Improving The Design Of Pragmatic Clinical Trials In Children
Funder
National Health and Medical Research Council
Funding Amount
$128,224.00
Summary
Whilst clinical research is designed to investigate interventions that improve patient health, to date, patients (including children) and their families have had no say in deciding what health outcomes matter most to them. The voices of patients and their families must be heard and used to inform how studies are designed if we are to achieve an improved model of health care and health service delivery. We propose to investigate and provide recommendations as to how this is best achieved.
A Centre For Research Excellence In Cerebral Palsy (CRE-CP)
Funder
National Health and Medical Research Council
Funding Amount
$2,622,042.00
Summary
Cerebral palsy is the most common physical disability in childhood. Our objective is to bring about a radical improvement in the treatment of individuals with cerebral palsy, both children and adults, and to determine better ways to assist their families. Emphasis will be placed on early detection of health issues and rigorous evaluation of management options. We will train more researchers and ensure that all the knowledge generated is made available to families and health care professionals.
Does Placental Transfusion Prevent Death And Disability In Very Preterm Infants? Childhood Follow Up In The NHMRC Australian Placental Transfusion Study.
Funder
National Health and Medical Research Council
Funding Amount
$889,406.00
Summary
A million babies are born before 30 weeks gestation worldwide each year. Many die or face a lifetime of disability. Enhancing placental transfusion in these infants by deferred clamping of the umbilical cord (DCC) is a simple procedure that may reduce mortality and major disability in childhood. The Australian Placental Transfusion Study (APTS), the largest ever RCT of deferred clamping, will follow up 1200 children born preterm to evaluate if DCC has childhood benefits at 2 years age.
Febrile Seizures Following Vaccination In Children: How Common Are They And What Is The Long Term Clinical Outcome?
Funder
National Health and Medical Research Council
Funding Amount
$693,779.00
Summary
Seizures following vaccination cause concern for both parent and healthcare providers and in this important study we will measure the risk of febile seizures after vaccines and follow up children who have had a febrile seizure shortly after receiving a vaccine to assess their medical health and developmental outcome. In addition children will be tested to see if they carry one of the known genetic mutations that is asociated with the development of seizures as a potential cause for their seizure ....Seizures following vaccination cause concern for both parent and healthcare providers and in this important study we will measure the risk of febile seizures after vaccines and follow up children who have had a febrile seizure shortly after receiving a vaccine to assess their medical health and developmental outcome. In addition children will be tested to see if they carry one of the known genetic mutations that is asociated with the development of seizures as a potential cause for their seizure following vaccination.Read moreRead less
Evaluation Of The Incorporation Of WHO Guidelines Into Post-graduate Medical Curriculum; The Impact On Quality Of Care
Funder
National Health and Medical Research Council
Funding Amount
$130,704.00
Summary
There is abundant evidence that many patients do not receive medical treatments of proven effectiveness. This is even more apparent in developing countries. Strategies to improve use of proven treatments is needed. Our research aims to evaluate an educational program for doctors in Lao PDR, based on World Health Organisation guidelines for the care of sick children in hospitals, including the impact on the knowledge of doctors and on the quality of care in the hospitals in which they work.
IMPROVING HEALTH OUTCOMES IN CHILDREN SUFFERING MAJOR INJURY
Funder
National Health and Medical Research Council
Funding Amount
$521,876.00
Summary
In Australia injury is the leading cause of childhood morbidity - more than cancer and heart disease combined. Yet, there has been no published comprehensive analysis of the processes of care or the systems for treating severe paediatric injury in Australia. Partnered with government and consumers, this study will generate evidence and implement interventions to provide better care for severely injured children and their families
The Burden Of Late Preterm Birth On Brain Development And 2 Year Outcomes – A Prospective, Longitudinal Cohort Study
Funder
National Health and Medical Research Council
Funding Amount
$838,690.00
Summary
80% of preterm babies are born from 32-36 weeks’ gestation, and are late preterm (LPT). LPT children have more learning problems, but why this occurs is unknown. This study aims to understand the effect of LPT birth on brain development. We will do brain scans at term and assess development at 2 years of age of 200 LPT and 200 full-term children. We expect LPT babies will have subtle alterations in brain development compared with term controls which will be associated with delayed development.
A Randomised Controlled Trial To Evaluate Early Intervention In Chronic Cough In Indigenous Children
Funder
National Health and Medical Research Council
Funding Amount
$1,432,252.00
Summary
This study aims to determine whether a validated evidence-based cough algorithm initiated at the development of chronic cough, defined as >4 weeks duration, following an acute respiratory illness (ARI) improves clinical outcomes in urban, rural and remote Indigenous children compared to standard care. The study will also examine the predictors of chronic cough and cough outcomes in these children as well as the cost-effectivess of the intervention.
Does Bovine Lactoferrin Prevent Death Or Disability In Very Low Birthweight Infants? Childhood Follow Up In The NHMRC LIFT Study
Funder
National Health and Medical Research Council
Funding Amount
$1,474,012.00
Summary
Our international consortium of investigators proposes to undertake follow up in survivors among 1,500 very low birth weight preterm infants enrolled in the NHMRC Lactoferrin Infant Feeding Trial, which is designed to evaluate whether low-cost oral lactoferrin supplementation reduces death and disability in early childhood.