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Mathematics in the round - the challenge of computational analysis on spheres. Real world problems formulated on spheres (including physical problems for the whole earth) provide many difficult challenges. This project aims at developing algorithms to solve problems on spheres in two and higher dimensions, with applications ranging from geophysics to signal analysis.
Discovery Early Career Researcher Award - Grant ID: DE160100227
Funder
Australian Research Council
Funding Amount
$355,481.00
Summary
Experimentally validated multiphase mathematical models of leg ulcers. The project is designed to develop mathematical models of the complex biological processes of leg ulcer formation and healing. The project intends to combine mathematical techniques from fluid dynamics, mathematical biology, numerical analysis and statistical inference to develop novel, multiphase, validated mathematical models that capture the complex spatiotemporal evolution of cellular and chemical species during the forma ....Experimentally validated multiphase mathematical models of leg ulcers. The project is designed to develop mathematical models of the complex biological processes of leg ulcer formation and healing. The project intends to combine mathematical techniques from fluid dynamics, mathematical biology, numerical analysis and statistical inference to develop novel, multiphase, validated mathematical models that capture the complex spatiotemporal evolution of cellular and chemical species during the formation and healing of a leg ulcer – biological processes which are currently poorly understood. The mathematical models are expected to provide new insight into the underlying biological mechanisms of leg ulcers and may ultimately improve management of chronic wounds.Read moreRead less
Can an anti-HIV gene in blood stem cells protect from immune depletion by HIV? Approximately 15,000 individuals in Australia are currently HIV infected. Gene therapy has the capacity to remove antiretroviral treatment related issues, dramatically decrease treatment costs and simplify treatment of HIV.
In this study we will model a new approach to treat HIV in which the patient's own cells are used as the therapy by incorporating an anti-HIV gene. These cells are then re-introduced into the p ....Can an anti-HIV gene in blood stem cells protect from immune depletion by HIV? Approximately 15,000 individuals in Australia are currently HIV infected. Gene therapy has the capacity to remove antiretroviral treatment related issues, dramatically decrease treatment costs and simplify treatment of HIV.
In this study we will model a new approach to treat HIV in which the patient's own cells are used as the therapy by incorporating an anti-HIV gene. These cells are then re-introduced into the patient.
The strong mathematical focus of this project, and its application to a promising approach against HIV, will place Australia at the forefront of the mathematics of gene research and contribute to the National Priority Area of Promoting and Maintaining Good Health and the Priority Goal of Preventative Healthcare.
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Filled function methods for global optimization and their applications. Many real problems in science, commerce and industry are restricted in the way that they are modelled and solved by the known inability to deal with global optimization problems. The development of computational efficient global optimization methods in this project will allow new more complete approaches to these problems, especially in new areas of bio-informatics, data mining, economic modelling, supply chain management, ....Filled function methods for global optimization and their applications. Many real problems in science, commerce and industry are restricted in the way that they are modelled and solved by the known inability to deal with global optimization problems. The development of computational efficient global optimization methods in this project will allow new more complete approaches to these problems, especially in new areas of bio-informatics, data mining, economic modelling, supply chain management, air traffic management, biochemical engineering and automotive industry, consequently helping Australia advance in these various areas. It will also enhance the understanding of global optimization from both theoretical and numerical viewpoints, particularly boosting optimization research in Australia.Read moreRead less
Very high dimensional computation - the new frontier in numerical analysis. High-dimensional problems, involving hundreds or thousands of variables, arise in applications from finance, health statistics and oil reservoir modelling to physics and chemistry. This project aims to develop the science of high-dimensional computation, as driven by important applications such as the flow of groundwater through a porous material.
Geometric Methods in Geophysical Fluid Dynamics. The need for a reliable weather forecast has never been more evident. This project addresses fundamental problems which are obstacles to more accurate weather forecasts. The dynamics of the atmosphere and the oceans is inherently complex. The complexity of the flow is confined though by conservation laws. This observation has not yet been used in current weather models. These conservation laws will be the guiding principle for the design of a stab ....Geometric Methods in Geophysical Fluid Dynamics. The need for a reliable weather forecast has never been more evident. This project addresses fundamental problems which are obstacles to more accurate weather forecasts. The dynamics of the atmosphere and the oceans is inherently complex. The complexity of the flow is confined though by conservation laws. This observation has not yet been used in current weather models. These conservation laws will be the guiding principle for the design of a stable numerical integration scheme.
