Population Health Planning For Rural Medicare Locals: Evaluating A Community Participation Method For Delivering Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$438,587.00
Summary
The study, in six communities, will evaluate whether an evidenced based method of rural community participation from the UK translates to assist healthcare planning by Medicare Locals. Medicare Locals must involve local people in designing services to improve health, but lack methods to do this. The focus of the study is oral health, a major issue in rural areas. The study evaluates whether new services are designed and implemented and whether there is change to health knowledge and behaviours.
Improving Sexual Health In Men With Prostate Cancer: Randomised Controlled Trial Of Exercise And Psychosexual Therapies
Funder
National Health and Medical Research Council
Funding Amount
$583,416.00
Summary
Sexual dysfunction is one of the most common and distressing side effects of prostate cancer. Despite being a critical survivorship care issue, there is a clear gap in knowledge surrounding the optimal treatment of sexual dysfunction in men with prostate cancer. This project examines whether exercise aids in the management of sexual dysfunction and explores if an integrated treatment model incorporating pharmacological, exercise and psychosexual therapies maximises improvement in sexual health.
New methodologies for representing and accessing resources on endangered languages: a case study from South Efate. Linguists produce material which has immense cultural significance as it is often the only record of endangered cultures. With new technologies come new ways of working with indigenous languages. This APD will develop an innovative methodology for documenting and archiving data from a language of the Pacific. It will do this by linking a dictionary, texts, audio, video, images and a ....New methodologies for representing and accessing resources on endangered languages: a case study from South Efate. Linguists produce material which has immense cultural significance as it is often the only record of endangered cultures. With new technologies come new ways of working with indigenous languages. This APD will develop an innovative methodology for documenting and archiving data from a language of the Pacific. It will do this by linking a dictionary, texts, audio, video, images and a grammar to facilitate presentation of both the data and its analysis to speakers, fellow linguists, and the general public. The methodology developed in this APD will result in innovative linguistic data management techniques conformant to emerging international standards.Read moreRead less
The Role Of Aspirin In The Prevention Of Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$1,725,799.00
Summary
ASPREE is a large, phase 3 clinical study of health participants over the age of 70 years who have been randomized to either continuous low dose aspirin or placebo for an average of 5 years. This grant is concerned with collecting long-term follow-up for an additional 5 years, especially for evidence of colorectal cancer (CRC) as well as the exploration of potential mechanisms of action by which aspirin may prevent the development of CRC.
KConFab - The Kathleen Cuningham Foundation Consortium For Research Into Familial Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$2,176,975.00
Summary
Breast cancer is the most common malignant disease of women. In families with an inherited form of breast cancer, nearly half the women in every generation can develop the disease. The aim of this Australasian-wide study is to complete collection of clinical, epidemiological and genetic data on 1,600 of these severely-affected families. The national resource is, and will continue to be, of great value for researchers who want to identify and characterize the genetic and life style factors that a ....Breast cancer is the most common malignant disease of women. In families with an inherited form of breast cancer, nearly half the women in every generation can develop the disease. The aim of this Australasian-wide study is to complete collection of clinical, epidemiological and genetic data on 1,600 of these severely-affected families. The national resource is, and will continue to be, of great value for researchers who want to identify and characterize the genetic and life style factors that affect onset and progression of the disease.Read moreRead less
Oral Tradition, Literacy and Education in Two Eastern Indonesian Societies. This project will improve our understanding of social and cultural change in eastern Indonesia, a region of strategic importance to Australia. The research will contribute significantly to knowledge of the educational system and literacy levels in eastern Indonesia. This knowledge will be of practical use in development projects in the region and to policy makers in Canberra who are concerned with Indonesian affairs. The ....Oral Tradition, Literacy and Education in Two Eastern Indonesian Societies. This project will improve our understanding of social and cultural change in eastern Indonesia, a region of strategic importance to Australia. The research will contribute significantly to knowledge of the educational system and literacy levels in eastern Indonesia. This knowledge will be of practical use in development projects in the region and to policy makers in Canberra who are concerned with Indonesian affairs. The involvement of a PhD student in the project will increase our national research capacity in eastern Indonesia. The contributions to anthropological theory and method this research will produce will enhance Australia's international reputation as a centre of anthropology, southeast Asian studies and the study of literacy.Read moreRead less
Expanding Diagnostic Approaches For Lynch Syndrome
Funder
National Health and Medical Research Council
Funding Amount
$1,269,355.00
Summary
Currently, there are ~1,000 families who have attended Family Cancer Clinics across Australia who have the hallmarks of having Lynch syndrome, a hereditary bowel cancer syndrome, but who have no gene defect identified, i.e. their cancer is unexplained. Clinicians are challenged by these “Lynch-like” patients as their family cancer risk is unknown. Our research has identified new gene defects in Lynch-like patients. Our aim is to optimise clinical testing approaches for Lynch-like patients.
Engineering MYCN Models Of High-grade Serous Ovarian Cancer (HGSC)
Funder
National Health and Medical Research Council
Funding Amount
$797,478.00
Summary
The most lethal type of ovarian cancer, high-grade serous cancer (HGSC), can be divided into four subtypes based on gene patterns. One subtype involves a set of genes/proteins that, in their specific combination, result in activation of a pathway known as MYCN. As most HGSC start in the fallopian tube, we are using fallopian tube material to make new MYCN HGSC models to observe development in the earliest stages. We hope to generate new tests and treatments for this subtype of ovarian cancer.
Exploiting And Defining The Immune Regulatory Activities Of BET Bromodomain Inhibitors
Funder
National Health and Medical Research Council
Funding Amount
$923,222.00
Summary
Immune-based agents such as “checkpoint inhibitors” have the ability to re-awaken our own immune systems and activate previously dormant anti-tumor responses. We have discovered that small molecule inhibitors of gene regulatory proteins called bromodomain proteins act synergistically with checkpoint inhibitors in mouse cancer models. We will define the molecular and biological events underpinning this novel combination approach and assess the effects of the combination across different tumors.
Tailoring Targeted Therapy To DNA Repair-defective High-Grade Serous Ovarian Cancer
Funder
National Health and Medical Research Council
Funding Amount
$802,247.00
Summary
Ovarian cancer is a major cause of cancer death in women because current treatments are inadequate. Half of aggressive ovarian cancers have abnormalities in DNA repair and should be susceptible to new PARP inhibitor therapy, yet not all those respond. By developing a new model of studying human ovarian cancers in mice, we can discover markers to predict which ovarian cancers will respond best to these exciting new treatments.