Optimising Pharmaceutical Care For People With Dementia In Acute Care Settings
Funder
National Health and Medical Research Council
Funding Amount
$719,637.00
Summary
Delivering appropriate acute care services for people with dementia is a major healthcare challenge in Australia. People with dementia do not receive appropriate care in hospitals and are more likely to experience worse clinical outcomes compared to people without dementia. This proposal will establish the first large-scale multi-centre cohort of inpatients with dementia, to systematically investigate the impact of hospitalisation on prescribing, clinical and patient-centred outcomes.
ELders AT Ease Program (ELATE): A Cluster Randomised Controlled Trial Of A Sustainable And Scalable Mental Health Service For Australian Residential Aged Care Facilities
Funder
National Health and Medical Research Council
Funding Amount
$999,551.00
Summary
Elders living in residential facilities suffer significant levels of depression or anxiety. This study examines an innovative program to improve mental health of residents living in such facilities. The program involves counselling, staff training and family support. The study uses a cluster randomised controlled trial of facilities to evaluate the impact of ELATE: Elders at Ease Program” on residents’ psychological wellbeing, staff knowledge, family carer stress and, health care costs.
Personalised Prognostic Tools For Early Psychosis Management (PRONIA)
Funder
National Health and Medical Research Council
Funding Amount
$401,739.00
Summary
Psychosis can be a devastating illness with harmful long-term consequences, such as chronic schizophrenia. To avoid distress, deterioration, and potential disability, we need more accurate tools to personalise treatment for individuals by understanding their prognosis. The PRONIA project will help to improve methods of predicting outcomes by working with our European colleagues to create a cybernetic prognostic system for psychosis that uses brain imaging, genetics, cognition, and clinical marke ....Psychosis can be a devastating illness with harmful long-term consequences, such as chronic schizophrenia. To avoid distress, deterioration, and potential disability, we need more accurate tools to personalise treatment for individuals by understanding their prognosis. The PRONIA project will help to improve methods of predicting outcomes by working with our European colleagues to create a cybernetic prognostic system for psychosis that uses brain imaging, genetics, cognition, and clinical markers.Read moreRead less
RARE-Bestpractices: Best Practices For Management Of Rare Diseases
Funder
National Health and Medical Research Council
Funding Amount
$640,231.00
Summary
Although by definition rare, over 8000 rare diseases affect approximately 1.2 million Australians. Patient care has suffered from fragmented approaches and lack of information available to health professionals. This project brings together major experts on rare diseases to improve the translation of scientific progress into tangible benefits for patients. The ultimate impact of this work will be the significant improvement of health outcomes and quality of life for rare disease patients and redu ....Although by definition rare, over 8000 rare diseases affect approximately 1.2 million Australians. Patient care has suffered from fragmented approaches and lack of information available to health professionals. This project brings together major experts on rare diseases to improve the translation of scientific progress into tangible benefits for patients. The ultimate impact of this work will be the significant improvement of health outcomes and quality of life for rare disease patients and reducing inequality in care.Read moreRead less
Multidimensional Assessment Of The Health Impacts Of Infrasound: Two Randomised Controlled Trials
Funder
National Health and Medical Research Council
Funding Amount
$1,943,934.00
Summary
The human health impact of infrasound that comes from wind turbines has not been well researched. We will assemble a team of researchers with a broad range of expertise to run a short term and longer term study to investigate whether exposure to infrasound causes health problems. The short term study will be lab based and run for three one week periods and the longer term study will be community based and run for six months. Sleep quality, balance, mood, cardiovascular health will be measured.
OzENTER-TBI_Australia-Europe NeuroTrauma Effectiveness Research In TBI Collaboration
Funder
National Health and Medical Research Council
Funding Amount
$368,823.00
Summary
The OzENTER-TBI project will advance the care of traumatic brain injury (TBI) patients. Researchers will collaborate with the European CENTER-TBI project to characterise and classify TBI. They will contribute to large data sets which will explore the differences between sites and countries on TBI outcomes. They will also investigate emerging technologies in TBI. It will have a profound impact on treatment, health care costs and ultimately quality of life for TBI patients worldwide.
Long-term Outcome Of Individuals Who Had A First-episode Psychosis
Funder
National Health and Medical Research Council
Funding Amount
$1,344,905.00
Summary
The long-term illness course and outcomes of patients treated for first episode psychosis are poorly understood especially in terms of important domains such as social and vocational functioning, physical health, and quality of life. This treated cohort study of a sample of 786 patients, 15 years after their first episode of psychosis will be one of the longest and largest conducted to date. Results of the study will inform clinical practice and policy development.
Imaging And Chemical Biomarkers For Assessing The Effectiveness Of Therapy In The First European Investigator-driven Clinical Trial Investigating The Benefits Of Hypothermia In Ischaemic Stroke Patients
Funder
National Health and Medical Research Council
Funding Amount
$1,048,570.00
Summary
Hypothermia, entering phase III trial in Europe, has the potential to slow brain injury after stroke. It will allow existing thrombolytic therapies which restore critical brain blood flow to be used in many more patients than currently possible. However, hypothermia will soak up valuable resources if non-selectively applied to the ~15 million patients who have a stroke each year. We aim to identify biomarkers to test which patients will benefit most and permit the best resource allocation.
The Impact Of Befriending On Depression, Anxiety, Social Support And Loneliness In Older Adults Living In Residential Aged Care Facilities
Funder
National Health and Medical Research Council
Funding Amount
$661,872.00
Summary
About half of people living in residential aged care facilities may have significant depression symptoms. Many residents are socially isolated in RACFs even though they are in communal living, and social isolation is a contributor to depression. We propose a trial of befriending which is emotional and social support from trained volunteers. Volunteers will be trained using Beyondblue resources and a manual developed by the investigators.
The Interaction Between The Host And Pathogen Genetics In Susceptibility To Pulmonary Tuberculosis
Funder
National Health and Medical Research Council
Funding Amount
$390,294.00
Summary
People infected with the bacteria causing tuberculosis (TB) have different clinical fates. Some people remain well with dormant infections, some get lung disease and survive, others die. We are investigating the interplay between the human host and the bacteria causing disease by identifying genetic variants in both. This will enable us to determine what is important in the defence against this disease. Knowledge of the different TB disease processes is critical for future rational design of new ....People infected with the bacteria causing tuberculosis (TB) have different clinical fates. Some people remain well with dormant infections, some get lung disease and survive, others die. We are investigating the interplay between the human host and the bacteria causing disease by identifying genetic variants in both. This will enable us to determine what is important in the defence against this disease. Knowledge of the different TB disease processes is critical for future rational design of new TB vaccines and treatments.Read moreRead less