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Chronic inflammation underlies common and debilitating diseases and causes pain by unknown mechanisms. There is an urgent need to gain a deeper understanding of the mechanisms of chronic pain, which will allow the development of improved therapies with fewer side-effects. Our research program investigates the mechanisms of pain that are associated with inflammatory bowel disease and irritable bowel syndrome, with the goal of developing more effective and selective therapies.
GABA(B) Receptor Modulation Of Gastrointestinal Function In Health And Disease By Alpha-Conotoxins
Funder
National Health and Medical Research Council
Funding Amount
$689,050.00
Summary
Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.
Targeting RCAN1 To Treat Type 2 Diabetes And Obesity
Funder
National Health and Medical Research Council
Funding Amount
$814,468.00
Summary
Obesity and impaired insulin secretion are significant contributors to Type 2 diabetes. In this project we demonstrate that a protein called RCAN1 contributes to both fat mass and insulin secretion and that this contribution is exacerbated in obesity and in Type 2 diabetes. We will identify how RCAN1 controls these major metabolic pathways with outcomes including the development of new therapeutics for obesity and Type 2 diabetes.
Transport of metals in vapours and brines: new insights into the formation of the Earth's mineral deposits. Traditional models for the formation of hydrothermal ore deposits assume that aqueous fluids transported the metals. This view is challenged by new observations showing that gold and copper are preferentially enriched in vapours coexisting with salty aqueous fluids in some deposits. This project uses state-of-the-art techniques and develops new instruments to measure experimentally the par ....Transport of metals in vapours and brines: new insights into the formation of the Earth's mineral deposits. Traditional models for the formation of hydrothermal ore deposits assume that aqueous fluids transported the metals. This view is challenged by new observations showing that gold and copper are preferentially enriched in vapours coexisting with salty aqueous fluids in some deposits. This project uses state-of-the-art techniques and develops new instruments to measure experimentally the partitioning of metals between solid, fluid and vapour at temperatures typical for natural ore deposits (350-550C, pressures varying for vapour saturated to 1 kb). By improving our understanding of metal transport within the Earth's crust, these data will lead to improved models and technologies for exploring and processing base and precious metals.Read moreRead less
Synchrotron X-ray Assessment Of Airway Surface Physiology For Cystic Fibrosis
Funder
National Health and Medical Research Council
Funding Amount
$778,228.00
Summary
We seek a cure or long-lasting therapy for the fatal airway disease in cystic fibrosis. Disease is caused by a shallow and dehydrated airway surface liquid (ASL), allowing bacteria to infect the lung. We can introduce a corrective gene into mouse airways where it can be effective for over 1 yr, but no fast, accurate and non-invasive measurement exists to test if treatments are successful. We will develop methods using synchrotron light to directly measure ASL depth changes in live mouse airways.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100001
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
An advanced thermogravimetric analysis system for world-leading research in clean energy, catalysis, material science and nanotechnology. Many chemical reactions occurring in solid materials during heating significantly affect the materials' stability, and subsequently affects the processes of production of clean energy, material synthesis, catalyst preparation, and nanotechnology. No equipment currently exists in Australia that will mitigate the wide range of conditions in such reactions in ma ....An advanced thermogravimetric analysis system for world-leading research in clean energy, catalysis, material science and nanotechnology. Many chemical reactions occurring in solid materials during heating significantly affect the materials' stability, and subsequently affects the processes of production of clean energy, material synthesis, catalyst preparation, and nanotechnology. No equipment currently exists in Australia that will mitigate the wide range of conditions in such reactions in materials processing. This situation impedes research progress in Australia, disadvantages Australian research students, and ultimately makes our research less competitive internationally. The establishment of the proposed apparatus will increase the competitiveness of Australian science and engineering, and contribute to the development of new Australian technologies that are important to the Australian economy and to environmental sustainability.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882493
Funder
Australian Research Council
Funding Amount
$700,000.00
Summary
High-accuracy spectroscopy under extreme conditions: combining novel synchrotron and laboratory-based spectroscopy. This project aims at maintaining the leading position of Australia in nationally important fields such as ore and environmental geology, ore processing and metallurgy, nano- and bio-technology. This project aims to establish an integrated set of state-of-the-art, often unique and revolutionary new tools, taking in particular advantage of local innovation in instrumentation and spec ....High-accuracy spectroscopy under extreme conditions: combining novel synchrotron and laboratory-based spectroscopy. This project aims at maintaining the leading position of Australia in nationally important fields such as ore and environmental geology, ore processing and metallurgy, nano- and bio-technology. This project aims to establish an integrated set of state-of-the-art, often unique and revolutionary new tools, taking in particular advantage of local innovation in instrumentation and spectroscopy theory, of the investment in major facilities (Australian Synchrotron). By improving cross-disciplinary links among research groups interested in in-situ spectroscopy (Earth Sciences, Physics, Chemistry, Biological Sciences, Biochemistry, Biomedicine, Engineering), this application will results in major scientific and industrial advances.Read moreRead less