Characterization Of Cellular Inflammatory Responses Underlying Acute Viral Bronchiolitis In Infants
Funder
National Health and Medical Research Council
Funding Amount
$583,224.00
Summary
This project seeks to characterize the inflammatory mechanisms triggered during severe respiratory virus infections that result in hospitalization of infants. These are associated with later development of asthma. We aim to identify new molecular targets for anti-inflammatory drug development, with the long term goals of improving treatment for acute disease, and prevention of subsequent asthma.
Can Pentoxifylline Improve Long-term Outcomes In Preterm Infants With Late-onset Sepsis Or Necrotizing Enterocolitis – A Pragmatic, Randomized, Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$2,901,130.00
Summary
Very preterm infants are at high risk of death and disability. Brain injury is often the result of inflammation caused by infection or bowel disease. To date, there is no treatment to reduce the harmful effects of inflammation. Pentoxifylline reduces inflammation and is a promising, safe and inexpensive treatment option for preterm infants. This study will determine whether Pentoxifylline in addition to antibiotics improves survival without disability in preterm infants.
Contribution Of Systemic Inflammatory Response To Brain Injury In Growth Restricted Newborns
Funder
National Health and Medical Research Council
Funding Amount
$363,388.00
Summary
Growth restriction during pregnancy can damage the baby’s brain and result in poor outcomes such as learning and attention difficulties and cerebral palsy. Currently there is no treatment available to prevent brain injury in these babies. This study will explore the role of inflammation and brain injury in the growth restricted baby. We will also examine whether a readily available and safe anti-inflammatory treatment can reduce or prevent brain injury following growth restriction.
Early Environmental Determinants Of Pancreatic Islet Autoimmunity: A Pregnancy To Early Life Cohort Study In Children At Risk Of Type 1 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$1,124,069.00
Summary
The doubling in incidence of type 1 diabetes in children over the last 20 years may be explained by our modern environment, including excessive weight gain in pregnancy and early life, inadequate dietary omega- 3 fatty acids or vitamin D, or viral infections. We therefore aim to study children with a family member with type 1 diabetes from the pregnancy and through early childhood to determine the effects of the environment on their risk of developing type 1 diabetes .This will lead to strategie ....The doubling in incidence of type 1 diabetes in children over the last 20 years may be explained by our modern environment, including excessive weight gain in pregnancy and early life, inadequate dietary omega- 3 fatty acids or vitamin D, or viral infections. We therefore aim to study children with a family member with type 1 diabetes from the pregnancy and through early childhood to determine the effects of the environment on their risk of developing type 1 diabetes .This will lead to strategies to prevent type 1 diabetes.Read moreRead less
Epithelial Drivers Of Neutrophil Plasticity In Early Cystic Fibrosis Lung Disease
Funder
National Health and Medical Research Council
Funding Amount
$849,462.00
Summary
Why airway inflammation becomes chronic so early in life for people with cystic fibrosis (CF) is unclear. This project will use the latest techniques to characterise immune cells found in airways of infants with CF and model in the laboratory how immune cells react to the CF airway. We will challenge CF airway cells with different bugs that can infect the lung, then see if the responses by CF airway cells can change the normal response of immune cells, triggering chronic disease.