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Mechanisms Of Weight And Adipose Loss Following Inhibition Of The Renin-angiotensin System
Funder
National Health and Medical Research Council
Funding Amount
$330,722.00
Summary
As an energy homeostasis researcher, with a particular interest in ingestive behaviour, I plan to examine the role the renin-angiotensin system in energy balance and obesity. I will achieve this by spending two years learning new techniques and conducting research in one of the top energy balance labs in the world, headed by Professor Stephen Woods (University of Cincinnati). I will then return to Australia to implement the techniques I have learned and extend this research.
Docosahexaenic Acid (DHA) From Dairy. How Dietary Omega-3 Fats From Dairy Can Increase DHA Levels To Improve
Funder
National Health and Medical Research Council
Funding Amount
$427,887.00
Summary
A high level of the omega-3 fat DHA in the blood is related to good health and has benefits on neural development in breastfed infants. Infant formulas have been enriched with preformed DHA but are expensive and may be environmentally unsustainable. Dairy contains DPA, a direct precursor of DHA. I aim to identify DPA-rich dairy sources, produce a safe and inexpensive nutritional powder and validate its efficacy in an animal model and a human infant clinical trial. Based on research outcomes, thi ....A high level of the omega-3 fat DHA in the blood is related to good health and has benefits on neural development in breastfed infants. Infant formulas have been enriched with preformed DHA but are expensive and may be environmentally unsustainable. Dairy contains DPA, a direct precursor of DHA. I aim to identify DPA-rich dairy sources, produce a safe and inexpensive nutritional powder and validate its efficacy in an animal model and a human infant clinical trial. Based on research outcomes, this powder will be safe and inexpensive and have the potential to be marketed as a Infant Formula Supplement.Read moreRead less
Lipotoxicity, Mitochondrial Dysfunction And The Pathogenesis Of Heart Failure
Funder
National Health and Medical Research Council
Funding Amount
$454,358.00
Summary
Heart failure (HF) is the most common basis for hospitalisation or cardiac death despite improved treatment options. Impaired energy generation within heart muscle is important in causing HF, but little is known about this process. I plan to investigate the effects of fatty acid overload, as occurs in obesity and/or diabetics, on cardiac energy generation. Then, I'll explore the benefits of limiting fatty acids during heart surgery, in order to help in understanding the causes of HF, and the ben ....Heart failure (HF) is the most common basis for hospitalisation or cardiac death despite improved treatment options. Impaired energy generation within heart muscle is important in causing HF, but little is known about this process. I plan to investigate the effects of fatty acid overload, as occurs in obesity and/or diabetics, on cardiac energy generation. Then, I'll explore the benefits of limiting fatty acids during heart surgery, in order to help in understanding the causes of HF, and the benefits of new, energy-conserving treatmentsRead moreRead less
Emu Oil And Protection From Experimentally-induced Ulcerative Colitis And Crohn's Disease
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
The inflammatory bowel diseases (IBD), encompassing ulcerative colitis and Crohn’s disease, are chronic intestinal inflammatory disorders of unknown cause. Current treatments for IBD are variably effective highlighting the need for improved therapeutic approaches. Emu Oil is reported to exert potent anti-inflammatory and antioxidant effects. Using well established experimental models, we seek to determine the potential efficacy and underlying mechanism of Emu Oil action in acute and chronic IBD.