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Improving Translation Of Intensity And Quality Of Upper Limb Rehabilitation Provided By Occupational Therapists To Children With Unilateral Cerebral Palsy: A Cluster Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$225,539.00
Summary
This study aims to increase occupational therapist's use of best available evidence of intensive upper limb therapy for children with unilateral cerebral palsy. The study will determine in a cluster randomised trial whether a multifaceted implementation program comprising: (a) audit & feedback, (b) identifying barriers to implementing best practice evidence, and (c) targeted interactive training is more effective than a single faceted program (audit & feedback alone) to increase evidence uptake.
Cerebral palsy is the most common physical disability in children. Rehabilitation focuses on improving hand use to enhance daily care, access to education and vocational aspirations. This research aims to change the type of rehabilitation therapists use to treat hand and arm problems and use more current training approaches which have been shown to improve hand and arm skills.
Improving Early Rehabilitation For Patients With Acute Stroke
Funder
National Health and Medical Research Council
Funding Amount
$149,782.00
Summary
The Australian stroke guidelines recommend that intensive rehabilitation (60 mins practice/day) should commence as soon as possible after stroke onset, however this rarely occurs in clinical practice. The proposed research will explore this evidence-practice gap, and develop a protocol to improve early rehabilitation for patients hospitalised with acute stroke. The early rehabilitation protocol will then be tested in four acute stroke units for safety and feasibility.
Next-generation Glioblastoma Multiforme Therapies Based On Multistage Delivery Nanovectors
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
Nanomedicine provides novel therapies with enhanced treatment success and reduced side effects, which improve the patient’s quality of life. Drug delivery systems that are able to treat highly drug-resistant tumours such as glioblastoma multiforme (GBM) are a key target for nanomedicine-based therapies. We will investigate a new GBM treatment by developing a multistage delivery nanovector to selectively carry and release a combination of chemical and physical therapeutics.
Understanding Relapse In Posttraumatic Stress Disorder: An Investigation Of Return Of Fear.
Funder
National Health and Medical Research Council
Funding Amount
$255,014.00
Summary
Posttraumatic Stress Disorder (PTSD) is common and results in significant impairment. There are effective psychological treatments for PTSD, yet relapse following treatment remains high. The proposed research will involve a series of experiments and observational studies to better understand the process that lead to relapse in patients receiving treatment for PTSD. The findings of these studies will assist in modifying treatment to ensure that symptom gains are maintained following treatment.
Improving The Therapeutic Use Of Anti-infective Agents: Application Of Pharmacometrics For Rational Dosing Regimen Design
Funder
National Health and Medical Research Council
Funding Amount
$313,390.00
Summary
There is no field of medicine in which the individualisation of medicines is more important than in infectious diseases – appropriate doses must be administered to maximise efficacy and to minimise side effects and the emergence of drug-resistance. This fellowship will use the emerging science of pharmacometrics to investigate factors contributing to the variability in response to anti-infective medications and to optimise dosing regimens for the best use of these drugs in clinical practice.
Identifying Mechanisms Of Resistance To Novel Hormonal Agents In Patients With Castrate-resistant Prostate Cancer
Funder
National Health and Medical Research Council
Funding Amount
$420,004.00
Summary
I am a medical oncologist focused on prostate cancer, a disease which kills over 3000 Australian men every year. Recent studies have shown that new hormone treatments help men with advanced prostate cancer live longer. Unfortunately, while these drugs are effective when first started, prostate cancers eventually become resistant to them and start growing again. By looking at why these drugs stop working, I hope to find better treatments for Australian men with advanced prostate cancer.