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Burden Of Rheumatic Heart Disease (RHD) And Impact Of Prevention Strategies: Comprehensive Evidence To Drive The RHD Endgame
Funder
National Health and Medical Research Council
Funding Amount
$960,655.00
Summary
Rheumatic heart disease is chronic damage to the heart valves caused by repeated bouts of acute rheumatic fever. Both are preventable, yet rates among Indigenous Australians are of the highest recorded. We propose to undertake the first multi-jurisdictional study of these conditions to determine trends in occurrence and evaluate the impact of existing interventions in Australia. Findings will be used to inform the development of a roadmap to remove RHD as a public health problem in Australia.
Clinical And Psychosocial Changes Over Late Childhood And Adolescence And Early Life Determinants Of Long Term Clinical Outcomes In Cystic Fibrosis
Funder
National Health and Medical Research Council
Funding Amount
$1,135,570.00
Summary
Cystic fibrosis is the most common life shortening inherited disease in Caucasians. Lung damage starts in infancy and lung function falls most rapidly in adolescence although why and how this happens and early life determinants are not known. This study takes advantage of a previous study that monitored young children from 3 months to 5 years of life and follows them closely through early adolescence to investigate the protective and risk factors for falling lung function.
ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial ....ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial concepts into statistical analysis and modelling, powerful visualisation of information, and the building spatial decision support systems, to provide an improved evidence base and better informed decision-making to address the significant challenges facing Australia's people and its places.Read moreRead less
Regulation Of Key Pathways Causing Peri-implant Bone Loss.
Funder
National Health and Medical Research Council
Funding Amount
$403,639.00
Summary
The failure of bone prostheses is becoming a major health problem in our aging population. Despite the impressive success of joint replacement surgery, a significant number of arthroplasties fail. It is now apparent that most implants fail due to bone loss around them which leads to loosening. This project aims to obtain a better understanding of the causes of implant failure and find ways to extend the life of these implants .
THE PEOPLE ENGAGE IN POLITICAL LIFE: THE NINETEENTH CENTURY AMERICAN STORY. Using unique archives of individual level political information, this study explores the idea of political identities and the ways ordinary citizens in nineteenth century America established their place in political life. Nine carefully chosen case studies allow examination of political participation and partisanship in settings traditional and modern, urban and rural. The project asks how, and whether, a democratic theo ....THE PEOPLE ENGAGE IN POLITICAL LIFE: THE NINETEENTH CENTURY AMERICAN STORY. Using unique archives of individual level political information, this study explores the idea of political identities and the ways ordinary citizens in nineteenth century America established their place in political life. Nine carefully chosen case studies allow examination of political participation and partisanship in settings traditional and modern, urban and rural. The project asks how, and whether, a democratic theory arising from a politics of rural localism retained meaning for citizens in very different social settings. Understanding how political identities were created in the past may help us identify ways to increase the saliency of politics in ordinary lives today.
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Scholarly Editions of James Hogg's The Three Perils of Man and Edinburgh periodical writings and Walter Scott's miscellaneous short stories. This project will add significantly to scholarly knowledge of James Hogg, now recognised as one of the most important nineteenth century Scottish writers, and of his better known contemporary Walter Scott. The exciting and very recent discovery of the original manuscript of Hogg's most ambitious novel, The Three Perils of Man, the inclusion of Scott's final ....Scholarly Editions of James Hogg's The Three Perils of Man and Edinburgh periodical writings and Walter Scott's miscellaneous short stories. This project will add significantly to scholarly knowledge of James Hogg, now recognised as one of the most important nineteenth century Scottish writers, and of his better known contemporary Walter Scott. The exciting and very recent discovery of the original manuscript of Hogg's most ambitious novel, The Three Perils of Man, the inclusion of Scott's final, unpublished novella and the addition of a volume of Hogg's periodical writings have meant a major expansion of work already underway. The project will enhance the international reputation of Australian scholars through their participation in producing internationally recognised editions of important literary texts.Read moreRead less
Clinical Outcomes, Safety And Incremental Cost Effectiveness Of Multi-level Airway Surgery In Patients With Moderate-severe Obstructive Sleep Apnea (OSA) Who Have Failed Medical Management
Funder
National Health and Medical Research Council
Funding Amount
$652,794.00
Summary
Obstructive sleep apnoea (OSA) is a serious medical disorder with a high public health cost. OSA can be effectively treated but poor treatment compliance is a major clinical problem. As a consequence many OSA patients remain untreated, with significant implications for their long term health. New effective and safe therapies are needed. We believe that we will demonstrate a relatively straightforward, safe and effective surgical procedure for OSA after primary treatments fail. This will lead to ....Obstructive sleep apnoea (OSA) is a serious medical disorder with a high public health cost. OSA can be effectively treated but poor treatment compliance is a major clinical problem. As a consequence many OSA patients remain untreated, with significant implications for their long term health. New effective and safe therapies are needed. We believe that we will demonstrate a relatively straightforward, safe and effective surgical procedure for OSA after primary treatments fail. This will lead to improved patient outcomes.Read moreRead less
Impact Of Health Policy On The Delivery Of Dental Services And Child Oral Health Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$1,304,799.00
Summary
This project will study the use of dental services by children and adolescents in Australia and how use relates to oral health outcomes. Variation in the support for the use of private dentists and the organisation and delivery of school dental services will be compared both within and across all states and territories so as to inform policy discussions on how to best improve child oral health.
Cartoon Nation: Australian Editorial Cartooning - Past, Present, and Future. This landmark study aims to facilitate a new scholarly and public appreciation of Australian editorial cartooning: something often celebrated, but seldom studied seriously. At a moment when the art-form is transitioning, the study will elucidate its enduring democratic and cultural significance, revealing diverse stories told through cartoons. Expected project outcomes include: pioneering new scholarship; the enhancemen ....Cartoon Nation: Australian Editorial Cartooning - Past, Present, and Future. This landmark study aims to facilitate a new scholarly and public appreciation of Australian editorial cartooning: something often celebrated, but seldom studied seriously. At a moment when the art-form is transitioning, the study will elucidate its enduring democratic and cultural significance, revealing diverse stories told through cartoons. Expected project outcomes include: pioneering new scholarship; the enhancement of cross-institutional networks; and improved capacity for collaboration between academia and industry (professional bodies and collecting institutions). The project will benefit the nation, providing a truer understanding of the defining Australian sense of humour, press, and political culture, across more than 200 years.Read moreRead less
Brain Repair Following Stroke: The Role Of Npas4, A Neural-specific Transcription Factor
Funder
National Health and Medical Research Council
Funding Amount
$611,053.00
Summary
Stroke is the #1 cause of adult disability in Australia and #2 cause of death. About 60,000 Australians suffer a stroke each year while about 250,000 live with the disabilities of stroke, costing over $2B/year. The Queen Elizabeth Hospital and University of Adelaide will study why the Npas4 gene switches on after stroke and the role it plays in brain repair. Future health benefits may be tests to help improve stroke outcome in patients and therapy to decrease loss of brain cells after stroke.