Clinical And Psychosocial Changes Over Late Childhood And Adolescence And Early Life Determinants Of Long Term Clinical Outcomes In Cystic Fibrosis
Funder
National Health and Medical Research Council
Funding Amount
$1,135,570.00
Summary
Cystic fibrosis is the most common life shortening inherited disease in Caucasians. Lung damage starts in infancy and lung function falls most rapidly in adolescence although why and how this happens and early life determinants are not known. This study takes advantage of a previous study that monitored young children from 3 months to 5 years of life and follows them closely through early adolescence to investigate the protective and risk factors for falling lung function.
Burden Of Rheumatic Heart Disease (RHD) And Impact Of Prevention Strategies: Comprehensive Evidence To Drive The RHD Endgame
Funder
National Health and Medical Research Council
Funding Amount
$960,655.00
Summary
Rheumatic heart disease is chronic damage to the heart valves caused by repeated bouts of acute rheumatic fever. Both are preventable, yet rates among Indigenous Australians are of the highest recorded. We propose to undertake the first multi-jurisdictional study of these conditions to determine trends in occurrence and evaluate the impact of existing interventions in Australia. Findings will be used to inform the development of a roadmap to remove RHD as a public health problem in Australia.
Impact Of Health Policy On The Delivery Of Dental Services And Child Oral Health Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$1,304,799.00
Summary
This project will study the use of dental services by children and adolescents in Australia and how use relates to oral health outcomes. Variation in the support for the use of private dentists and the organisation and delivery of school dental services will be compared both within and across all states and territories so as to inform policy discussions on how to best improve child oral health.
Brain Repair Following Stroke: The Role Of Npas4, A Neural-specific Transcription Factor
Funder
National Health and Medical Research Council
Funding Amount
$611,053.00
Summary
Stroke is the #1 cause of adult disability in Australia and #2 cause of death. About 60,000 Australians suffer a stroke each year while about 250,000 live with the disabilities of stroke, costing over $2B/year. The Queen Elizabeth Hospital and University of Adelaide will study why the Npas4 gene switches on after stroke and the role it plays in brain repair. Future health benefits may be tests to help improve stroke outcome in patients and therapy to decrease loss of brain cells after stroke.
Responding to the threat of climate change: identifying effective strategies for the wheat industry of south-east Australia. This project will first evaluate the probable impacts of climatic change and variability on wheat production in southern Australia and will then assess the effectiveness of actual and potential adaptive management strategies designed to mitigate these impacts. The expected outcomes will include quantified impacts of future climate change and variability on wheat productio ....Responding to the threat of climate change: identifying effective strategies for the wheat industry of south-east Australia. This project will first evaluate the probable impacts of climatic change and variability on wheat production in southern Australia and will then assess the effectiveness of actual and potential adaptive management strategies designed to mitigate these impacts. The expected outcomes will include quantified impacts of future climate change and variability on wheat production in southern Australia, identification of regions at greater risk in the future and least likely to be viable in the longer run, and identification of effective adaptive management strategies designed to cope with these risks.Read moreRead less
ARC Australia-New Zealand Research Network for Vegetation Function. Plant species vary widely in quantitative functional traits, and in their relations to climate, soils and geography. Global generalizations are emerging. Vegetation Function network will reach from plant function into genomics and crop breeding, into palaeoecology and vegetation history, into landscape management for carbon, water and salinity outcomes, into forecasting future ecosystems under global change, and into phylogeny, ....ARC Australia-New Zealand Research Network for Vegetation Function. Plant species vary widely in quantitative functional traits, and in their relations to climate, soils and geography. Global generalizations are emerging. Vegetation Function network will reach from plant function into genomics and crop breeding, into palaeoecology and vegetation history, into landscape management for carbon, water and salinity outcomes, into forecasting future ecosystems under global change, and into phylogeny, ecoinformatics and evolutionary theory. Across this span, working groups will target nine identified opportunities for breakthrough research. Each research target needs input from two or more disciplines. Together, the nine targets link across disciplines, as a network that spans from genomic to planetary scales.Read moreRead less
