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Real-time Surveillance For The Early Detection Of E-health Related Adverse Events
Funder
National Health and Medical Research Council
Funding Amount
$311,860.00
Summary
Health care delivery has become increasingly dependent on information technology. There is growing concern about the risk of harm caused by e-health technology. Current methods for error detection are minimal, and healthcare software remains largely unregulated. This research aims to develop innovative surveillance technologies to provide real-time monitoring and to facilitate early detection of e-health generated adverse events, as a critical step to improve the safety of e-health technology.
Enhancing Quality In Primary Health Care Services Through Better Use Of Data And Information Systems
Funder
National Health and Medical Research Council
Funding Amount
$143,758.00
Summary
The performance of PHC services has increasingly been scrutinized due to the rise in prevalence of chronic diseases, growing demand for care, rising health care costs, and evidence of unexplained variations in clinical practice. The use of performance monitoring frameworks has increased and it is anticipated this process will become a regular activity. A key element to ensuring the successful engagement in performance monitoring activities is the effective management of information systems.
Brain Training In Osteoarthritis - Does It Decrease Pain?
Funder
National Health and Medical Research Council
Funding Amount
$299,564.00
Summary
In people with osteoarthritis (OA), the amount of pain is often not related to the amount of joint damage seen on x-ray. This suggests that there are other processes contributing to their pain. Recently, the role of the brain in contributing to chronic pain has been investigated. This project aims to determine what parts of the brain are affected in people with OA. It also aims to develop new treatments that target these brain areas and determine if these brain-training treatments decrease pain.
System Biology Approaches To Uncovering Non-coding RNAs' Roles In Characterising Cancer Subtypes
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
I aim to investigate non-coding RNAs (ncRNAs)’ roles in cancer development, and how they characterise cancer subtypes. The outcomes of the proposed research are twofold: computational methods to stratify tumor subtypes and computational methods to identify groups of ncRNAs acting as drivers for each cancer subtype. The research outcomes will enable prediction of new patients’ cancer subtypes and contribute to the design of efficient treatment therapies.
“Killer T cells” are specialised cells that help control viral infection. T cells recognize virus via proteins called “T cell receptors” (TCR). TCR are incredibly diverse, allowing us to recognise many different viruses. Recent advances in technology allow us to look at TCR and the genes encoding them, however their complexity makes that data difficult to interpret. I will use mathematical and statistical approaches to analyse and model this data to better understand immune recognition.
Titanium Implants With Dual Micro- And Nano-Scale Topography For Electrically Stimulated Osteogenic And Antibacterial Functions
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
The long-term success of titanium implants in high-risk patients (especially diabetics) is compromised and the current project aims to address this by developing nano-engineered therapeutic titanium implants. With appropriate multi-scale roughness, enhanced bioactivity, local antibiotic release and electrical stimulation to further enhance these features, the project aims at patient outcomes, while allowing easy integration into the current implant market.
Exploring The Role Of Matrix Metalloproteinase 12 (MMP12) In Macrophages During Bacterial Infection
Funder
National Health and Medical Research Council
Funding Amount
$384,768.00
Summary
Golden staph infections incur a high morbidity and mortality in Australia costing AUD150M p.a. One of our strongest lines of defense, white blood cells, are known to secrete an extracellular enzyme, matrix metalloproteinase 12 (MMP12). MMP12 digests and modifies functions of other proteins. We will utilize unbiased large-scale “omics” technologies to identify genes responsible for infection dampening due to MMP12 function. This will allow for better informed drug design to treat superbugs.
The fundamental problem with pain is that it cannot be seen. We can see injury, but pain and injury are quite often not related. Brain imaging has demonstrated consistent patterns of activity when we feel pain, and long-term changes that happen in chronic, i.e. persistent, painful disorders. This project will use the best technology available to investigate the basics of how our brains perceive pain, and to shed light on some of the brain mechanisms that underpin chronic pain.
Optimising Value And Equity In Access To Prescribed Medicines
Funder
National Health and Medical Research Council
Funding Amount
$371,052.00
Summary
The strong opposition to the Federal government’s proposed increase in out-of-pocket healthcare costs in the 2014 budget demonstrates the significance of value-for-money healthcare to the Australian public. Using information from Canada and Australia, this study will help patients, regardless of socioeconomic status, to access the medicines they need in a way that is affordable for individuals and governments, resulting in wise and fair medicine use within the Australian healthcare system.