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Improving Pain And Movement Outcomes In Symptomatic Knee Osteoarthritis
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
People fear getting painful knee osteoarthritis (OA) more than any other disease – it is seen as progressive and incurable. It often stops people from moving and staying healthy, resulting in an enormous burden on sufferers and the health care system. This program of research aims to understand what brain & nervous system processes might underlie these pain and movement problems and whether new brain-targeting treatment helps. This will allow us to better match treatment to what patients need.
GABA(B) Receptor Modulation Of Gastrointestinal Function In Health And Disease By Alpha-Conotoxins
Funder
National Health and Medical Research Council
Funding Amount
$689,050.00
Summary
Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668155
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
Instrumentation for combined seismic and electromagnetic Earth sounding. The set of geophysical recorders will provide the means to enhance understanding of the structure of the Australian continent in 3-D. The interpretation of multiple images of Earth structure will help to link features in the crust and mantle beneath, and provide controls on the evolution and assembly of the present continent, with a major contribution to possible geotransects as recommended in the 2003 National Strategic Pl ....Instrumentation for combined seismic and electromagnetic Earth sounding. The set of geophysical recorders will provide the means to enhance understanding of the structure of the Australian continent in 3-D. The interpretation of multiple images of Earth structure will help to link features in the crust and mantle beneath, and provide controls on the evolution and assembly of the present continent, with a major contribution to possible geotransects as recommended in the 2003 National Strategic Plan for the Geosciences. Combining seismic and electromagnetic methods will provide both geochemeical and geophysical constaints, e.g., on zones of alteration and shear with the potential for deep mineralisation. Read moreRead less
Dispersal and gene flow in habitat-forming algae. The temperate coast of Australia has a unique and diverse algal flora. Many of these algae play a central role in subtidal ecology by providing habitat to an astonishing diversity of taxa. Despite this, we have no understanding of levels of gene flow within and among populations of habitat forming algae or how such populations persist in nature. By addressing this lack of knowledge, my research will contribute information that is critical for the ....Dispersal and gene flow in habitat-forming algae. The temperate coast of Australia has a unique and diverse algal flora. Many of these algae play a central role in subtidal ecology by providing habitat to an astonishing diversity of taxa. Despite this, we have no understanding of levels of gene flow within and among populations of habitat forming algae or how such populations persist in nature. By addressing this lack of knowledge, my research will contribute information that is critical for the conservation and management of algal habitats. This is particularly pertinent because anthropogentic stressors are beginning to precipitate significant changes in algal forests along Australia's coastline. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100009
Funder
Australian Research Council
Funding Amount
$1,064,000.00
Summary
Ultra-high resolution magnetic resonance imaging (MRI) system for physical applications. Ultra-high resolution magnetic resonance imaging (MRI) system for physical applications: Ultra-high field magnetic resonance imaging provides unique high contrast images at previously inaccessible levels of resolution (<0.1mm). It non-invasively provides unprecedented information on chemical and biochemical processes including functional biological mechanisms. This infrastructure will be the focal point for ....Ultra-high resolution magnetic resonance imaging (MRI) system for physical applications. Ultra-high resolution magnetic resonance imaging (MRI) system for physical applications: Ultra-high field magnetic resonance imaging provides unique high contrast images at previously inaccessible levels of resolution (<0.1mm). It non-invasively provides unprecedented information on chemical and biochemical processes including functional biological mechanisms. This infrastructure will be the focal point for more than 100 academics and HDR students. It will take Australia to the forefront of magnetic resonance imaging capability as well as providing unique insights into diffusion and electrophoretic problems central to designing next generation energy storage. Outcomes will range from agricultural advances, higher performing batteries, and more effective cancer treatments as well advancing Australia's fundamental scientific capabilities.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100155
Funder
Australian Research Council
Funding Amount
$495,000.00
Summary
