The Role And Inheritance Of Constitutional Epimutations In Early-onset Colorectal Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$347,551.00
Summary
Traditionally familial cancers are thought to be caused by spelling mistakes within the genetic code of cancer prevention genes. Our group has found that chemical attachments to one gene (MLH1) stops it working, even where there is no spelling mistake, and that those chemical changes can be inherited in families with bowel cancer. We will determine how frequently this type of defect occurs in bowel cancer patients, how and why it arises, and if other cancer genes are similarly affected.
The vision we rely on every day to read and recognise faces depends upon the health of the central portion of our retina, the macula. Age-related Macular Degeneration (AMD) is the leading cause of blindness in Australia and the western world. Researchers at the Australian National University are collaborating to bring a new test for AMD severity to the market within 3 years. The objective is to provide doctors with a rapid, cost-effective tool to help them manage treatment.
Validation Of A Multiplexed Blood Based Screening Assay For The Diagnosis Of Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$556,712.00
Summary
Colorectal cancer (CRC) is the second most common cancer in Australia with poor patient outcome due to late detection of the disease. We have developed a simple blood based test that can diagnose individuals with CRC at an early stage when the chance of cure is greater than 80%.
Two-Eyed Seeing – A Framework For Cultural Fishery Assessments Supporting Equitable And Sustainable Access To Shared Resources In NSW Inland Rivers
Funder
Fisheries Research and Development Corporation
Funding Amount
$1,460,500.00
Summary
Fish are totemic and a primary food source; and so are part of the deep cultural, spiritual and economic connections Aboriginal communities have to their waterways that are part of ‘Country’. Cultural knowledge tells us that when there’s more water availability cultural fishers experience increased total catches and greater diversity of target species, and they fish more (e.g. increase in recreational and subsistence fishing). These narratives also suggest that as a result of these improved cult ....Fish are totemic and a primary food source; and so are part of the deep cultural, spiritual and economic connections Aboriginal communities have to their waterways that are part of ‘Country’. Cultural knowledge tells us that when there’s more water availability cultural fishers experience increased total catches and greater diversity of target species, and they fish more (e.g. increase in recreational and subsistence fishing). These narratives also suggest that as a result of these improved cultural fishing opportunities, there are flow on socio-economic benefits to household budgets, diets of communities, social behaviours and mental health and well-being.
Water is sacred and living; and central to the cultural, social and spiritual identity of Aboriginal people, as well as to their livelihoods. Conceptual models underpinning western water management frameworks and decision making do not incorporate Aboriginal/First Nations socio-cultural complexity, local knowledge and governance arrangements. These are critical – Aboriginal/First Nations people have strong connections with fish, water, rivers and knowledge to contribute to planning, as well as a fundamental right to participate. Water and fish are central to the way of life, two-way knowledge and planning frameworks will support reciprocity in engagement and participation.
Two-Eyed Seeing Frameworks (Ganma, Yolgnu for two-ways) provide a way forward for cultural fishery assessments supporting equitable and sustainable access to shared resources. In this framework, knowledge systems (western and cultural) contribute in parallel, on an equal footing, and both serve as evidence bases to produce an enriched picture of mutual understanding. Application of this framework can empower Aboriginal communities to participate more equitably and negotiate by using their science and values and providing a method for inclusion.
The overall objective of this proposed project is to empower Aboriginal communities through application of a “Two-Eyed seeing framework” (Reid et al. 2020) to participate more equitably and negotiate for cultural fishing practices and water allocation and management. This project will define the cultural fishery and quantify the socio-economic value of cultural fishing in two NSW river regions, and assist communities to identify water management needs for key cultural fish species to support ongoing planning and negotiations. It will improve our current fishery and water management by providing a pathway for cultural fisheries and cultural science to be included. Overall, it will increase our current knowledge of fish and fisheries, by bridging the gap between cultural science and western science practitioners and knowledge holders to share understandings, insights and skills. The application and extension of this framework to a national project will be considered for future use in addressing cultural fishery allocations and management.
