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Atrial Fibrillation And Hypertension: Reverse Cardiac Remodelling Post Renal Denervation
Funder
National Health and Medical Research Council
Funding Amount
$90,144.00
Summary
Patients with hypertension are at increased risk of heart rhythm disorders, yet little is known if treatment of high blood pressure will improve abnormal rhythm. Renal denervation is a new and effective treatment for severe hypertension; this study will assess the adverse changes in heart structure and function due to severe hypertension, and investigate whether renal denervation can ameliorate these changes on a structural and electrical level.
Genetic Predisposition To Abnormal Atrial Substrate In Atrial Fibrillation (GENE-AF Study)
Funder
National Health and Medical Research Council
Funding Amount
$100,531.00
Summary
Atrial fibrillation (AF) is the most common heart rhythm disorder worldwide and its incidence is growing. Our world-first research aims to demonstrate that individuals who carry specific genetic variants are more likely to develop abnormal electrical and structural changes in the heart, which predispose to AF. In doing so, we intend to find the link between genetics and AF, paving the way for research into novel targeted therapies to better manage this complex and difficult to treat disease.
The Communication Of Acute Postoperative Pain (CAPP):the Clinically Significant Meanings Behind Numerical Pain Ratings
Funder
National Health and Medical Research Council
Funding Amount
$93,742.00
Summary
Between 45% – 80% of patients still have moderate to severe pain after surgery and receive less than 50% of the pain medications available. Using a 0 – 10 pain rating can contribute to this problem because there is no consistent understanding about what the numbers mean or how they should guide pain management decisions. The project aim is to develop a standard approach to using a numerical pain rating to assist patients to report the severity of their pain in ways that assists clinicians to dec ....Between 45% – 80% of patients still have moderate to severe pain after surgery and receive less than 50% of the pain medications available. Using a 0 – 10 pain rating can contribute to this problem because there is no consistent understanding about what the numbers mean or how they should guide pain management decisions. The project aim is to develop a standard approach to using a numerical pain rating to assist patients to report the severity of their pain in ways that assists clinicians to decide the best pain management.Read moreRead less
Low back pain is a major global health problem and the leading cause of disability worldwide . This project will trial a new treatment for back pain that is specifically aimed at risk factors for developing ongoing back problems. Previously shown to be successful in patients suffering persistent back problems, this promising new treatment will be trialled in patients soon after they develop lower back pain as a preventative approach.
Prediction Of Ventricular Arrhythmias And Prevention Of Sudden Cardiac Death Following Revascularised Acute Myocardial Infarction.
Funder
National Health and Medical Research Council
Funding Amount
$117,270.00
Summary
Acute myocardial infarction (AMI) is a leading cause of death in Australia. Patients with coronary artery disease and impaired left ventricular function are at increased risk of heart failure, reinfarction and sudden cardiac death (SCD). This research will evaluate optimal methods to identify patients at risk for SCD following AMI using echocardiographic, MRI, and electrophysiological characteristics, and improve survival by early identification and management of these high-risk patients.
The Effect Of Exercise Training On Cardiac Structure, Function And The Electrocardiogram In Indigenous And Non-Indigenous Elite Australian Athletes.
Funder
National Health and Medical Research Council
Funding Amount
$133,351.00
Summary
The sudden death of an athlete is a tragic event with substantial emotional and social impact on the community.Evidence suggests that cardiac screening of competitive athletes can significantly reduce this risk (reduction of sudden cardiac death in Italy by 75%).It is imperative that we obtain data on both indigenous and non-indigenous athletes in the Australian setting to develop a normal range for our population if we are to develop an effective screening programme.
Exploring The Link Between Alcohol And Atrial Fibrillation Recurrence: A Multicentre Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$122,714.00
Summary
Atrial fibrillation (AF) is the most common cardiac rhythm disturbance & is associated with a doubling in mortality (due to heart failure & stroke) and significant morbidity. Recent studies indicate that alcohol intake (even at mild-moderate levels) is a risk factor for AF. This world-first multicentre randomised controlled trial of 200 patients with AF aims to determine whether abstinence from alcohol (or significantly reduced consumption) will reduce frequency and burden of AF episodes.
Why Do People Develop Chronic Low Back Pain? An Investigation Of Brain Function As A Predictor Of Chronic Low Back Pain.
Funder
National Health and Medical Research Council
Funding Amount
$96,631.00
Summary
Chronic low back pain is the most disabling condition worldwide. Two objective measures of brain function, electrical signals of brain activity (electroencephalography), and attentional bias observed with eye tracking technology will be measured in a group of participants with acute back pain. These measurements will provide objective markers of brain function that may be predictive of the transition from acute to chronic low back pain, providing new opportunities for treatment.
An Exploration Of The Mechanisms Underlying A Novel Pain Biology Education Intervention (Explain Pain) In Reducing The Development Of Chronic Low Back Pain
Funder
National Health and Medical Research Council
Funding Amount
$106,057.00
Summary
Chronic low back pain is a massive health problem in Australia. This research will investigate the underlying mechanisms of modulating one’s thoughts and beliefs about their pain via a psychoeducative intervention after an acute episode of low back pain. Exploring the mechanisms of this intervention is a crucial step towards understanding how explaining pain could reduce the development of chronic low back pain from an acute episode of low back pain.
Surgical Management Of The Pulmonary Circulation In Children
Funder
National Health and Medical Research Council
Funding Amount
$114,328.00
Summary
Congenital disorders of the lung circulation are rare. These children often present during infancy with symptoms of heart failure and require surgery to correct these defects. Without surgery, the prognosis of these conditions are poor. Our understanding of these conditions are limited. The proposed study aims to review all patients who underwent surgical repair of abnormalities of lung arteries and veins at the Royal Children’s Hospital.