The Early Life Origins Of Impaired Testicular Function: A Prospective Cohort Study
Funder
National Health and Medical Research Council
Funding Amount
$623,277.00
Summary
There is a widespread public perception that sperm counts are diminishing. This theory can only be tested by using a representative sample of young men, rather than biased populations (such as men presenting as sperm donors). We have the unique opportunity to test this theory, and to determine any early life events which may lead to reduced sperm counts, such as being growth restricted at birth, exposed to high levels of maternal oestrogens or smoking or being overweight in adolescence.
Exposure To Diesel Exhaust And Lung Cancer Risk In Australia
Funder
National Health and Medical Research Council
Funding Amount
$581,519.00
Summary
Exposure to diesel exhaust increases the risk of lung cancer. One in five Australians is exposed to diesel exhaust in the workplace. This project will provide an exposure-response relation between diesel exhaust and lung cancer based on Australia-specific data. We will also estimate the number of lung cancer cases due to diesel exhaust exposure in Australia. We will do this by studying all miners in WA in the last 15 years, by linking several databases that are available in WA.
Quantitiative Assessment Of Solar UV Exposure For Vitamin D Synthesis In Australian Adults
Funder
National Health and Medical Research Council
Funding Amount
$1,162,536.00
Summary
This research program will add significantly to our current scientific understanding of the dual health outcomes of UV exposure (Vitamin D and skin cancer) . This project is in line with Australia's R and D Priorities, in that it will result in direct and indirect social and economic benefits to Australia by applying the scientific knowledge gained through this research to develop public health initiatives to improve some of Australia's most significant and costly health problems.
Testis To Ovary: Hormonal Control Of Differentiation
Funder
National Health and Medical Research Council
Funding Amount
$803,379.00
Summary
We know very little of the genes that control development of the ovary in female fetuses; most study has focused on the formation of the testis in males. We will use a novel experimental model, a marsupial, where by hormonal treatment of developing males we can switch off testis formation and activate the ovarian pathway. These studies will potentially shed new light on the causes of reproductive diseases including ovarian cancer, as well as clarifying the basic biological processes that guide f ....We know very little of the genes that control development of the ovary in female fetuses; most study has focused on the formation of the testis in males. We will use a novel experimental model, a marsupial, where by hormonal treatment of developing males we can switch off testis formation and activate the ovarian pathway. These studies will potentially shed new light on the causes of reproductive diseases including ovarian cancer, as well as clarifying the basic biological processes that guide formation of the ovary.Read moreRead less