Genome-wide Association Studies Of Biomedical Traits And Endophenotypes For Complex Disease
Funder
National Health and Medical Research Council
Funding Amount
$295,804.00
Summary
The burden of common complex diseases, such as cardiovascular disease is substantial to the health care system. These diseases are caused by genes and environments as well as their interactions. The proposed project will identify genes affecting the susceptibility of individuals to complex diseases. Discovery of such genes will be important for their diagnosis, prevention and treatment and may serve as an important resource for future personalized medicine.
Optomechanical refrigeration of electronic circuits. The project aims to apply laser light to reduce the temperature of electronic circuits. This aims to greatly suppress electronic noise, and enable a new class of technologies for future telecommunication systems. By developing new techniques to confine light, electric fields and vibrations at sub-micron scale on a silicon chip, devices such as ultralow noise amplifiers, clocks and radio frequency receivers will be realised, along with ultra-ef ....Optomechanical refrigeration of electronic circuits. The project aims to apply laser light to reduce the temperature of electronic circuits. This aims to greatly suppress electronic noise, and enable a new class of technologies for future telecommunication systems. By developing new techniques to confine light, electric fields and vibrations at sub-micron scale on a silicon chip, devices such as ultralow noise amplifiers, clocks and radio frequency receivers will be realised, along with ultra-efficient optical modulators. In future, these technologies could reduce energy consumption and improve reliability in telecommunication networks. They could improve the range of satellite communication, robustness of GPS against cosmic radiation, and performance of surveillance systems such as radar and sonar.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120101721
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Probing the excited states of organic semiconductor systems with photoinduced absorption spectroscopy. Plastic semiconductors have the potential to revolutionise consumer electronics by enabling cheap, flexible and low power devices. The success of these devices depends on our understanding of the optical and electronic properties of the materials, which this project aims to address through the use of photoinduced absorption spectroscopy.
Next generation lasers for short-reach optical fibre communication. This project aims to develop next-generation laser systems for multimode fibre-optic communication systems, by leveraging recently developed techniques for measuring and controlling the spatial properties of light. These techniques will provide new insights into the physics of the lasers themselves, as well as overcoming fundamental limitations which have traditionally hindered their operation at high speed. The expected outcome ....Next generation lasers for short-reach optical fibre communication. This project aims to develop next-generation laser systems for multimode fibre-optic communication systems, by leveraging recently developed techniques for measuring and controlling the spatial properties of light. These techniques will provide new insights into the physics of the lasers themselves, as well as overcoming fundamental limitations which have traditionally hindered their operation at high speed. The expected outcome of this project is the inclusion of these techniques in the development and operation of future generations of fibre communication systems. Creating new classes of laser systems, which can scale to large bit rates, will enable the growth in this area to be sustained into the future.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100009
Funder
Australian Research Council
Funding Amount
$455,000.00
Summary
Ultra-precision cutting and polishing machines for fabricating high-Q crystalline resonators. The proposed facility will equip Australian researchers with the capability to machine and polish optical crystalline materials down to atomic-level smoothness. The availability of this technology will enable the fabrication of ultra-sensitive metrological sensors, state-of-the-art photonic components, and quantum devices. Precision metrology is an integral component of many industries and it underpins ....Ultra-precision cutting and polishing machines for fabricating high-Q crystalline resonators. The proposed facility will equip Australian researchers with the capability to machine and polish optical crystalline materials down to atomic-level smoothness. The availability of this technology will enable the fabrication of ultra-sensitive metrological sensors, state-of-the-art photonic components, and quantum devices. Precision metrology is an integral component of many industries and it underpins a modern, technically advanced society. With this facility Australian researchers will lead the world in the fabrication of optical crystalline devices for a broad range of industrial and research applications.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100934
Funder
Australian Research Council
Funding Amount
$439,082.00
Summary
Taming the light: full control in polarisation, space, and time. This project aims to develop two prototype optical beam shaping systems, culminating in the demonstration of new high-power optical fibre amplifiers. This novel ability to control all the properties of light enables the generation of optical beams that were only theoretical ideas but never previously implemented experimentally. This advanced technology can potentially open new ways in which objects can be probed using light. Expect ....Taming the light: full control in polarisation, space, and time. This project aims to develop two prototype optical beam shaping systems, culminating in the demonstration of new high-power optical fibre amplifiers. This novel ability to control all the properties of light enables the generation of optical beams that were only theoretical ideas but never previously implemented experimentally. This advanced technology can potentially open new ways in which objects can be probed using light. Expected outcomes include the creation of an optical platform that the optical community at large may utilise for their specific applications. Besides the intellectual property benefits of such optical devices directly, this project should bridge the gap between the developed knowledge and commercial opportunities.Read moreRead less
Control of light in space and time in multimode optical fibres. This project aims to create devices to measure and manipulate the spatial and temporal properties of light. The ability to control or measure the spatial and/or temporal properties of light is a fundamental feature of many applications, including biomedical imaging, astronomy, telecommunications, high-power lasers and quantum computing. This project will develop five prototype systems to control the spatiotemporal properties of ligh ....Control of light in space and time in multimode optical fibres. This project aims to create devices to measure and manipulate the spatial and temporal properties of light. The ability to control or measure the spatial and/or temporal properties of light is a fundamental feature of many applications, including biomedical imaging, astronomy, telecommunications, high-power lasers and quantum computing. This project will develop five prototype systems to control the spatiotemporal properties of light in ways that were previously not possible. This would affect fundamental and applied applications where the inability to sufficiently control light’s spatial and/or temporal properties is an impediment. Examples include imaging deep into ‘opaque’ objects such as human skin or brain, high-power lasers for material processing and manufacturing, optical telecommunications and quantum computation.Read moreRead less
Estimation of non-additive genetic variance for complex traits using genome-wide single nucleotide polymorphyisms and sequence data. Finding genes for traits of importance in agriculture, ecology and human health depends on understanding the genetic basis of these traits. This project will investigate whether variation in traits in humans, cattle and wild sheep are influenced by gene-gene interactions.
The genetic architecture and evolution of quantitative traits. Most important traits are controlled by many genes and by the environment, however there is little knowledge of how many genes are involved in these complex traits and what their effects are. This project will describe the number of genes and their effects for complex traits in humans and livestock and explain how these genes evolve.
This study investigates how much an individual's genes and environment account for the wide variation in brain structure and function. Using brain imaging we examine in what way the connectivity of the brain of identical and non-identical twins is the same or different from that of their co-twin, and carry out analysis of their DNA to identify some of the genes involved. This will provide fundamental information on genetic mechanisms influencing variation in brain structure and function.