Final frontier in computational modelling of movement. This project aims to create the computational models and methods needed to advance current understanding of musculoskeletal function during movement. Humans must maintain their capacity to move in order to maintain quality-of-life. Predictive modelling is potentially the most powerful approach for understanding musculoskeletal function during movement. Current computational methods are too slow and unreliable to deliver predictive simulation ....Final frontier in computational modelling of movement. This project aims to create the computational models and methods needed to advance current understanding of musculoskeletal function during movement. Humans must maintain their capacity to move in order to maintain quality-of-life. Predictive modelling is potentially the most powerful approach for understanding musculoskeletal function during movement. Current computational methods are too slow and unreliable to deliver predictive simulations of movement using realistic models of muscle and joint anatomy. This project expects to create the next generation of methods and algorithms needed to enable predictive modelling of movement. Predictive simulations will provide new insights into how muscles stabilise and control movements of the spine, pelvis and lower limbs during daily activities such as walking.Read moreRead less
Measuring large deformation tissue mechanical behaviour in living humans. This project aims to develop new in vivo imaging methods to characterise the nonlinear mechanical behaviour of soft biological tissues, and use them to measure the properties of muscle, liver and adipose tissue in human subjects. Comprehensively characterising the mechanical properties of an individual person’s body tissues in vivo is a long-standing challenge in biomechanics and biomedical engineering. These new methods a ....Measuring large deformation tissue mechanical behaviour in living humans. This project aims to develop new in vivo imaging methods to characterise the nonlinear mechanical behaviour of soft biological tissues, and use them to measure the properties of muscle, liver and adipose tissue in human subjects. Comprehensively characterising the mechanical properties of an individual person’s body tissues in vivo is a long-standing challenge in biomechanics and biomedical engineering. These new methods aim to overcome major imitations of current biomechanical imaging methods, and make new measurements of the nonlinear mechanical properties of muscle, liver and adipose tissues. These techniques may be useful for future diagnostic, biomechanics and mechanobiology applications.Read moreRead less
Fundamental theoretical and experimental investigation of cartilage mechanics. Arthritis and chronic joint symptoms are one of the leading causes of disability in the community, yet a fundamental understanding of joint mechanics has yet to be realised. The aim of this project is to develop a new state-of-the-art mathematical model describing cartilage behaviour in humans. The model will explain how activities like walking maintain healthy cartilage by transferring growth factors through the tiss ....Fundamental theoretical and experimental investigation of cartilage mechanics. Arthritis and chronic joint symptoms are one of the leading causes of disability in the community, yet a fundamental understanding of joint mechanics has yet to be realised. The aim of this project is to develop a new state-of-the-art mathematical model describing cartilage behaviour in humans. The model will explain how activities like walking maintain healthy cartilage by transferring growth factors through the tissue, and quantitatively explain how wear is minimised in cartilage through weeping lubrication. This model will progress our understanding of cartilage mechanics in health and disease, and so help Australians age well and productively.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0454081
Funder
Australian Research Council
Funding Amount
$276,317.00
Summary
Innovative Assistive Technology for Severely Disabled People. Severe disability costs Australia $1 billion a year and affects about 50,000 people. These people have few options to enhance their independence. The purpose of this grant is to purchase six equipment systems to support high quality research in this field. The new facility builds upon substantial national and international research strengths and collaborations to develop a world lead in assistive technology. This will yield a new gene ....Innovative Assistive Technology for Severely Disabled People. Severe disability costs Australia $1 billion a year and affects about 50,000 people. These people have few options to enhance their independence. The purpose of this grant is to purchase six equipment systems to support high quality research in this field. The new facility builds upon substantial national and international research strengths and collaborations to develop a world lead in assistive technology. This will yield a new generation of innovative medical devices that give the disabled people more independence, mobility and control over their lives, and form the basis of a niche export industry.Read moreRead less
