Mineralocorticoid Receptors - Mechanisms Of Ligand- And Tissue- Specific Activation
Funder
National Health and Medical Research Council
Funding Amount
$126,848.00
Summary
Heart disease is a major cause of death and economic burden in Australia and throughout the world. The steroid hormone aldosterone controls salt and water balance, blood pressure and has a significant role in heart failure. Although drugs that block the aldosterone receptor significantly help patients with heart failure, their use is limited by side effects. This work will identify the profile of proteins that promote aldosterone effects and enable the development of heart-specific blockers.
Mineralocorticoid Receptor Co-regulator Recruitment Determines Ligand Specific Signalling.
Funder
National Health and Medical Research Council
Funding Amount
$491,530.00
Summary
Heart disease is a major cause of death and economic burden in Australia and throughout the world. The steroid hormone aldosterone controls salt and water balance,blood pressure and hasa significant role in heart failure. Although drugs that block the aldosterone receptor significantly help patients with heart failure, their use is limited by side effects. This work will identify the profile of proteins that promote aldosterone effects and enable the development of heart-specific blockers.
Functional Role Of A Novel Coregulator In Metabolism
Funder
National Health and Medical Research Council
Funding Amount
$563,146.00
Summary
Australia is facing a massive epidemic of diabetes and obesity (diabesity). These disorders afflict all age groups, including teenagers, and are a major burden to the health and wealth of Australia. The nuclear receptors and their coregulators are excellent targets for developing new therapeutics to combat these disorders. This grant will evaluate the functional role of SLIRP, a novel nuclear receptor coregulator, in metabolism and could provide new avenues for drug target development.