Dynamic Mechano-Microscopy for use in Mechanobiology . We will develop an innovative microscope that will enable new discoveries in biology. Most microscopes form images of a sample's optical properties, instead we will image a sample's mechanical properties. The reason our novel approach is needed is that cell behaviour depends on the stiffness of it's environment, but current microscopes are unable to image this. Our microscope will provide insights in biology that can improve our understandi ....Dynamic Mechano-Microscopy for use in Mechanobiology . We will develop an innovative microscope that will enable new discoveries in biology. Most microscopes form images of a sample's optical properties, instead we will image a sample's mechanical properties. The reason our novel approach is needed is that cell behaviour depends on the stiffness of it's environment, but current microscopes are unable to image this. Our microscope will provide insights in biology that can improve our understanding of cells, the building blocks of life. We will achieve this by: 1. Developing a microscope that combines microscopic resolution with rapid imaging; 2: Developing the capability to image both within the cell and its surrounding environment; and 3. Using our microscope to make discoveries in biology.Read moreRead less
Untangling Complex Molecular Spectra with an Optical Frequency Comb. The exhaled breath is a rich source of information about the inner life of the human body - but untangling this complicated molecular mixture into a quantitative measurement of its constituent components is currently an unsolved problem. This project aims to develop a new instrument that leverages the Nobel Prize winning technology of the optical frequency comb to enable analysis of such mixtures. It is expected that by combini ....Untangling Complex Molecular Spectra with an Optical Frequency Comb. The exhaled breath is a rich source of information about the inner life of the human body - but untangling this complicated molecular mixture into a quantitative measurement of its constituent components is currently an unsolved problem. This project aims to develop a new instrument that leverages the Nobel Prize winning technology of the optical frequency comb to enable analysis of such mixtures. It is expected that by combining a frequency comb source, with an innovative detector and a highly sensitive sampling system, a real-time spectral signature of each sample will be generated. Computational techniques developed by the radio astronomy community will then be used to extract concentrations of individual molecular components at the parts-per-billion level.Read moreRead less
In vivo molecular imaging using engineered affinity reagents and fluorescent laser scanning confocal endomicroscopy. The goal of this project is to develop laser scanning confocal endomicroscopy as a tool for basic scientific discovery and rapid detection of disease biomarkers. The cutting-edge instrument and associated technologies will provide scientists with unprecedented access to dynamic biological processes as they occur in real-time. In addition, it will enable the development of virtual ....In vivo molecular imaging using engineered affinity reagents and fluorescent laser scanning confocal endomicroscopy. The goal of this project is to develop laser scanning confocal endomicroscopy as a tool for basic scientific discovery and rapid detection of disease biomarkers. The cutting-edge instrument and associated technologies will provide scientists with unprecedented access to dynamic biological processes as they occur in real-time. In addition, it will enable the development of virtual biopsies and instant diagnosis without the need for costly and time-consuming histopathological reports. Thus, it will not only drive transformative research but also transform health care delivery. It will also be a major boost to the Australian biotechnology industry with potential for enormous economic benefits.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150101005
Funder
Australian Research Council
Funding Amount
$378,288.00
Summary
Miniaturised fibre-optic probes for biomedical image and sensor data fusion. The project aims to develop new types of tiny biomedical imaging devices based on optical fibres that can be inserted into the body via hypodermic needles or catheters. These devices will have the ability to generate a three-dimensional image of the tissue region. As the devices will also be able to sense biochemical or mechanical properties of the tissue, they can be used to differentiate healthy from diseased tissue. ....Miniaturised fibre-optic probes for biomedical image and sensor data fusion. The project aims to develop new types of tiny biomedical imaging devices based on optical fibres that can be inserted into the body via hypodermic needles or catheters. These devices will have the ability to generate a three-dimensional image of the tissue region. As the devices will also be able to sense biochemical or mechanical properties of the tissue, they can be used to differentiate healthy from diseased tissue. These minimally invasive devices will produce information-rich multidimensional fused image and sensor data, opening up new possibilities for biologists and medical researchers to study disease progression and treatment in living animals and humans, with great potential for scientific discovery.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100509
Funder
Australian Research Council
Funding Amount
$436,482.00
Summary
Going Fourth: ruling light with pure-quartic solitons. This project aims to develop a novel integrated high-energy light source through the combination of nanoscience and optics. The core research of this project addresses the energy limitation inherent to the current technology which has hindered its use in real applications. Expected outcomes include new knowledge, with publication in world-class scientific journals, and disruptive technological capabilities in miniaturized photonics. The expe ....Going Fourth: ruling light with pure-quartic solitons. This project aims to develop a novel integrated high-energy light source through the combination of nanoscience and optics. The core research of this project addresses the energy limitation inherent to the current technology which has hindered its use in real applications. Expected outcomes include new knowledge, with publication in world-class scientific journals, and disruptive technological capabilities in miniaturized photonics. The expected benefit is to generate high-energy pulses from a battery powered micro-chip that could enhance spectroscopy sensing devices for real-world applications, outside laboratories. This project will strengthen Australian capabilities and expertise in cutting-edge nanotechnology and photonics.Read moreRead less
