Role Of SPPL2A On B Cell Survival And Antibody Production In Mice And Humans
Funder
National Health and Medical Research Council
Funding Amount
$592,989.00
Summary
B lymphocytes are a specialised type of blood cells that produce antibodies in response to a pathogen or a vaccine. We have recently discovered that all mature B cells depend for their survival on a previously unknown protein called SPPL2A. This application will investigate the molecular mechanism through which SPPL2A contributes to the survival of B cells. We will also investigate if humans with currently unexplained B cell deficiency have mutations in SPPL2A.
Pure and applied nuclear structure research with radioactive ion beams at Californium Rare Ion Breeder Upgrade (CARIBU). The structure of exotic neutron-rich nuclei will be investigated at the Californium Rare Ion Breeder Upgrade (CARIBU) radioactive ion beam facility using new and novel detector systems. The results will enhance our fundamental understanding of the atomic nucleus and stellar nucleosynthesis as well as provide important data for the development of next generation nuclear reactor ....Pure and applied nuclear structure research with radioactive ion beams at Californium Rare Ion Breeder Upgrade (CARIBU). The structure of exotic neutron-rich nuclei will be investigated at the Californium Rare Ion Breeder Upgrade (CARIBU) radioactive ion beam facility using new and novel detector systems. The results will enhance our fundamental understanding of the atomic nucleus and stellar nucleosynthesis as well as provide important data for the development of next generation nuclear reactors.Read moreRead less
Investigating B Cell Development, Maintenance And High-affinity Antibody Production By ENU Mutagenesis
Funder
National Health and Medical Research Council
Funding Amount
$408,388.00
Summary
B cells are essential for the protection against infections. This application aims to identify new genes that are crucial for the development or function of B cells and will investigate how mutations in newly discovered genes contribute to defects in the development and function of B cells and the pathogenesis of B cell leukaemia.
Superdeformed nuclei and their decay: challenging nuclear models and probing quantum tunnelling. Nuclear superdeformation, where the atomic nucleus adopts an elongated, ellipsoidal shape and can undergo rapid rotation, offers a fascinating opportunity to study quantum mechanical effects in a system where single-particle and collective regimes overlap. The superdeformed shape itself is a spectacular example of collective motion in a mesoscopic system, while the rapid change to a sperhical shape ....Superdeformed nuclei and their decay: challenging nuclear models and probing quantum tunnelling. Nuclear superdeformation, where the atomic nucleus adopts an elongated, ellipsoidal shape and can undergo rapid rotation, offers a fascinating opportunity to study quantum mechanical effects in a system where single-particle and collective regimes overlap. The superdeformed shape itself is a spectacular example of collective motion in a mesoscopic system, while the rapid change to a sperhical shape is an excellent example of quantum-assisted tunnelling. The results of this project will shed light on this important process and provide a stringent test of our understanding of the nucleus.Read moreRead less
Isomers as Probes of Nuclear Structure and Sources of Energetic Photons. The aim is to study exotic long-lived states in nuclei using accelerator facilities in Australia and overseas. This involves the development of sensitive instrumentation and will lead to a new understanding of how such states are formed, of how they may be used to identify the structure of exotic nuclei, and on the limits of stability of nuclei in general. Isomers represent a special form of nuclear matter and they play a r ....Isomers as Probes of Nuclear Structure and Sources of Energetic Photons. The aim is to study exotic long-lived states in nuclei using accelerator facilities in Australia and overseas. This involves the development of sensitive instrumentation and will lead to a new understanding of how such states are formed, of how they may be used to identify the structure of exotic nuclei, and on the limits of stability of nuclei in general. Isomers represent a special form of nuclear matter and they play a role in the formation of the elements in stellar nucleosynthesis. Stimulated isomer decay may ultimately lead to new forms of energy storage and gamma-ray lasers.Read moreRead less
Moments, monopoles and the emergence of nuclear collectivity. The project aims to elucidate the origin and nature of collective nuclear vibrations. Recent evidence that vibrational nuclei might not vibrate after all has shaken the foundations of nuclear theory. This project will measure electric monopole transitions and magnetic moments to help determine these nuclei’s true nature, and expose how their collectivity emerges from the complexity of the underlying single-particle motion. The expecte ....Moments, monopoles and the emergence of nuclear collectivity. The project aims to elucidate the origin and nature of collective nuclear vibrations. Recent evidence that vibrational nuclei might not vibrate after all has shaken the foundations of nuclear theory. This project will measure electric monopole transitions and magnetic moments to help determine these nuclei’s true nature, and expose how their collectivity emerges from the complexity of the underlying single-particle motion. The expected outcome is a deeper understanding of emergent phenomena in quantum many-body systems like the atomic nucleus.Read moreRead less
Quantum-number purity and limits to the formation of nuclear K-isomers. This internationally competitive research will result in new knowledge and the substantiation of Australian research in the nuclear structure area, as well as adding to our role in international scientific collaborations. The research is an important component of the local expertise in nuclear science established using Australian facilities which provide the major training ground for basic research, a variety of application ....Quantum-number purity and limits to the formation of nuclear K-isomers. This internationally competitive research will result in new knowledge and the substantiation of Australian research in the nuclear structure area, as well as adding to our role in international scientific collaborations. The research is an important component of the local expertise in nuclear science established using Australian facilities which provide the major training ground for basic research, a variety of applications and which also provide a source of strategically important expertise.
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Genotypes And Phenotypes Of Human Primary Non-congenital Antibody Deficiency
Funder
National Health and Medical Research Council
Funding Amount
$544,692.00
Summary
Antibodies represent a key component of the immune system, and a particularly important in defence against bacterial and viral infections. In some individuals, antibody production fails, rendering them more susceptible to infection. In most cases, the mechanism of antibody failure is unknown. This project seeks to determine the genetic and cellular mechanisms of antibody failure. This could improve diagnosis for immune deficiency, and improve our overall understanding of the immune system.
Understanding The Role Of The Putative Phospholipid Translocase ATP11c In B Cell Development
Funder
National Health and Medical Research Council
Funding Amount
$455,153.00
Summary
The immune system protects humans against recurrent infections with a wide range of pathogens. Formation of antibodies is a crucial element of the immune response. Defects in the production of antibodies can lead to recurrent and often life-threatening infections. This project seeks to understand a genetic defect in mice resulting in an almost complete absence of antibody producing cells, thereby causing a disease that is similar to some forms of human immunodeficiency.
Structure of Hadronic Excitations from Lattice Quantum Chromodynamics. Quantum chromodynamics describes the fundamental strong interactions between quarks and gluons as they compose hadrons such as the proton or neutron. Beyond these lowest-energy systems, the quantum mechanical excitation spectra display a rich and complex structure. Remarkably, little is known about the internal structure of these states. The central goal of this project is to unveil the nature of hadrons and their excited sta ....Structure of Hadronic Excitations from Lattice Quantum Chromodynamics. Quantum chromodynamics describes the fundamental strong interactions between quarks and gluons as they compose hadrons such as the proton or neutron. Beyond these lowest-energy systems, the quantum mechanical excitation spectra display a rich and complex structure. Remarkably, little is known about the internal structure of these states. The central goal of this project is to unveil the nature of hadrons and their excited states using the first principles approach of lattice gauge theory. By elucidating aspects of hadron structure in terms of the most fundamental non-perturbative quark and gluon fields, the project will create new knowledge impacting on renowned experimental programs at international facilities.Read moreRead less