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Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
Spinal Cord Injury Pain: Understanding Mechanisms To Develop Treatments
Funder
National Health and Medical Research Council
Funding Amount
$597,675.00
Summary
Spinal cord injury has devastating effects on health and quality of life. Many of the major consequences of injury, such as chronic pain and loss of voluntary voiding, are "invisible" – i.e., they are not as visible as limitations of mobility. Our study aims to define the neurobiological changes that cause development of persistent pain after spinal cord injury and use pharmacological tools to attenuate the development of pain.
Optimising Heart Disease Prevention And Management
Funder
National Health and Medical Research Council
Funding Amount
$4,647,175.00
Summary
As we become older and risk factors such as obesity become more common, our biggest contributor to death and disability, cardiovascular disease (including heart disease), will continue to exert an enormous burden on our health care system and society. We will extend our ground-breaking research on multidisciplinary teams to create new and innovative health care programs to optimise the prevention and management of new heart disease and chronic forms of heart disease.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989986
Funder
Australian Research Council
Funding Amount
$230,000.00
Summary
Hybrid Fourier Transform Dispersive Raman Micro-Spectrometer. This facility will be used in a wide range of existing and new research projects in government priority areas such as the development of new materials, frontier technologies for building and transforming existing industries, better understanding of diversity and functioning in mycorrhizal and other fungi in forest soils and plant roots and developing new characterisation methods for forensic investigations. The proposed equipment aims ....Hybrid Fourier Transform Dispersive Raman Micro-Spectrometer. This facility will be used in a wide range of existing and new research projects in government priority areas such as the development of new materials, frontier technologies for building and transforming existing industries, better understanding of diversity and functioning in mycorrhizal and other fungi in forest soils and plant roots and developing new characterisation methods for forensic investigations. The proposed equipment aims to provide outstanding opportunities for the training of research students, expanding research in the fields of materials, minerals, geological, environmental and forensic science enabling to maintain Australia's lead and competitiveness in cutting edge research and technology. Read moreRead less
GABA(B) Receptor Modulation Of Gastrointestinal Function In Health And Disease By Alpha-Conotoxins
Funder
National Health and Medical Research Council
Funding Amount
$689,050.00
Summary
Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.
Cementitious gel: the missing link in understanding the ageing of built infrastructure. Exposure of built reinforced concrete infrastructure to coastal environments causes premature ageing, unplanned remediation and reduced safety. Enhanced forecasting, achieved by advanced methods, including Helium Ion Microscopy and modeling interactions between cement gel, chloride and water, will deliver proactive management of ageing assets.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100115
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
High-temperature probes for investigating phase transitions and reaction kinetics in thin films, nanostructured materials and biomaterials. This infrastructure for high temperature surface analysis and in-situ diagnostics as a function of temperature and gas environments will enhance Australia's capabilities in creating new materials for devices that will meet needs in medical, communications, environmental and security applications. The facility will enable researchers to understand and exploi ....High-temperature probes for investigating phase transitions and reaction kinetics in thin films, nanostructured materials and biomaterials. This infrastructure for high temperature surface analysis and in-situ diagnostics as a function of temperature and gas environments will enhance Australia's capabilities in creating new materials for devices that will meet needs in medical, communications, environmental and security applications. The facility will enable researchers to understand and exploit interfacial phenomena and to tailor processing-microstructure-composition correlations, so as to design new materials with the best performance possible. Probes with unique capabilities will measure surface morphology, optical properties, elemental composition and crystallographic phase.The facility will be the first in Australia to offer a comprehensive study of structure and properties at high temperature.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775533
Funder
Australian Research Council
Funding Amount
$700,000.00
Summary
A New Generation Noble Gas Mass Spectrometer Facility for Advanced Research in the Earth, Planetary and Environmental Sciences. The current proposal, to establish a new Noble Gas Analytical Consortium for noble gas chronological and geochemical analyses, will generate new knowledge on the evolution of the Earth, with profound implications for past climate change, landscape evolution, formation of ore bodies, and terrestrial geodynamics. Consequently, the facility will conform to the National Res ....A New Generation Noble Gas Mass Spectrometer Facility for Advanced Research in the Earth, Planetary and Environmental Sciences. The current proposal, to establish a new Noble Gas Analytical Consortium for noble gas chronological and geochemical analyses, will generate new knowledge on the evolution of the Earth, with profound implications for past climate change, landscape evolution, formation of ore bodies, and terrestrial geodynamics. Consequently, the facility will conform to the National Research Priority of 'An Environmentally Sustainable Australia'. The new facility will ensure that Australian research remains at the forefront of international science development and will also provide essential training for the next generation of Australian scientists.Read moreRead less
X-ray tomographic analysis and modelling of metallurgical coke. This project will apply 3D X-ray micro-tomography and model-based computational analysis to develop innovative approaches to the micro-structural characterisation of metallurgical coke. This has significant ramifications for the iron industry since coke characterisation is of primary importance to improved blast furnace productivity. The project will deliver new quantitative indices of coke microstructure, develop models for simulat ....X-ray tomographic analysis and modelling of metallurgical coke. This project will apply 3D X-ray micro-tomography and model-based computational analysis to develop innovative approaches to the micro-structural characterisation of metallurgical coke. This has significant ramifications for the iron industry since coke characterisation is of primary importance to improved blast furnace productivity. The project will deliver new quantitative indices of coke microstructure, develop models for simulation of micro-structural properties and coke transport properties, and examine coke reactivity in 3D contexts. This project will also be the first study to use multi-scale 3D X-ray tomographic analysis to examine the structural dynamics of coke during both its production and its use in the blast furnace.Read moreRead less
Understanding and reversing the habitat shifts that have endangered the broad-headed snake. Extinction rates for vertebrate species are higher in southern Australia than almost anywhere else in the world, and saving endangered taxa is critical to biodiversity conservation. To do this effectively, researchers need to understand the processes that threaten wild populations, and to develop novel solutions to those problems in close collaboration with wildlife management authorities and other stake ....Understanding and reversing the habitat shifts that have endangered the broad-headed snake. Extinction rates for vertebrate species are higher in southern Australia than almost anywhere else in the world, and saving endangered taxa is critical to biodiversity conservation. To do this effectively, researchers need to understand the processes that threaten wild populations, and to develop novel solutions to those problems in close collaboration with wildlife management authorities and other stakeholders. This project will build such an understanding and collaboration, focusing on an endangered snake species. We propose ambitious landscape-scale field experiments that will simultaneously test hypotheses on threatening processes, and restore habitat quality to reverse population declines.Read moreRead less