Range dynamics and demographics of spatially structured populations under global change. Why are particular species present in some locations, but not others? This is a simple, fundamental ecological question, yet surprisingly, our answers on this point remain far from complete. Using an integrated, systems-based approach, we will determine the interplay between: (i) birth, death and movement rates, (ii) species interactions, and (iii) the constraints of the physical environment (temperature, ra ....Range dynamics and demographics of spatially structured populations under global change. Why are particular species present in some locations, but not others? This is a simple, fundamental ecological question, yet surprisingly, our answers on this point remain far from complete. Using an integrated, systems-based approach, we will determine the interplay between: (i) birth, death and movement rates, (ii) species interactions, and (iii) the constraints of the physical environment (temperature, rainfall, soil type), which determine the limits of species' ranges. Our models will provide Australian conservation managers with a novel, validated toolbox to explore the trade-offs, and synergies, inherent in trying to adapt to climate change and other stressors on biodiversity.Read moreRead less
Planning for a transformed future: Modelling synergistic climate change and land use impacts on biodiversity. Climate change poses a dire threat to Australia's biodiversity and natural resources due to its all-encompassing reach and the speed at which human-driven changes are taking place in already heavily modified systems. The proposed research, on modelling the synergistic impacts of anthropogenic threats, will provide new knowledge and innovative solutions for protecting unique ecosystems fa ....Planning for a transformed future: Modelling synergistic climate change and land use impacts on biodiversity. Climate change poses a dire threat to Australia's biodiversity and natural resources due to its all-encompassing reach and the speed at which human-driven changes are taking place in already heavily modified systems. The proposed research, on modelling the synergistic impacts of anthropogenic threats, will provide new knowledge and innovative solutions for protecting unique ecosystems facing severe environmental challenges this century. The validation of these new methods, which aim to capture ecological responses to global change, will represent a major and timely addition to the national research capability on climate change adaptation, and add to Australia's reputation as a global leader in the field of ecology.Read moreRead less
Occupational injury prevention in high temperature environments. This project aims to explore the contribution of heat as a risk factor in work-related illness and injury. Approximately 600 000 Australians experience a work-related illness or injury each year. Hot weather may directly or indirectly lead to accidents, but heat as a risk factor has not been systematically explored, and is particularly relevant in a warming climate. This project aims to improve safety and productivity in Australian ....Occupational injury prevention in high temperature environments. This project aims to explore the contribution of heat as a risk factor in work-related illness and injury. Approximately 600 000 Australians experience a work-related illness or injury each year. Hot weather may directly or indirectly lead to accidents, but heat as a risk factor has not been systematically explored, and is particularly relevant in a warming climate. This project aims to improve safety and productivity in Australian industry by generating new evidence and predictive models to inform injury prevention policy and guidance, and facilitating the development of practical, targeted resources. This project expects to add to the body of knowledge regarding workers’ health and safety and to be of benefit to industry and subpopulations at risk.Read moreRead less
Improving thermal environment of housing for older Australians. This project aims to develop strategies to improve the thermal environment of housing for older Australians based on systematic investigations of the links between weather, thermal comfort, energy use, and well-being. The project will produce evidence-based guidelines and a framework about planning/design issues and operational/behavioural aspects to support older people living independently. Improved thermal conditions will lead to ....Improving thermal environment of housing for older Australians. This project aims to develop strategies to improve the thermal environment of housing for older Australians based on systematic investigations of the links between weather, thermal comfort, energy use, and well-being. The project will produce evidence-based guidelines and a framework about planning/design issues and operational/behavioural aspects to support older people living independently. Improved thermal conditions will lead to better quality of life, reduce the need for institutional care and reduce public health costs. They will also provide environmental benefits through reduced energy use and carbon emissions.Read moreRead less