Levitated Quantum Optomechanics with Trapped, Rotating Microparticles. This project will develop techniques for trapping, rotating and cooling microscopic particles in vacuum for exquisitely accurate studies of sensors and of fundamental physics at the classical-quantum interface - namely quantum vacuum friction. It will result in the establishment of an internationally recognised activity in rotational levitated optomechanics and expand Australia's presence in the field of quantum photonics. It ....Levitated Quantum Optomechanics with Trapped, Rotating Microparticles. This project will develop techniques for trapping, rotating and cooling microscopic particles in vacuum for exquisitely accurate studies of sensors and of fundamental physics at the classical-quantum interface - namely quantum vacuum friction. It will result in the establishment of an internationally recognised activity in rotational levitated optomechanics and expand Australia's presence in the field of quantum photonics. It has the potential for commercial benefit in areas including photonics, sensors and advanced manufacturingRead moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100934
Funder
Australian Research Council
Funding Amount
$439,082.00
Summary
Taming the light: full control in polarisation, space, and time. This project aims to develop two prototype optical beam shaping systems, culminating in the demonstration of new high-power optical fibre amplifiers. This novel ability to control all the properties of light enables the generation of optical beams that were only theoretical ideas but never previously implemented experimentally. This advanced technology can potentially open new ways in which objects can be probed using light. Expect ....Taming the light: full control in polarisation, space, and time. This project aims to develop two prototype optical beam shaping systems, culminating in the demonstration of new high-power optical fibre amplifiers. This novel ability to control all the properties of light enables the generation of optical beams that were only theoretical ideas but never previously implemented experimentally. This advanced technology can potentially open new ways in which objects can be probed using light. Expected outcomes include the creation of an optical platform that the optical community at large may utilise for their specific applications. Besides the intellectual property benefits of such optical devices directly, this project should bridge the gap between the developed knowledge and commercial opportunities.Read moreRead less
Control of light in space and time in multimode optical fibres. This project aims to create devices to measure and manipulate the spatial and temporal properties of light. The ability to control or measure the spatial and/or temporal properties of light is a fundamental feature of many applications, including biomedical imaging, astronomy, telecommunications, high-power lasers and quantum computing. This project will develop five prototype systems to control the spatiotemporal properties of ligh ....Control of light in space and time in multimode optical fibres. This project aims to create devices to measure and manipulate the spatial and temporal properties of light. The ability to control or measure the spatial and/or temporal properties of light is a fundamental feature of many applications, including biomedical imaging, astronomy, telecommunications, high-power lasers and quantum computing. This project will develop five prototype systems to control the spatiotemporal properties of light in ways that were previously not possible. This would affect fundamental and applied applications where the inability to sufficiently control light’s spatial and/or temporal properties is an impediment. Examples include imaging deep into ‘opaque’ objects such as human skin or brain, high-power lasers for material processing and manufacturing, optical telecommunications and quantum computation.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL210100099
Funder
Australian Research Council
Funding Amount
$3,401,828.00
Summary
The Intelligent Microscope - novel optical imaging at depth. While optical methods for imaging are used extensively, achieving wide-field imaging through scattering media with high resolution and depth is a major challenge, due mainly to the limited penetration depth of light. This proposal aims to transform wide-field optical imaging through a new ‘intelligent’ microscopy able to capture 3D volumetric images. Innovations in shaping light in both space and time will be combined in a holistic wa ....The Intelligent Microscope - novel optical imaging at depth. While optical methods for imaging are used extensively, achieving wide-field imaging through scattering media with high resolution and depth is a major challenge, due mainly to the limited penetration depth of light. This proposal aims to transform wide-field optical imaging through a new ‘intelligent’ microscopy able to capture 3D volumetric images. Innovations in shaping light in both space and time will be combined in a holistic way with computational analysis to extract images from deep within the sample at extraordinary levels of detail. Major benefits of the research range from next-generation tools for enhanced discovery of biological and physical materials, to new Australian start-ups for new imaging and microscopy devices.Read moreRead less
Unlocking the ultraviolet. This project will develop a new class of ultra-short-pulse and broadly tunable laser with performance in the ultraviolet that is unobtainable from current infrared-based laser technologies. Our invention will unlock the elusive ultraviolet part of the spectrum to allow new discoveries in fundamental science and to drive twenty-first-century technologies.