Target Of Rapamycin control of nutrient uptake. This project aims to study nutrient uptake in eukaryotes. It is expected to generate new knowledge of critical and conserved features of environmental and Target Of Rapamycin (TOR)-mediated control of nutrient uptake, specifically endocytosis, building on novel preliminary data that identifies novel TOR control points. The expected outcomes include new insights into mechanisms controlling nutrient uptake and fostering institutional collaboration. T ....Target Of Rapamycin control of nutrient uptake. This project aims to study nutrient uptake in eukaryotes. It is expected to generate new knowledge of critical and conserved features of environmental and Target Of Rapamycin (TOR)-mediated control of nutrient uptake, specifically endocytosis, building on novel preliminary data that identifies novel TOR control points. The expected outcomes include new insights into mechanisms controlling nutrient uptake and fostering institutional collaboration. This knowledge is highly relevant to any industry or research project utilising living organisms, as nutrient availability supports survival, cell growth and proliferation.Read moreRead less
How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent si ....How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent signaling. Expected outcomes include novel insights into environmental control of cell proliferation and forging cross institutional collaborations. This knowledge benefits basic and applied biology and is relevant to industries/projects utilizing living cells as nutrient supports cell survival and proliferation.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100628
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
Promotion of NAD+ anabolism to promote lifespan. The project aims to identify mechanisms of ageing, the role of stress on the ageing brain and how NAD+ modulates these effects. NAD+ maintains cellular energy, repairs DNA and performs other essential cell functions. Intracellular NAD+ levels, the essential substrate for sirtuin activity including SIRT2, decline with age in humans and physiologically aged rats. This project will investigate the mechanisms by which pharmacological strategies design ....Promotion of NAD+ anabolism to promote lifespan. The project aims to identify mechanisms of ageing, the role of stress on the ageing brain and how NAD+ modulates these effects. NAD+ maintains cellular energy, repairs DNA and performs other essential cell functions. Intracellular NAD+ levels, the essential substrate for sirtuin activity including SIRT2, decline with age in humans and physiologically aged rats. This project will investigate the mechanisms by which pharmacological strategies designed to elevate intracellular NAD+ levels will maintain optimal SIRT2 function to extend lifespan and improve age-related cognitive decline in vivo. Potential outcomes include using NAD+ to improve brain health in advanced old age.Read moreRead less
Impacts of diet on the brain, body, and microbiome. Dietary habits determine cognitive function, metabolism and the composition of the gut microbiome. This project seeks to clarify the role of the gut microbiome in diet-induced changes to cognition. It aims to do so through longitudinal studies of cognitive function in which dietary patterns are systematically varied, and intervention studies where cognition is tested after experimentally manipulating the gut microbiome. Expected outcomes inclu ....Impacts of diet on the brain, body, and microbiome. Dietary habits determine cognitive function, metabolism and the composition of the gut microbiome. This project seeks to clarify the role of the gut microbiome in diet-induced changes to cognition. It aims to do so through longitudinal studies of cognitive function in which dietary patterns are systematically varied, and intervention studies where cognition is tested after experimentally manipulating the gut microbiome. Expected outcomes include new interdisciplinary knowledge spanning psychology, neuroscience, nutrition and metabolism. This project is timely given the enormous shifts in Australian dietary choices. The knowledge to be gained should provide benefits to individual and public health, agriculture, and food systems.Read moreRead less
Breeding super black soldier flies at scale for sustainable food production. This project aims to address the current challenges impeding the industrial scale-up of Australian Black Soldier Fly (BSF) farming across diverse feed waste substrates by generating critical on-farm knowledge. This project expects to generate fundamental knowledge in commercial BSF breeding designs whilst also developing and testing new animal evaluation technologies (ie, genetic & spectroscopy) through interdisciplinar ....Breeding super black soldier flies at scale for sustainable food production. This project aims to address the current challenges impeding the industrial scale-up of Australian Black Soldier Fly (BSF) farming across diverse feed waste substrates by generating critical on-farm knowledge. This project expects to generate fundamental knowledge in commercial BSF breeding designs whilst also developing and testing new animal evaluation technologies (ie, genetic & spectroscopy) through interdisciplinary approaches that will accelerate industry productivity. Expected outcomes of this project include the long-term growth and competitive advantage of the Australian insect farming industry, as well as promoting the benefits of a circular economy through bioconversion of organic waste into commercially viable products.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100908
Funder
Australian Research Council
Funding Amount
$461,815.00
Summary
Maximising the beneficial impacts of mycorrhizal fungi on grain nutrition. This project aims to determine the effects of beneficial soil fungi on wheat and rice grain quality for human nutrition using an innovative combination of physiological, molecular and agronomic techniques. The project expects to generate fundamental knowledge in sustainable agriculture, to improve grain quality and value. Expected outcomes of this project include enhanced understanding of the mechanisms underlying improve ....Maximising the beneficial impacts of mycorrhizal fungi on grain nutrition. This project aims to determine the effects of beneficial soil fungi on wheat and rice grain quality for human nutrition using an innovative combination of physiological, molecular and agronomic techniques. The project expects to generate fundamental knowledge in sustainable agriculture, to improve grain quality and value. Expected outcomes of this project include enhanced understanding of the mechanisms underlying improved grain quality, and the capacity to use soil fungi to increase grain micronutrient concentrations and bioavailability. This should provide significant environmental and societal benefits, such as promotion of the sustainable use of agricultural soils and more nutritious grain products for human consumption.Read moreRead less
Development of drought tolerant, high protein legume for arid Australia. The aim of this research is to demonstrate the molecular basis of a non-proteinogenic amino acid toxin accumulation by using genomics and genome editing to produce a non-transgenic, protein rich legume. The significance of the outcomes will be a fundamental understanding of how non-proteinogenic amino acids are metabolised in plants and an inexpensive, high-protein feed for the pork and chicken industries thereby reducing p ....Development of drought tolerant, high protein legume for arid Australia. The aim of this research is to demonstrate the molecular basis of a non-proteinogenic amino acid toxin accumulation by using genomics and genome editing to produce a non-transgenic, protein rich legume. The significance of the outcomes will be a fundamental understanding of how non-proteinogenic amino acids are metabolised in plants and an inexpensive, high-protein feed for the pork and chicken industries thereby reducing production costs and increasing profitability. The outcomes from the research are fundamental knowledge of non-proteinogenic amino acid metabolism and turnkey approach to identify, engineer, test and produce value added crops. The benefits of the research are a multi-purpose crop for Australian crop and animal producers.Read moreRead less