High-Speed Particle Image Velocimetry and Laser-Induced Fluorescence Facility. This state-of-the-art laser facility will increase our scientific understanding of industrial processes by providing valuable information on velocity, temperature and concentration profiles for rapidly changing flow fields. Previously it was not possible to do this, and the knowledge gained will be applied to develop more efficient and environmentally sustainable operations. For example, many current processes have hi ....High-Speed Particle Image Velocimetry and Laser-Induced Fluorescence Facility. This state-of-the-art laser facility will increase our scientific understanding of industrial processes by providing valuable information on velocity, temperature and concentration profiles for rapidly changing flow fields. Previously it was not possible to do this, and the knowledge gained will be applied to develop more efficient and environmentally sustainable operations. For example, many current processes have high energy input but scientific evidence suggests that it can be reduced if the embodied energy of the flow is properly utilised. Importantly, this utilisation often leads to increased yields and product quality. The facility will greatly assist researchers and industry collaborators in developing processes for the 21st century.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100001
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
An advanced thermogravimetric analysis system for world-leading research in clean energy, catalysis, material science and nanotechnology. Many chemical reactions occurring in solid materials during heating significantly affect the materials' stability, and subsequently affects the processes of production of clean energy, material synthesis, catalyst preparation, and nanotechnology. No equipment currently exists in Australia that will mitigate the wide range of conditions in such reactions in ma ....An advanced thermogravimetric analysis system for world-leading research in clean energy, catalysis, material science and nanotechnology. Many chemical reactions occurring in solid materials during heating significantly affect the materials' stability, and subsequently affects the processes of production of clean energy, material synthesis, catalyst preparation, and nanotechnology. No equipment currently exists in Australia that will mitigate the wide range of conditions in such reactions in materials processing. This situation impedes research progress in Australia, disadvantages Australian research students, and ultimately makes our research less competitive internationally. The establishment of the proposed apparatus will increase the competitiveness of Australian science and engineering, and contribute to the development of new Australian technologies that are important to the Australian economy and to environmental sustainability.Read moreRead less
Investigation of the coupled dependence of concentrated solar radiation and combustion in a novel solar hybrid technology. The project will develop the models necessary for the optimisation of a novel solar-combustion hybrid technology and a novel heat exchanger component. It will deliver a solar thermal technology that lowers the cost of solar energy with immediate potential in off-grid sites, such as in remote mines, in Australia and throughout the world.
Commercial scale production of biocrude by hydrothermal liquefaction. The project aims to develop new understanding and tools to support commercial-scale production of biocrude from microalgae or biosolids and enable a breakthrough in cost-effective production of sustainable fuels. A novel hydrothermal liquefaction reactor has been developed that has strong potential to overcome the limitations of Muradel's existing demonstration reactor which, while world-leading, is uneconomical at commercial ....Commercial scale production of biocrude by hydrothermal liquefaction. The project aims to develop new understanding and tools to support commercial-scale production of biocrude from microalgae or biosolids and enable a breakthrough in cost-effective production of sustainable fuels. A novel hydrothermal liquefaction reactor has been developed that has strong potential to overcome the limitations of Muradel's existing demonstration reactor which, while world-leading, is uneconomical at commercial scale. The project aims to develop design tools to optimise the new reactor, comprising a chemical model of the complex, multi-component hydrothermal liquefaction reactions, a computational model of the mixing and heat transfer within it and a network model of the energy and exergy flows.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100220
Funder
Australian Research Council
Funding Amount
$760,000.00
Summary
Adaptive Electrical Capacitance Volume Tomography for Multiphase Flows. This project aims to establish a cutting edge adaptive electrical capacitance volume tomography facility for real-time metering / imaging of multi-phase flows. Optimisation of these flows which are encountered in many industries, is paramount in today's carbon-constrained global economy. This project expects to generate the new knowledge necessary for such optimisations. Expected outcomes include enhanced national capability ....Adaptive Electrical Capacitance Volume Tomography for Multiphase Flows. This project aims to establish a cutting edge adaptive electrical capacitance volume tomography facility for real-time metering / imaging of multi-phase flows. Optimisation of these flows which are encountered in many industries, is paramount in today's carbon-constrained global economy. This project expects to generate the new knowledge necessary for such optimisations. Expected outcomes include enhanced national capability for characterisation of multi-phase flows in real-time under both ambient and high temperatures. This should benefit and greatly facilitate the commercial rollout of novel technologies in industrial sectors as diverse as mineral processing, clean energy, fuels/chemicals, oil/gas, food and environmental remediation. Read moreRead less