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Improving The Health And Development Of High Risk Preterm Newborns
Funder
National Health and Medical Research Council
Funding Amount
$338,381.00
Summary
Preterm children have more health and developmental problems than those born full term. Although we know the problems faced by those tiniest and most immature, more questions remain. What problems do they face as adults? What new treatments are available to improve their outcomes? Are the more “mature” preterms at risk as well? My research program aims to address these questions through the efforts of the Victorian Infant Collaborative Study team, a large research team that I lead.
The mortality rate from community-acquired pneumonia has not improved over the past four decades. New pulmonary infectious diseases such as due to non tuberculous mycobacteria are causing increasing problems and bronchiectasis is responsible for an ever increasing mortality, morbidity and economic burden on our health system. This grant will support Professor Waterer in continuing to reduce the personal and society burden of pulmonary infections.
Macrophage inhibitory cytokine-1 (MIC-1) participates in cancer, stroke and heart attack. Studies show that measurement of MIC-1 in blood and cancer tissue might be useful to detect the development of cancer and determine whether it will spread. Also, MIC-1 measurement can identify people who are at risk of dying of cancer, heart attack and stroke. This study will show how MIC-1 may be used to prevent, diagnose and help treat these conditions and reduce healthcare costs.
Multiple sclerosis is the most common cause of neurological disability among young adults. The patients’ individual response to therapy is highly variable. The research vision completed during this Fellowship will generate novel evidence enabling individually-tailored therapy of multiple sclerosis. Through the newly established Clinical Outomes Research Unit at the Royal Melbourne Hospital, the expertise from observational data in multiple sclerosis will be applied in other areas of neurology.
Understanding And Effectively Treating Cognitive And Functioning Impairments In Youth With Psychosis And Other Mental Disorders
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Impaired thinking skills, such as memory, concentration and problem solving, emerge early in psychotic and other mental disorders, which has a negative impact on functioning in work and other daily activities. Current treatments are not very effective at addressing this. The research proposed in this fellowship will improve knowledge about these impairments and develop and test a range of interventions that treat thinking skill difficulties and improve daily functioning in youth mental illness.
Identifying Patient-centred Outcomes For People With Chronic Kidney Disease And Translating Them Into Policy And Practice
Funder
National Health and Medical Research Council
Funding Amount
$463,652.00
Summary
This 4 year fellowship project engages with patients, caregivers, clinicians, researchers and policy makers, to establish core outcomes and outcome measures in dialysis and transplantation. This will ensure that patient-centred outcomes are consistently measured and reported in dialysis and transplantation trials and other forms of research.
Optimising Patient Outcomes Following Surgery: Bridging The Fields Of Antimicrobial Stewardship, Microbiology And Infection Prevention
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Over 2.4 million surgeries are performed yearly in Australia. Up to 15% of procedures are complicated by infection leading to patient suffering. These infections are also implicated in the emergence of antibiotic resistance. My research will help us understand how infections develop, how to prevent these infections and how to incorporate best-practice into patient care. My research will bridge these key areas to help improve outcomes for patients undergoing surgical procedures.