Inhomogeneous tissue conductivity influence on the forward and inverse electroencephalogram problems in realistic head models. The brain dysfunction indicators have been extremely difficult to obtain, largely because many disorders of higher brain function reflect abnormalities of brain function rather than apparent brain structure. The neuronal generator localization and identification in this project will provide complementary information about source and timing of neural activities sub-servin ....Inhomogeneous tissue conductivity influence on the forward and inverse electroencephalogram problems in realistic head models. The brain dysfunction indicators have been extremely difficult to obtain, largely because many disorders of higher brain function reflect abnormalities of brain function rather than apparent brain structure. The neuronal generator localization and identification in this project will provide complementary information about source and timing of neural activities sub-serving higher brain function and form sequences of spatial-temporal brain activity image. That will enable the information from MRI, which has a good spatial but poor temporal resolution, and the information from EEG, which has a high temporal resolution on the scalp, to be combined to provide clinical psychologists and brain researchers a more efficient diagnostic tool.Read moreRead less
New open MRI Technology for Kinematic Orthopaedic Imaging. This application intends to significantly enhance Open MRI as applied to dynamic joint imaging by technological and methodological innovation. Expected outcomes include better technology for the imaging of joints under loaded movement and consequently, improved understanding of joint function and disease. This technology will provide unique ability in Australia and brings together highly skilled groups in Biomedical Engineering, medical ....New open MRI Technology for Kinematic Orthopaedic Imaging. This application intends to significantly enhance Open MRI as applied to dynamic joint imaging by technological and methodological innovation. Expected outcomes include better technology for the imaging of joints under loaded movement and consequently, improved understanding of joint function and disease. This technology will provide unique ability in Australia and brings together highly skilled groups in Biomedical Engineering, medical equipment manufacturing and design and musculo-skeletal imaging.Read moreRead less
Cardiac electrographic modelling and analysis. The outcomes of this project will improve the accuracy with which abnormal conduction pathways in the heart are found and will also use chaotic modelling tools to better predict the need and outcomes of patients with life threatening arrhythmias.
Quantitative micro-computed tomography for mechanobiological measurement. This project aims to investigate novel measurement approaches for complex cartilage and joint systems by utilising engineering and software design, imaging physics and musculoskeletal biology. Accurate measurement of these living biological systems in action expects to generate new knowledge and a fundamental understanding of their mechanobiological processes. This project will enhance understanding of this complex system ....Quantitative micro-computed tomography for mechanobiological measurement. This project aims to investigate novel measurement approaches for complex cartilage and joint systems by utilising engineering and software design, imaging physics and musculoskeletal biology. Accurate measurement of these living biological systems in action expects to generate new knowledge and a fundamental understanding of their mechanobiological processes. This project will enhance understanding of this complex system and facilitate our capacity to innovate functional solutions in biomedical engineering and biosciences.Read moreRead less
Biomechanical model-based algorithms for computational radiology of the brain. The proposed research will develop computational framework, which will allow matching high quality pre-operative brain images with lower resolution images taken during neurosurgery. The success of this work will greatly improve effectiveness of brain tumour removal, and therefore improve clinical outcomes. The proposed work will provide enabling technology for other areas of computer aided medicine, such as virtual re ....Biomechanical model-based algorithms for computational radiology of the brain. The proposed research will develop computational framework, which will allow matching high quality pre-operative brain images with lower resolution images taken during neurosurgery. The success of this work will greatly improve effectiveness of brain tumour removal, and therefore improve clinical outcomes. The proposed work will provide enabling technology for other areas of computer aided medicine, such as virtual reality operation planning systems with realistic force and tactile feedback, control systems of neurosurgical robots with tissue deformation prediction module, etc.Read moreRead less
Influence of electromagnetic emissions from mobile phones on nervous function in the human brain and heart. This research will investigate the influence of mobile phone electromagnetic exposures on the nervous function of the human brain and heart. Brain activity will be monitored by EEG recordings, and heart function will be measured by blood pressure and ECG. As far as possible the methodologies employed will be consistent with previous reported studies in order to allow comparisons, and use ....Influence of electromagnetic emissions from mobile phones on nervous function in the human brain and heart. This research will investigate the influence of mobile phone electromagnetic exposures on the nervous function of the human brain and heart. Brain activity will be monitored by EEG recordings, and heart function will be measured by blood pressure and ECG. As far as possible the methodologies employed will be consistent with previous reported studies in order to allow comparisons, and use standardised quantifiable metrics so that the biological significance of the data can be meaningfully interpreted. The outcomes of this project will address uncertainties in the present data which are of concern to national and international regulatory and health agencies.Read moreRead less