Diamond Voltage Microscopy: A new tool for neuroscience. This project aims to develop an optoelectronic voltage imaging microscope that can capture the sub-cellular electrical dynamics of neuronal networks. This will be achieved by leveraging the team’s technological breakthrough in the production of near-surface fluorescent defects in semiconducting diamond, which can optically detect local changes in electric potential. The expected outcomes of the project are a new microscopy modality and exp ....Diamond Voltage Microscopy: A new tool for neuroscience. This project aims to develop an optoelectronic voltage imaging microscope that can capture the sub-cellular electrical dynamics of neuronal networks. This will be achieved by leveraging the team’s technological breakthrough in the production of near-surface fluorescent defects in semiconducting diamond, which can optically detect local changes in electric potential. The expected outcomes of the project are a new microscopy modality and experimental framework which enables in vitro electrophysiological stimulation and recording at network scale and with single-synapse resolution. This will provide a much-needed tool to understand mechanisms underlying learning, memory formation and recall, and cognitive decline.Read moreRead less
Dynamic multi-modal x-ray imaging. This project aims to create sensitive new methods of x-ray imaging that capture multiple image modalities with a single snapshot. Conventional x-ray imaging is widely used in a range of industries, but captures only a fraction of the rich information that is available in the x-ray wavefield. This project expects to extract additional image modalities to reveal x-ray-transparent features, and detect microscopic textures. By combining these capabilities with the ....Dynamic multi-modal x-ray imaging. This project aims to create sensitive new methods of x-ray imaging that capture multiple image modalities with a single snapshot. Conventional x-ray imaging is widely used in a range of industries, but captures only a fraction of the rich information that is available in the x-ray wavefield. This project expects to extract additional image modalities to reveal x-ray-transparent features, and detect microscopic textures. By combining these capabilities with the ability to capture images of a moving sample, this project will enable innovative biomedical and materials research studies, and develop new imaging technologies for use in security, hospitals and manufacturing. New methods of x-ray imaging will have wide-ranging benefits for society, the economy and healthcare.Read moreRead less
Nature’s advanced optical materials and their role in thermal management. This project aims to discover the nano-structural properties of beetles than enable effective management of solar and thermal radiation in different environments. A further aim is to reveal how these composite biological materials combine thermal control with desirable mechanical properties, such as strength and flexibility. Passive control of radiative energy is critical for both animal survival and for the design of many ....Nature’s advanced optical materials and their role in thermal management. This project aims to discover the nano-structural properties of beetles than enable effective management of solar and thermal radiation in different environments. A further aim is to reveal how these composite biological materials combine thermal control with desirable mechanical properties, such as strength and flexibility. Passive control of radiative energy is critical for both animal survival and for the design of many manufactured materials, particularly in a warming world. This interdisciplinary project will provide new knowledge of the different ways that biological materials mediate radiative energy exchange with the environment. This knowledge is essential for the design of bioinspired, energy-efficient, multi-functional materials.Read moreRead less
High-brightness wavelength tuneable lasers for quantum science. This project aims to establish the capability to manufacture application-specific semiconductor lasers. The project will use existing facilities in Australia to enhance our world-leading quantum science research, and establish a viable export-dominated high-tech manufacturing business. Semiconductor lasers are a critical enabling technology for many scientific applications, particularly for quantum science including quantum computin ....High-brightness wavelength tuneable lasers for quantum science. This project aims to establish the capability to manufacture application-specific semiconductor lasers. The project will use existing facilities in Australia to enhance our world-leading quantum science research, and establish a viable export-dominated high-tech manufacturing business. Semiconductor lasers are a critical enabling technology for many scientific applications, particularly for quantum science including quantum computing and quantum sensing. This project is expected to enable the establishment of a high-tech manufacturing capability to support Australia's leading role in quantum science, and expand our scientific instrumentation exports to new and rapidly developing applications such as magnetic sensing and imaging at nanoscale, quantum communication and computation.Read moreRead less