Objectives: 1. Identify suitable NSW riverine cultural fisheries, engage with Aboriginal Communities, Traditional Owners, codesign the project and confirm move to phase 2. 2. Define and quanitfy the cultural fishery and associated totemic, cultura and social values 3. Identify and describe fish objectives and water management needs for cultural fish species using the Fish and Flows Framework. 4. Determine if changes in (2) are related to changes in water availability, policy and operations and/or river restoration activities (e.g. fish passage restoration, cold water passage, screening), if possible. 5. Objectively assess the efficacy and utility of the “Two-Eyed Seeing framework” in assessing the totemic, culutal and social fishing values and linking them to the fish and flows framework, including consideration of National applicability. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989986
Funder
Australian Research Council
Funding Amount
$230,000.00
Summary
Hybrid Fourier Transform Dispersive Raman Micro-Spectrometer. This facility will be used in a wide range of existing and new research projects in government priority areas such as the development of new materials, frontier technologies for building and transforming existing industries, better understanding of diversity and functioning in mycorrhizal and other fungi in forest soils and plant roots and developing new characterisation methods for forensic investigations. The proposed equipment aims ....Hybrid Fourier Transform Dispersive Raman Micro-Spectrometer. This facility will be used in a wide range of existing and new research projects in government priority areas such as the development of new materials, frontier technologies for building and transforming existing industries, better understanding of diversity and functioning in mycorrhizal and other fungi in forest soils and plant roots and developing new characterisation methods for forensic investigations. The proposed equipment aims to provide outstanding opportunities for the training of research students, expanding research in the fields of materials, minerals, geological, environmental and forensic science enabling to maintain Australia's lead and competitiveness in cutting edge research and technology. Read moreRead less
SCRC: PhD : An Investigation Of The Microbiology And Biotechnical Properties Leading To Extended Shelf-life In Goldband Snapper (Pristipomoides Multidens)
Funder
Fisheries Research and Development Corporation
Summary
Tropical snapper species are have a highly variable shelf-life during chilled storage. The overall aim of this project is to determine why Goldband Snapper (Pristipomoides multidens) has a greater shelf life than some similar fish species and to use this knowledge to produce some practical applications to increase shelf-life in other species with shorter shelf-life. To do this we will investigate the microbiological and biochemical properties of Goldband Snapper and, using a control species for ....Tropical snapper species are have a highly variable shelf-life during chilled storage. The overall aim of this project is to determine why Goldband Snapper (Pristipomoides multidens) has a greater shelf life than some similar fish species and to use this knowledge to produce some practical applications to increase shelf-life in other species with shorter shelf-life. To do this we will investigate the microbiological and biochemical properties of Goldband Snapper and, using a control species for comparison, determine if any of these properties are responsible for the long shelf life observed with this fish species. The control species for this project, the Saddleback Snapper (Paracaesio kusakarii), was chosen because it is a similar fish but with a much shorter shelf life. If any significant differences are detected, the possibility of transferring or replicating these properties onto other fish will be investigated. This project will impact greatly on the fishing industry if particular bacteria (or lack of bacteria) or other properties which promote long shelf life are able to be identified and replicated on other fish species.
The project is related to and arose as a result of FRDC 2006/209 “Developing targeted strategies for improving product quality through selected low value seafood supply chains.” and will continue working with currently estabished industry partners including WAFIC and WA Department of Fisheries. The project will be under the auspices of the WA Centre of Excellence for Seafood (CoES), and is particularly associated with the supply chain performance theme of the CoES.Read moreRead less
Uncovering The Basis Of Inflammatory And Immunodeficiency Diseases
Funder
National Health and Medical Research Council
Funding Amount
$15,718,075.00
Summary
A world-class team from 3 institutions, spanning disciplines of clinical and experimental immunology, therapeutics, signalling and genetics, will identify how immune and inflammatory responses are controlled in both health and disease. The major outcomes of this work will be the generation of new knowledge, concepts and approaches to diagnose, prevent and treat the major human health problems of autoimmune diseases, inflammation, allergy and immunodeficiency.
Asymmetric Synthesis of Chiral Phosphines, Arsines, and Stibines. There are now chiral phosphine-transition metal catalysts that rival enzymes in their efficiency for the asymmetric synthesis of important chiral drugs, fragrants, cosmetics, nutrients, vitamins, and pesticides. This project is aimed at a generalised asymmetric synthesis of the critical components of these enzyme mimics, notably enantiopure chiral phosphines, but also chiral arsines and stibines, by a highly innovative approach t ....Asymmetric Synthesis of Chiral Phosphines, Arsines, and Stibines. There are now chiral phosphine-transition metal catalysts that rival enzymes in their efficiency for the asymmetric synthesis of important chiral drugs, fragrants, cosmetics, nutrients, vitamins, and pesticides. This project is aimed at a generalised asymmetric synthesis of the critical components of these enzyme mimics, notably enantiopure chiral phosphines, but also chiral arsines and stibines, by a highly innovative approach that involves novel six-electron phosphenium, arsenium, and stibinium cations that are themselves stabilised by chiral phosphines so that chemical breeder reactions are possible. The use of chiral auxiliaries from the natural pool and from biotechnology will also be investigated.Read moreRead less