics to create compact and cheap laser sources in the near infrared spectrum to replace the bulky and expensive devices in many spectroscopic and biophotonic applications today. The work will further enhance Australia's standing in the field of nonlinear optics and optical fibres.
Light-matter interactions using optical fibres. This program will allow Australia to build on established excellence in photonics to extend the impact of optical fibres beyond telecommunications to applications throughout the sciences. Pioneering work on materials and structures will form a platform technology enabling innovations in areas as diverse as water quality monitoring and corrosion detection. In addition, new optical fibres will be developed for the needs of the Australian Defence Forc ....Light-matter interactions using optical fibres. This program will allow Australia to build on established excellence in photonics to extend the impact of optical fibres beyond telecommunications to applications throughout the sciences. Pioneering work on materials and structures will form a platform technology enabling innovations in areas as diverse as water quality monitoring and corrosion detection. In addition, new optical fibres will be developed for the needs of the Australian Defence Force and associated industries. Fibre-based approaches to problems in biology will ultimately lead to an improved understanding of molecular structures and new tools for manipulating biomolecules.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100161
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
Next generation of extrusion capability for the fabrication of advanced photonic structures. The cutting-edge extrusion capability will enable the development of novel optical fibres and photonic materials with a wide range of structures in high precision and reproducibility. These new materials will lead to breakthroughs in the emerging research areas of nanophotonics, quantum communication, biosensing and mid-infrared light sources.
Levitated Quantum Optomechanics with Trapped, Rotating Microparticles. This project will develop techniques for trapping, rotating and cooling microscopic particles in vacuum for exquisitely accurate studies of sensors and of fundamental physics at the classical-quantum interface - namely quantum vacuum friction. It will result in the establishment of an internationally recognised activity in rotational levitated optomechanics and expand Australia's presence in the field of quantum photonics. It ....Levitated Quantum Optomechanics with Trapped, Rotating Microparticles. This project will develop techniques for trapping, rotating and cooling microscopic particles in vacuum for exquisitely accurate studies of sensors and of fundamental physics at the classical-quantum interface - namely quantum vacuum friction. It will result in the establishment of an internationally recognised activity in rotational levitated optomechanics and expand Australia's presence in the field of quantum photonics. It has the potential for commercial benefit in areas including photonics, sensors and advanced manufacturingRead moreRead less
Australian Laureate Fellowships - Grant ID: FL210100099
Funder
Australian Research Council
Funding Amount
$3,401,828.00
Summary
The Intelligent Microscope - novel optical imaging at depth. While optical methods for imaging are used extensively, achieving wide-field imaging through scattering media with high resolution and depth is a major challenge, due mainly to the limited penetration depth of light. This proposal aims to transform wide-field optical imaging through a new ‘intelligent’ microscopy able to capture 3D volumetric images. Innovations in shaping light in both space and time will be combined in a holistic wa ....The Intelligent Microscope - novel optical imaging at depth. While optical methods for imaging are used extensively, achieving wide-field imaging through scattering media with high resolution and depth is a major challenge, due mainly to the limited penetration depth of light. This proposal aims to transform wide-field optical imaging through a new ‘intelligent’ microscopy able to capture 3D volumetric images. Innovations in shaping light in both space and time will be combined in a holistic way with computational analysis to extract images from deep within the sample at extraordinary levels of detail. Major benefits of the research range from next-generation tools for enhanced discovery of biological and physical materials, to new Australian start-ups for new imaging and microscopy devices.Read moreRead less
Compact and versatile chip lasers for three-dimensional mine surveying. This project will bring together a world leading mine survey company, The University of Adelaide and Macquarie University researchers, to develop an 'eye-safe' micro laser for high resolution three-dimensional laser-mapping. The recently developed and patented 'chip' laser will allow the realisation of a compact, enhanced range laser-radar with unmatched resolution.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0346888
Funder
Australian Research Council
Funding Amount
$288,000.00
Summary
3-D Optical Surface Profiler. Establishing a state-of-the-science 3-D optical surface profiler will enable macroscopic, microscopic and nanoscopic profiling of surfaces over a very broad range of research programs including, laser cleaning and surface modification, laser precision microfabrication, surface, materials and device characterisation and optical physics applications. The importance and significance of these projects has already been established by the projects having competitive fundi ....3-D Optical Surface Profiler. Establishing a state-of-the-science 3-D optical surface profiler will enable macroscopic, microscopic and nanoscopic profiling of surfaces over a very broad range of research programs including, laser cleaning and surface modification, laser precision microfabrication, surface, materials and device characterisation and optical physics applications. The importance and significance of these projects has already been established by the projects having competitive funding. The instrument will undoubtedly support many additional research programs. It is similar to an Atomic-Force-Microscope or stylus profilometer but has significant additional capabilites. These include profiling much larger areas at sub-nanometre resolution and the non-contact nature of the technique. These features will enable surface characterisation that can not be achieved by other means.Read moreRead less