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Solving inverse problems with Iterative regularisation and convex penalties. This project aims to develop and investigate new computational procedures for the solution of inverse problems which do not have the usual smoothness properties (or source conditions) required for the traditional regularisation methods. Examples of such inverse problems are very common and include image restoration, photo-acoustic tomography and spectroscopy. It is anticipated that this project will substantially extend ....Solving inverse problems with Iterative regularisation and convex penalties. This project aims to develop and investigate new computational procedures for the solution of inverse problems which do not have the usual smoothness properties (or source conditions) required for the traditional regularisation methods. Examples of such inverse problems are very common and include image restoration, photo-acoustic tomography and spectroscopy. It is anticipated that this project will substantially extend the toolbox of methods for such problems utilising ideas from Banach spaces, convex analysis, parallel computing and optimisation. This project is expected to make a substantial contribution to a better understanding of inverse problems and their solution procedures.Read moreRead less
Unified approach for the stability analysis of large concrete dams due to ageing degradation. The expected outcome of this research is the availability of an innovative methodology for the safety assessment of aged concrete dams. Most of the concrete dams built in Australia and elsewhere have been in service for over 50 years. Degradation effects on aged concrete dams, and resistant ability of such aged concrete dams against hostile natural events, such as earthquakes, are of great concern for e ....Unified approach for the stability analysis of large concrete dams due to ageing degradation. The expected outcome of this research is the availability of an innovative methodology for the safety assessment of aged concrete dams. Most of the concrete dams built in Australia and elsewhere have been in service for over 50 years. Degradation effects on aged concrete dams, and resistant ability of such aged concrete dams against hostile natural events, such as earthquakes, are of great concern for engineers. The safety assessment of aged concrete dams can be done rationally by the proposed method which will provide a better knowledge of the ageing effects on concrete dams. The approach will provide a tool for rational decision-making as to the structural rehabilitation of large concrete dams affected by ageing degradation.Read moreRead less
A Computational Study of Nonconvex and Nonlinear Semi-infinite Optimisation Problems in Signal Processing. The operation of filtering is an important part of most modern communication engineering systems. Many important problems, which arise naturally from communications engineering applications, can be formulated as nonconvex optimization problems and nonlinear semi-infinite and/or semi-definite optimization problems. New optimization theory, in combination with novel computationally efficient ....A Computational Study of Nonconvex and Nonlinear Semi-infinite Optimisation Problems in Signal Processing. The operation of filtering is an important part of most modern communication engineering systems. Many important problems, which arise naturally from communications engineering applications, can be formulated as nonconvex optimization problems and nonlinear semi-infinite and/or semi-definite optimization problems. New optimization theory, in combination with novel computationally efficient solution methods, and efficient hardware implementation will be developed. The outcomes will enhance Australia's reputation in this cutting edge research and facilitate opportunity for international collaboration as well as commercial opportunity. The project will also provide an excellent environment for the training of junior researchers in the area.Read moreRead less
HYBRID METHODS FOR SOLVING LARGE-SCALE OPTIMISATION PROBLEMS. Mathematical modelling and optimisation plays a crucial role in the advancement of modern business, science and technology. A significant benefit of this project is the development of a range of powerful computational tools for improving the productivity of Australian industry, including: agriculture; communications; defence; manufacturing; mining and petroleum; transport and logistics. These tools will be built upon advances in the f ....HYBRID METHODS FOR SOLVING LARGE-SCALE OPTIMISATION PROBLEMS. Mathematical modelling and optimisation plays a crucial role in the advancement of modern business, science and technology. A significant benefit of this project is the development of a range of powerful computational tools for improving the productivity of Australian industry, including: agriculture; communications; defence; manufacturing; mining and petroleum; transport and logistics. These tools will be built upon advances in the fundamental theory developed by the research team. The resulting high quality publications and associated algorithms will greatly enhance Australia's international scientific reputation and provide Australian industry with new cutting-edge optimisation technology.Read moreRead less