ELEMENTS: A Virtual-Reality Augmented Workspace for Movement Rehabilitation of Traumatic Brain Injury Patients. The broad aim of the project is to design, develop and evaluate an interactive virtual environment (VE) called ELEMENTS that supports movement assessment and rehabilitation for patients recovering from Traumatic Brain Injury (TBI). We will use current knowledge of the neural basis of movement control and learning to create VEs that will help re-train patients' sense of multimodal space ....ELEMENTS: A Virtual-Reality Augmented Workspace for Movement Rehabilitation of Traumatic Brain Injury Patients. The broad aim of the project is to design, develop and evaluate an interactive virtual environment (VE) called ELEMENTS that supports movement assessment and rehabilitation for patients recovering from Traumatic Brain Injury (TBI). We will use current knowledge of the neural basis of movement control and learning to create VEs that will help re-train patients' sense of multimodal space, their position within it, and the predictive control of actions. We will adapt our training environments for use on readily available technologies, creating a treatment method amenable to remote delivery. This will extend rehabilitation practices beyond their current constraints.Read moreRead less
Participation following traumatic brain injury in rural, regional and remote areas. The results of this project will lead to improved rehabilitation programs and better outcomes for people with brain injury, especially in regional, rural and remote areas, by targeting the ultimate goal more directly: participation - getting people back into their home, work and community roles. Participation is associated with improved social networks, wellbeing, independence and quality of life, so health care ....Participation following traumatic brain injury in rural, regional and remote areas. The results of this project will lead to improved rehabilitation programs and better outcomes for people with brain injury, especially in regional, rural and remote areas, by targeting the ultimate goal more directly: participation - getting people back into their home, work and community roles. Participation is associated with improved social networks, wellbeing, independence and quality of life, so health care burdens and costs are reduced, and people can lead more productive lives. The project's emphasis on country areas will benefit rural health care, and also help specialist metropolitan brain injury services to understand the specific rehabilitation issues facing people from the bush.Read moreRead less
Improved identification of patients 'at risk' of depression, and optimal targeting of rehabilitation post-stroke through novel brain imaging and biomarkers. Use of novel brain imaging and biomarkers for identification of stroke survivors at risk of depression and recurrent stroke will permit early access to preventative and effective treatments for depression and improve capacity to benefit from rehabilitation. Development of predictive models to guide selection of most optimal rehabilitation st ....Improved identification of patients 'at risk' of depression, and optimal targeting of rehabilitation post-stroke through novel brain imaging and biomarkers. Use of novel brain imaging and biomarkers for identification of stroke survivors at risk of depression and recurrent stroke will permit early access to preventative and effective treatments for depression and improve capacity to benefit from rehabilitation. Development of predictive models to guide selection of most optimal rehabilitation strategies based on viable brain will maximise the capacity for persons with stroke to reach their full potential for recovery and ensure rehabilitation is more targeted and cost efficient. Improved capacity to benefit from treatment will have ongoing benefits for activity participation and productive living in Australians who experience stroke.Read moreRead less
A hands-free assistive control system for the severely disabled capable of operating under stressful and fatiguing conditions. The impact of severe disability like tetraplegia in daily living is substantial. Strategies are needed to improve their quality of life. One approach is to enhance their independence by providing 'hands free' control over their environment. However, few scientific studies have examined the efficacy of such technology. The aim of this research is to study the brain activi ....A hands-free assistive control system for the severely disabled capable of operating under stressful and fatiguing conditions. The impact of severe disability like tetraplegia in daily living is substantial. Strategies are needed to improve their quality of life. One approach is to enhance their independence by providing 'hands free' control over their environment. However, few scientific studies have examined the efficacy of such technology. The aim of this research is to study the brain activity of users of our "hands free" technology when they are operating under stressful and fatiguing conditions. The study should provide valuable data that will allow us to improve the efficacy of our existing brain signal based system (Mind Switch Assistive System). Read moreRead less
Improving Outcome after Stroke through Earlier Rehabilitation: The Very Early Rehabilitation Research Program. Stroke presents a major, growing global public health challenge accounting for 25% of all chronic disability. Treatments that reduce the burden of stroke are urgently needed, and early rehabilitation may significantly reduce chronic disability. A large, high quality, National Health and Medical Research Council funded clinical trial is at the heart of the A Very Early Rehabilitation Tri ....Improving Outcome after Stroke through Earlier Rehabilitation: The Very Early Rehabilitation Research Program. Stroke presents a major, growing global public health challenge accounting for 25% of all chronic disability. Treatments that reduce the burden of stroke are urgently needed, and early rehabilitation may significantly reduce chronic disability. A large, high quality, National Health and Medical Research Council funded clinical trial is at the heart of the A Very Early Rehabilitation Trial (AVERT) program. The trial tests whether a simple, rehabilitation intervention (early and intensive out of bed activity) results in fewer deaths and less disability for stroke sufferers and is cost effective. If effective the intervention could be adopted across different health services both here and overseas, reducing the global burden of stroke.Read moreRead less