ARC Centre of Excellence in Optical Microcombs for Breakthrough Science. ARC Centre of Excellence in Optical Microcombs for Breakthrough Science. This Centre aims to explore the society wide transformations that will flow from optical frequency combs - thousands of highly pure light signals precisely spaced across the entire optical spectrum - by leveraging and building upon the latest breakthroughs in physics, materials science and nanofabrication. It expects to generate a wide new base of know ....ARC Centre of Excellence in Optical Microcombs for Breakthrough Science. ARC Centre of Excellence in Optical Microcombs for Breakthrough Science. This Centre aims to explore the society wide transformations that will flow from optical frequency combs - thousands of highly pure light signals precisely spaced across the entire optical spectrum - by leveraging and building upon the latest breakthroughs in physics, materials science and nanofabrication. It expects to generate a wide new base of knowledge in fields as diverse as astronomy, spectroscopy, chemical sensors, and precision measurement. Expected outcomes include the capability to realise complete comb systems on a chip the size of a fingernail, tailored to specific applications, with significant benefits spanning from imaging live cells to autonomous vehicles, satellite communications, and the search for exoplanets.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200101061
Funder
Australian Research Council
Funding Amount
$424,848.00
Summary
Single particle imaging: x-ray imaging of individual dynamic biomolecules. X-ray lasers produce powerful ultra-short pulses of light that can take temporal snap shots of small radiation-sensitive biological complexes. Thanks to superconducting technology, the next generation of x-ray lasers will be able to produce x-ray pulses at greater rates than ever before. But because of the sheer number of possible molecular configurations, these molecular movies will have only a small amount of data per f ....Single particle imaging: x-ray imaging of individual dynamic biomolecules. X-ray lasers produce powerful ultra-short pulses of light that can take temporal snap shots of small radiation-sensitive biological complexes. Thanks to superconducting technology, the next generation of x-ray lasers will be able to produce x-ray pulses at greater rates than ever before. But because of the sheer number of possible molecular configurations, these molecular movies will have only a small amount of data per frame, posing an enormous challenge for current imaging methods. I aim to meet this challenge by developing an innovative multi-conformational image reconstruction algorithm. This will provide a new window into the molecular dynamics of biological systems, the building blocks of life, and enable rational drug design.Read moreRead less
NanoMslide: plasmon-enhanced ptychographic phase microscopy. This proposal aims to combine recent advances in metamaterials and quantitative phase imaging to probe the near-surface refractive index properties of cells and tissues. The proposed technique delivers orders of magnitude improvement in terms of sensitivity over conventional phase contrast microscopy and will be used to provide new insights into the molecular basis for disease. This project will result in a new approach to stain-free, ....NanoMslide: plasmon-enhanced ptychographic phase microscopy. This proposal aims to combine recent advances in metamaterials and quantitative phase imaging to probe the near-surface refractive index properties of cells and tissues. The proposed technique delivers orders of magnitude improvement in terms of sensitivity over conventional phase contrast microscopy and will be used to provide new insights into the molecular basis for disease. This project will result in a new approach to stain-free, label free, tissue characterisation that will benefit a diverse range of applications in biological imaging and aid in the development of this nanotechnology platform into a long-term, sustainable business for Australia.Read moreRead less
Probing nanoscale disorder in 3D with x-ray free-electron lasers. This project aims to reveal the 3D nanostructure of disordered matter with x-rays for the first time. Existing x-ray scattering techniques for disordered structures currently provide limited, one-dimensional information only. The expected outcomes of the project include an enhanced new capability for the Australian Synchrotron and international x-ray laser facilities, and new insights into the microscopic origins of the properties ....Probing nanoscale disorder in 3D with x-ray free-electron lasers. This project aims to reveal the 3D nanostructure of disordered matter with x-rays for the first time. Existing x-ray scattering techniques for disordered structures currently provide limited, one-dimensional information only. The expected outcomes of the project include an enhanced new capability for the Australian Synchrotron and international x-ray laser facilities, and new insights into the microscopic origins of the properties of liquids and biological membranes. This should benefit research areas that use x-ray scattering to probe the nanostructure of materials for diverse applications such as nanotechnology, fuel cells and drug design.Read moreRead less
Agile synthesizers for quantum computing, simulation and sensing. The project aims to develop breakthrough technology for generating the complex radio and microwave pulses that underpin the revolution in quantum computing and quantum sensing. Quantum technologies are rapidly emerging from laboratory to real-world applications including neural imaging, defence surveillance, and mining exploration, but further advances require increased precision and flexibility in controlling the quantum states ....Agile synthesizers for quantum computing, simulation and sensing. The project aims to develop breakthrough technology for generating the complex radio and microwave pulses that underpin the revolution in quantum computing and quantum sensing. Quantum technologies are rapidly emerging from laboratory to real-world applications including neural imaging, defence surveillance, and mining exploration, but further advances require increased precision and flexibility in controlling the quantum states at the heart of these new capabilities. Our innovative and more flexible approach to signal generation requires a fraction of the size, weight, power and cost of conventional approaches, enabling the translation of quantum technology to commercial practicality.Read moreRead less