Interlimb coordination dynamics in stroke. Everyday we use our limbs in a coordinated manner. However, for a person who has suffered a stroke resulting in weakness on one side of the body even the simplest interlimb coordination tasks are difficult to perform. This project will examine interlimb coordination in persons who have suffered a stroke and explore whether the coupling between limbs can be exploited to promote fuctional recovery of an impaired limb. In particular, the research seeks to ....Interlimb coordination dynamics in stroke. Everyday we use our limbs in a coordinated manner. However, for a person who has suffered a stroke resulting in weakness on one side of the body even the simplest interlimb coordination tasks are difficult to perform. This project will examine interlimb coordination in persons who have suffered a stroke and explore whether the coupling between limbs can be exploited to promote fuctional recovery of an impaired limb. In particular, the research seeks to identify the critical components underlying the effectiveness of an intervention involving the pratice of actions bilaterally and simultaneously.Read moreRead less
Effective management of challenging behaviours in cognitively impaired aged care residents through a research-based nursing care model. Challenging behaviours associated with cognitive impairment, such as screaming and perseveration, marks a decisive turning point in the life situation for an older person, heralding a deterioration in their quality of life and placement in an aged care facility. Staff can promote the residents health and well-being through person-centred care approaches. The stu ....Effective management of challenging behaviours in cognitively impaired aged care residents through a research-based nursing care model. Challenging behaviours associated with cognitive impairment, such as screaming and perseveration, marks a decisive turning point in the life situation for an older person, heralding a deterioration in their quality of life and placement in an aged care facility. Staff can promote the residents health and well-being through person-centred care approaches. The study employs Dementia Care Mapping to achieve these goals for the resident through participatory action research. The expected outcomes are a significant reduction in contextual factors that trigger these challenging behaviours, an improvement in the residents health, well-being and quality of life, and increased knowledge, skills and empowerment in staff.Read moreRead less
Epigenetic mechanisms regulating sex differences in fear-related learning and memory. Anxiety disorders represent an enormous burden on society and are associated with premature aging and infertility in men and women. Evidence also indicates that parental anxiety affects child development. Given that fear-related learning has an important influence on emotional health which, in turn, affects lifestyle and the aging process, an understanding of the neural mechanisms mediating sex differences in ....Epigenetic mechanisms regulating sex differences in fear-related learning and memory. Anxiety disorders represent an enormous burden on society and are associated with premature aging and infertility in men and women. Evidence also indicates that parental anxiety affects child development. Given that fear-related learning has an important influence on emotional health which, in turn, affects lifestyle and the aging process, an understanding of the neural mechanisms mediating sex differences in fear learning will enhance our ability to develop better therapeutic approaches for treating anxiety and preventing relapse, potentially through a gender-specific approach. The studies outlined in this proposal will have implications for promoting and maintaining good health.Read moreRead less
Assessing gene function in the developing brain using zebrafish as a model system. As the average life expectancy in western countries increases there is an increasing incidence of mental health problems in the general population. Therapeutic approaches to Alzhemier's and Parkinson's disease as well as to brain injury arising from stroke rely on a thorough understanding of the molecular and physiological mechanisms of normal growth of this tissue. These are the very processes that need to be rea ....Assessing gene function in the developing brain using zebrafish as a model system. As the average life expectancy in western countries increases there is an increasing incidence of mental health problems in the general population. Therapeutic approaches to Alzhemier's and Parkinson's disease as well as to brain injury arising from stroke rely on a thorough understanding of the molecular and physiological mechanisms of normal growth of this tissue. These are the very processes that need to be reactivated in these diseases for recovery of function. This project seeks to understand normal development of the brain and in doing so it will expose novel targets for therapy in the aged. Read moreRead less
The burden of epilepsy study: Impact on well-being, service use and economic outcomes. This research into the humanitarian needs of people with epilepsy is a necessary extension to the current bulk of knowledge about epilepsy which is diagnostic, clinical and pharmacological. Its focus is on well-being, service use and economic burden this study is expected to give a good return on investment. To ensure an uptake of its findings, the study was developed with the national Epilepsy Action, Epilep ....The burden of epilepsy study: Impact on well-being, service use and economic outcomes. This research into the humanitarian needs of people with epilepsy is a necessary extension to the current bulk of knowledge about epilepsy which is diagnostic, clinical and pharmacological. Its focus is on well-being, service use and economic burden this study is expected to give a good return on investment. To ensure an uptake of its findings, the study was developed with the national Epilepsy Action, Epilepsy Society of Australia as well as addressing questions deemed important by the World Health Organization, the International League against Epilepsy, and the International Bureau of Epilepsy. Findings will inform epilepsy guidelines, policy recommendations and programs to reduce the burden of illness.Read moreRead less